基于UML的医院门诊管理信息系统

UML是一种重要的面向对象软件开发方法,本文简述用UML进行系统建模的方法和步骤。以医院门诊管理信息系统为例,讲述如何利用UML对其进行需求分析、系统设计、实现及测试的具体过程。     

The Golden Touch by Light: A Finely Engineered Luminogen Empowering High Photoactivatable and Photodynamic Efficiency for Cancer Phototheranostics

Photoactivatable agent is a powerful tool in biomedicine studies due to high-precision spatiotemporal control of light. However, those previously reported agents generally suffer from short wavelength, fluorescence self-quenching effect, and the lack of photosensitizing property, which severely restrict their practical applications. To address these issues, molecular engineering of 1,4-dihydropyridine derivatives is conducted to obtain an optimized agent, namely TPA-DHPy-Py, which exhibits low oxidation potential, high photoactivation efficiency, and excellent type I/II combined photodynamic activity. Concurrently, its photoactivated counterpart is featured by aggregation-induced near-infrared emission and remarkable reactive oxygen species (ROS) production efficiency. Upon photoactivation, TPA-DHPy-Py is capable of precisely identifying cancer cells from co-culturing cancer cells and normal cells without the assistance of any extra targeting units, and in situ monitoring lipid droplets and endoplasmic reticulum alteration under ROS stress, as well as achieving fluorescent visualization of tumor in vivo with supremely high imaging contrast. Furthermore, the unprecedented performance on photodynamic cancer therapy is demonstrated by the significant inhibition of tumor growth. Therefore, the photoactivatable TPA-DHPy-Py with dual-organelle-targeted and excellent photodynamic activity associated with self-monitoring ability is highly promising for cancer theranostics in clinical trials.     

A Hybrid Strategy-Based Ultra-Narrow Stretchable Microelectrodes with Cell-Level Resolution

Stretchable ultra-narrow (e.g., 10 µm in width) microelectrodes are crucial for the electrophysiological monitoring of single cells providing the fundamental understanding to the working mechanism of neuro network or other electrically functional cells. Current fabrication strategies either focus on the preparation of normal stretchable electrodes with hundreds of micrometers or millimeters in width by using inorganic conductive materials or develop conductive organic polymer gel for ultra-narrow electrodes which suffer from low stretchability and instability for long-term implantation, therefore, it is still highly desirable to explore bio-interfacial ultra-narrow stretchable inorganic electrodes. Herein, a hybrid strategy is reported to prepare ultra-narrow multi-channel stretchable microelectrodes without using photolithography or laser-assisting etching. A 10 µm × 10 µm monitoring window is fabricated with enhanced interfacial impedance by the special rough surface. The stretchability achieves to 120% for this 10 µm-width stretchable electrode. Supported by these superior properties, it is demonstrated that the stretchable microelectrodes can detect electrophysiological signals of single cells in vitro and collect electrophysiological signals more precisely in vivo. The reported strategy will open up the accessible preparation of the fine-size stretchable microelectrode. It will significantly improve the resolution of monitoring and stimulation of inorganic stretchable electrodes.     

Event-triggered-based finite-time cooperative path following control for underactuated multiple marine surface vehicles

This paper develops an event-triggered-based finite-time cooperative path following (CPF) control scheme for underactuated marine surface vehicles (MSVs) with model parameter uncertainties and unknown ocean disturbances. First, a finite-time extended state observer (FTESO) is proposed, in which the FTESO can estimate the velocities and compound disturbances in finite time. Then, the finite-time LOS guidance law based on velocity estimation values is designed to obtain the desired surge velocity and the desired yaw rate. In order to realize the cooperative control of multiple paths in finite time, the cooperative control law for the path variable is designed. In addition, the relative threshold event-triggered control (ETC) mechanism is incorporated into the formation control algorithm, and an event-triggered-based finite-time CPF controller is designed, which not only effectively reduces the update frequency of controller and the mechanical loss of actuator but also improves the control performance of system. Furthermore, by using homogeneous method, Lyapunov theory, and finite-time stability theory, it is proved that under the proposed finite-time CPF control scheme, the formation errors can converge to a small neighborhood around origin in finite time. Finally, numerical simulation results illustrate the effectiveness of the proposed control scheme.     

