Overall performance measurement in a supply chain: towards a supplier-prime manufacturer based model

This study deals with the supply chain (SC) overall performance expression. The developed idea concerns more particularly the performance of the manufactured products. Indeed, two companies or more contribute to the manufacturing of products that are generally assembled by the prime manufacturer company. Moreover, in the industrial practice, performance scorecards are defined with regard to each process; and the overall performance is neither expressed for each company, nor for the whole SC. We propose here to identify the SC overall performance to the combination of the performances of the different involved companies in the SC. Thus, in order to obtain a definition of such performance, we choose to focus first on the performance of the prime manufacturer. In this sense, the approach is based on the SCOR model for the handling of the main processes around the considered product manufacturing. The prime manufacturer performance is then defined as the aggregation of its involved processes?? performances. While the prime manufacturer performance is strongly dependent on the suppliers?? performance, we suggest the integration of the impacting supplier performance into the prime manufacturer scorecards. From an operational point of view, the MACBETH methodology is used to coherently express both processes and overall performances. More precisely, the Choquet aggregation integral operator is applied in order to model mutual interactions between processes. Finally, the expression of a bearing??s manufacturer performance illustrates the proposition.     

A Brief Description of Gell-Mann's Lecture and How Intervals May Help to Describe Complexity in the Real World

Reliable Computing -     

Unraveling Membrane Perturbations Caused by the Bacterial Riboregulator Hfq

Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNAs. Previously, we showed that the Hfq C-terminal region forms an amyloid-like structure and that these fibrils interact with membranes. The immediate consequence of this interaction is a disruption of the membrane, but the effect on Hfq structure was unknown. To investigate details of the mechanism of interaction, the present work uses different in vitro biophysical approaches. We show that the Hfq C-terminal region influences membrane integrity and, conversely, that the membrane specifically affects the amyloid assembly. The reported effect of this bacterial master regulator on membrane integrity is discussed in light of the possible consequence on small regulatory RNA-based regulation.     

Characterization of a Cutibacterium acnes Camp Factor 1-Related Peptide as a New TLR-2 Modulator in In Vitro and Ex Vivo Models of Inflammation

Cutibacterium acnes (C. acnes) has been implicated in inflammatory acne where highly mutated Christie–Atkins–Munch–Petersen factor (CAMP)1 displays strong toll like receptor (TLR)-2 binding activity. Using specific antibodies, we showed that CAMP1 production was independent of C. acnes phylotype and involved in the induction of inflammation. We confirmed that TLR-2 bound both mutated and non-mutated recombinant CAMP1, and peptide array analysis showed that seven peptides (A14, A15, B1, B2, B3, C1 and C3) were involved in TLR-2 binding, located on the same side of the three-dimensional structure of CAMP1. Both mutated and non-mutated recombinant CAMP1 proteins induced the production of C-X-C motif chemokine ligand interleukin (CXCL)8/(IL)-8 in vitro in keratinocytes and that of granulocyte macrophage-colony stimulating factor (GM-CSF), tumor necrosis factor (TNF)-α, IL-1β and IL-10 in ex vivo human skin explants. Only A14, B1 and B2 inhibited the production of CXCL8/IL-8 by keratinocytes and that of (GM-CSF), TNF-α, IL-1β and IL-10 in human skin explants stimulated with rCAMP1 and C. acnes. Following pretreatment with B2, RNA sequencing on skin explants identified the 10 genes displaying the strongest differential expression as IL6, TNF, CXCL1, CXCL2, CXCL3, CXCL8, IL-1β, chemokine ligand (CCL)2, CCL4 and colony stimulating factor (CSF)2. We, thus, identified a new CAMP1-derived peptide as a TLR-2 modulator likely to be a good candidate for clinical evaluation.     

GD&T-Based Characterization of Short-Range Non-contact 3D Imaging Systems

We present a series of test metrics, artifacts, and procedures for characterizing and verifying the operating limits of a short-range non-contact three-dimensional imaging system. These metrics have been designed to correspond to dimensioning and tolerancing metrics that are widely used in industry (e.g. automotive, aerospace, etc.). We introduce operating limit metrics that correspond with the geometric dimensioning and tolerancing (GD&T) metrics of Form (Flatness and Circularity), Orientation (Angularity), Location (Sphere, Corner, and Hole Position Errors), and Size (Diameter, Sphere-spacing, Plane-spacing and Angle Errors). An example is presented to illustrate how these metrics, artifacts, and associated test procedures can be used in practice.     

Fretting wear behavior of bulk amorphous steel

Fretting wear of Fe₄₁Co₇Cr₁₅Mo₁₄C₁₅B₆Y₂ bulk metallic glass (BMG) was investigated using the ball-on-disc measurement. The wear behaviors of the samples roughly follow the classical Archard wear law at room temperature. The influence of temperature on wear resistance (R_w) and microhardness (H_v) was evaluated. A good linear correlation was found between R_w and H for the Fe-based BMG. The results indicate that the hardness softening is responsible for the decrease of R_w at high temperature. The wear mechanism at high temperature was elucidated through the analysis of oxidation and debris morphology on the wear scar. Compared with traditional crystalline steels and other non-ferrous metal-based glassy alloys, the bulk amorphous steel shows higher wear resistance and hardness, which promotes its application as an advanced engineering material.     

Influence of clay in limestone fillers for self-compacting cement based composites

High workability together with a good resistance to segregation is needed for cement based composites, specifically fresh self-compacting mortars (SCM); in this prospect, the amount of coarse materials has to be reduced and replaced by fine material. Several limestone fillers are here compared and analysed. These by-products are issued from different industrial sectors, such as the aggregate and lime production industry (quarrying operations) and the ornamental stones industry (sawing operations).Particular attention has been paid to clay content, as consistency of fresh mortars was varying, while other physical characteristics like granulometry remained the same. Relationship between the physico-chemical properties of the fillers and the properties of fresh and hardened mortars are brought forward. Even if it may affect fresh properties of mortars, results clearly show that clay type and content has minor influence than limestone filler itself.     

Probabilistic evaluation of conformity criteria for concrete families

When only a limited number of test results are available, compressive strength results of concrete family members can be combined in order to enable conformity control on a sufficient number of test results. The principles behind the conformity control of concrete families are explained and an original probabilistic evaluation of conformity criteria for concrete families is introduced. For the calculation of the corresponding operating characteristics, some approximate formulae are presented. Additionally, Monte Carlo simulation techniques are used for more exact calculations. In this way, also autocorrelation between consecutive test results can be taken into account, using an autoregressive process. The current guidelines and conformity criteria for concrete families in EN 206-1 are evaluated and discussed, based on the AOQL concept. Different conformity criteria and transformation methods are described, evaluated and discussed.     

Failure mechanisms in granular media: a discrete element analysis

This paper attempts to numerically validate the concept of diffuse failure using a discrete element method. First, the theoretical background is reviewed, and it is shown how the kinetic energy of a system, initially at rest after a loading history, is likely to abruptly increase under the effect of disturbances. The vanishing of the second-order work thus constitutes a basic ingredient, related to both the pioneering work of Hill (J Mech Phys Solids (6):236–249, 1958) and the notion of bifurcation applied to geomechanics (Vardoulakis and Sulem in Bifurcation analysis in geomechanics, Chapman & Hall Publisher, London, 1995). Discrete numerical simulations were performed on homogeneous three-dimensional specimens, and the three basic conditions that must be satisfied in order to observe a failure mechanism are numerically checked. Finally, this work illustrates the phenomena that are likely to affect in situ slopes, for instance, when the loading (due to weather conditions or human activities) meets the three basic conditions for a failure mechanism to develop.