CFD Prediction of Flow and Homogenization in a Stirred Vessel: Part I Vessel with One and Two Impellers

A simulation of flow field and tracer homogenization was performed using the commercial CFD software FLUENT 6.1. The aim is to investigate the potential of CFD software to predict concentration distribution of added tracer in cylindrical vessels. The calculated results – dimensionless velocity profiles, power and pumping numbers, dimensionless concentration curves, and mixing times – were compared with experiments in stirred vessels. In Part I, the study was performed for vessels agitated by one or two impellers on a centric shaft. Two different impellers were used – a 6‐bladed 45° pitched blade turbine and a standard Rushton turbine. The standard k‐? turbulence model and multiple reference frames method were used for the simulations. The influence of the grid type was also investigated; three types of grid – a structured, unstructured and a special user‐defined grid – were studied.     

Rheological and drug‐release behaviour of a scleroglucan gel matrix at different drug loadings

The aim of this study was to investigate the drug‐loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2 % w/w scleroglucan gel matrix loaded with 0, 0.02, 0.04, 0.06, 0.2 and 0.4 % w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled‐stress rotational‐shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi‐empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04–0.06 % w/w Th range a plasticizing effect and in the 0.2–0.4 % w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug‐release kinetics. Copyright © 2005 Society of Chemical Industry     

Alphorn: a remote procedure call environment for fault-tolerant,heterogeneous, distributed systems

Alphorn, a software environment for programming distributed computer systems, is described. Programs running on different computers, possibly of different types and running different operating systems, communicate in a client-server relationship by means of remote procedure calls. This efficient construct structures programs neatly. The paper covers distributed process control, Alphorn's object-based programming style, remote procedure calls, the service interface language, configuration, runtime and debugging, and fault tolerance support     

Implementing total quality management at the U.S. Department of Defense

This paper examines Total Quality Management (TQM) as defined by Dr. W. Edwards Deming including Deming's fourteen points and explains how the United States' Department of Defense (DOD) defines TQM and why TQM is necessary. It also covers how the DOD is planning on implementing TQM and the policy that has been established as guidance in the implementation process.     

GELYMAC: a Macintosh application for calculating DNA fragment size from gel electrophoresis migration data

A program called GELYMAC takes data on the distances migrated by DNA fragments in a one-dimensional electrophoretic gel and, using a cubic-spline best-fit of marker fragment distance migrated versus molecular size, calculates the molecular sizes of the fragments. Written in the Rascal (Real-time Pascal) programming language, the program runs on the Macintosh family of microcomputers. Rapid entry of marker and experimental fragment migration data is afforded using a scroll bar system adjacent to a graphic representation of a gel. Output includes tabular listing of the data, graphic cartoons of the gel, and the fragment locations and molecular sizes for individual gel lanes, and the calibration curve used in data computations.     

A fine-grain architecture for relational database aggregationoperations

The design and simulation of a bit-sliced processor for relational database aggregation functions, are discussed. The processor, which addresses an important, computationally expensive problem in database computers, takes two tuples as input (one bit at a time) and returns two bits as output every clock cycle. A larger aggregation unit uses a number of identical slice processors, connected according to odd-even network topology, to achieve improved performance on a parallel pipelined processor. The data processing time is completely overlapped with the input and output of data to and from the unit. The design is independent of the tuple size, and since a bit-serial computation is used, the system requires limited interconnection     

A shell for cooperating expert systems

Abstract: This paper describes a shell for cooperating expert systems that has been developed at the University of Porto. The main goal of this shell is two-fold: to generate a community of cooperative knowledge-based systems and to develop several special reasoning techniques which can be used under a distributed and cooperative paradigm. UPShell is able to convert a set of generated intelligent systems (ISs) into a community of cooperative ISs. In this first version it is already possible to generate different intelligent systems which are able to run 'simultaneously' as separate Unix processes and, using a message-passing mechanism, to communicate among themselves. They can be set to pursue an overall goal in a cooperative way. Moreover, several tasks can be given to each IS to be solved simultaneously, and the IS can switch from task to task according to dynamic priorities reflecting the urgency attached to the specific sub-tasks that emerge. The shell described here may also be used to test, within a distributed environment, some time-bounded reasoning techniques that are presently being developed. The paper has three main parts: a general overview of the UPShell (Section 1); a tutorial explaining, by means of examples, how to use the package (Section 2); and, finally, some considerations on the reasoning techniques used and future improvements (Sections 3–5).