Characterization of pigmented granules in minocycline-induced cutaneous pigmentation: observations using fluorescence microscopy and high-performance liquid chromatography

Ambiguous abdominal situs, asplenia/polysplenia and severe cardiac malformations characterize heterotaxy in humans. These anomalies result from the inability of the developing embryo to establish normal left-right asymmetry. We have studied an interesting family in which the heterotaxy phenotype segregates as an X-linked recessive trait. In order to map the heterotaxy locus (HTX), we have analysed 39 family members using highly-polymorphic microsatellite markers from the X chromosome. One of these markers, DXS994, shows no recombination with the disease locus in 20 informative meioses. Linkage analysis results in a maximum lod score of 6.37. Current genetic and physical mapping data assign the order of loci in Xq24-q27.1 as cen-DXS1001-(DXS994, HTX)-DXS984-tel. These results establish the first mapping assignment of situs abnormalities in humans.     

An experimental and numerical investigation of ductile crack growth characteristics in surface cracked specimens under combined loading

Fracture mechanics tests have been performed in the upper shelf region of a steel on large surface cracked plate (SCT) specimens and on small compact tension (CT) specimens. Some of the SCT specimens were subjected to combined tension and bending in such a way that the loading was strongly non-proportional. Crack growth characteristics were compared between the specimens in order to assess possible influences of geometry and nonproportional loading. The differences observed could unambiguously be reduced to and correlated with differences in constraint. Constraint parameters were evaluated by detailed three-dimensional finite element computations and quantities for growing cracks were interpreted on the basis of deformation theory considerations, in analogy with the commonly used J _R-philosophy. It was noted that the initiation of ductile crack growth along a three-dimensional crack front appears to be independent of the degree of local constraint. However, the increase in toughness for a growing crack was markedly affected by the degree of local constraint. Some estimates of the constraints effects regarding stability considerations were also made.     

The association of gonorrhoea and syphilis with premature birth and low birthweight

The indications and results of single and double lung transplantation are described on the basis of 66 operations performed by the authors and on the background of the world literature. Lung transplantation is considered a new and promising therapeutic mode for treating patients with end-stage pulmonary failure related to fibrosis, emphysema, infective conditions, and pulmonary hypertension yielding satisfactory early results. The long-term prognosis of patients undergoing lung transplantation, like that of any other organ transfer, remains guarded.     

Mental health and support of women treated for breast cancer

This article presents the results of a pilot-study conducted on a small sample of women with breast cancer and the members of their social support system. The purpose was to determine the potential link between the mental health of the breast cancer patient and their support system. Mental health was assessed with the SCL-90-R (Derogatis, 1977), a self-report scale composed of 90 items divided into nine categories, offering three global indicators of distress: the Global Severity Index (GSI); the Positive Symptom Distress Index (PSDI), and the Positive Symptom Total (PST). The SCL-90-R was distributed to a sample of 14 subjects: seven women treated for breast cancer and seven significant others (social support). The results led to the definition of symptoms such as hostility, phobic anxiety and psychosis specific to either the woman or the support system.     

Radiation therapy of giant aggressive keratoacanthomas

BACKGROUND AND DESIGN: Giant aggressive keratoacanthoma is a rare destructive subset of keratoacanthoma that frequently involves the facial region, grows rapidly to a large size, and often recurs after surgical management. The effectiveness of ionizing radiation therapy was examined in a retrospective study involving 16 patients; 14 of the tumors had recurred after surgical therapy. RESULTS: All tumors resolved with satisfactory cosmetic results and without recurrence following a fractionated course of superficial radiation therapy. CONCLUSIONS: Radiation therapy is an effective therapeutic modality for giant aggressive keratoacanthomas.     

Sociopolitical effects on personality research.

Comments on L. R. Goldberg's (see record 1993-17546-001) history of the Big Five framework of personality traits and elaborated on its use. The reasons why industrial/organizational psychologists de-emphaszied the impact of personality on the job peformance in the late 1960s and 1970s and re-emphasized it in the 1980s are addressed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Tribological properties of oil-soluble polyolefins

Translated from Khimiya i Tekhnologiya Topliv i Masel, No. 11, pp. 17–18, 23, November, 1993.