Evolutionary state-based novel multi-objective periodic bacterial foraging optimization algorithm for data clustering

Clustering divides objects into groups based on similarity. However, traditional clustering approaches are plagued by their difficulty in dealing with data with complex structure and high dimensionality, as well as their inability in solving multi-objective data clustering problems. To address these issues, an evolutionary state-based novel multi-objective periodic bacterial foraging optimization algorithm (ES-NMPBFO) is proposed in this article. The algorithm is designed to alleviate the high-computing complexity of the standard bacterial foraging optimization (BFO) algorithm by introducing periodic BFO. Moreover, two learning strategies, global best individual (gbest) and personal historical best individual (pbest), are used in the chemotaxis operation to enhance the convergence speed and guide the bacteria to the optimum position. Two elimination-dispersal operations are also proposed to prevent falling into local optima and improve the diversity of solutions. The proposed algorithm is compared with five other algorithms on six validity indexes in two data clustering cases comprising nine general benchmark datasets and four credit risk assessment datasets. The experimental results suggest that the proposed algorithm significantly outperforms the competing approaches. To further examine the effectiveness of the proposed strategies, two variants of ES-NMPBFO were designed, and all three forms of ES-NMPBFO were tested. The experimental results show that all of the proposed strategies are conducive to the improvement of solution quality, diversity and convergence.     

微波辅助萃取-超高效液相色谱/静电场轨道阱高分辨质谱法快速测定纺织品中有害有机溶剂残留量

建立了1个快速测定纺织品中有害有机溶剂残留量的超高效液相色谱/静电场轨道阱高分辨质谱(UPLC/Orbitrap HRMS)方法,该方法以乙醇为萃取溶剂,100℃下微波萃取纺织品中残留的有害有机溶剂,萃取液直接进行UPLC/Orbitrap HRMS,提取离子色谱峰面积外标法定量。对样品的提取条件、分析条件进行了优化。该方法的定量限为0.5μg/kg~10.0μg/kg。在3个不同加标浓度水平下,方法的平均加标回收率为81.8~94.5%,相对偏差偏差为3.8%~10.5%(n=9)。该方法简便快速,灵敏度高,定量限低,可有效地解决纺织品中残留的有害有机溶剂的快速测定问题。     

Monolithically integrated CoP nanowire array: An on/off switch for effective on-demand hydrogen generation via hydrolysis of NaBH<Subscript>4</Subscript> and NH<Subscript>3</Subscript>BH<Subscript>3</Subscript>

The issues of hydrogen generation and storage have hindered the widespread use and commercialization of hydrogen fuel cell vehicles.It is thus highly attractive,but the design and development of highly active non-noble-metal catalysts for on-demand hydrogen release from alkaline NaBH4 solution under mild conditions remains a key challenge.Herein,we describe the use of CoP nanowire array integrated on a Ti mesh (CoP NA/Ti) as a three-dimensional (3D) monolithic catalyst for efficient hydrolytic dehydrogenation of NaBH4 in basic solutions.The CoP NA/Ti works as an on/off switch for on-demand hydrogen generation at a rate of 6,500 mL/(min.g) and a low activation energy of 41 kJ/mol.It is highly robust for repeated usage after recycling,without sacrificing catalytic performance.Remarkably,this catalyst also performs efficiently for the hydrolysis of NH3BH3.     

Epitaxial growth and thermal-conductivity limit of single-crystalline Bi2Se3/In2Se3 superlattices on mica

Nano Research - Thermal transport in superlattices is governed by various phonon-scattering processes. For extracting the phonon-scattering contribution of hetero-interfaces in chalcogenide...