The ritual as a psychotherapeutic intervention.

Examines ritual as a tool for psychotherapeutic application with clients experiencing grief, trauma, anxiety, and family dysfunction. Case vignettes are provided to illustrate the therapeutic properties and creative power of rituals as interventions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

基于异常检测的NVP表决器

一般的表决器多是针对一维输出进行表决,构建表决器相对应的决策树,预先给出阈值来制定表决策略。但是对于多维输出的表决器研究相对较少,尤其是输出各个变量之间非独立的情况下,不能将多维输出的每个变量进行单独表决,否则会引入异常点,影响表决结果。实验表明,将异常检测技术引入到表决器中,净化需要表决的数据,可以提高表决结果的准确率。     

相变存储器存储单元瞬态电流测量

介绍了相变存储单元瞬态电流的测量方法。根据相变存储器的工作特性,利用微弱电流取样电阻测量法,合理选择测量参数测得了相变存储单元的瞬态电流,电阻与电流关系特性曲线和动态电阻。并根据测量电路等效电路模型分析影响测量的因素,估算出电路中的分布电容。     

一种基于类电磁机制算法的模拟电路故障诊断方法

针对模拟电路的特征,该文提出一种基于类电磁机制算法的模拟电路故障诊断方法,该方法首先利用小波包技术提取故障特征,然后将特征向量输入到采用类电磁机制算法优化的BP神经网络中,避免参数过早陷于局部最优,提高了神经网络的分类能力.通过具体实例验证了该算法的有效性.     

基于Copula函数的洪水峰量联合设计方法研究

为明晰洪水峰量联合设计的特点,以岗南水库洪水为例,基于Gumbel Copula函数,分析了AND、OR、Kendall、生存Kendall 4种重现期的优缺点,采用极大似然法、同频率法、条件最可能组合法3种方法计算了联合设计值。结果表明: ①AND和OR重现期在危险域和安全域的识别上存在局限性;相对而言,Kendall重现期更合理,但其安全域是无界的,这与实际不符;生存Kendall重现期则界定了有界的安全域,使得重现期的概念在逻辑上更科学合理。② 3种设计值计算方法的差别不大,但从简单实用角度出发,推荐采用同频率法计算设计值。③不同重现期标准的设计值差别比较明显,基于OR重现期计算的设计值总是最大的,生存Kendall、Kendall重现期设计值次之,AND重现期设计值最小。④推荐采用生存Kendall重现期进行两变量洪水设计,因其有比较严谨的理论基础,且设计结果兼顾了安全性与经济性。⑤两变量联合设计值与单变量设计值的差异受变量间相关性的影响较大,且变量相关性越弱,差异越大。研究显示,基于生存Kendall重现期、采用同频率法计算设计值是目前较为科学合理的洪水峰量联合设计途径。     

新型矿用智能水压传感器的设计

介绍了一种基于STM32F103RBT6微控制器的新型矿用智能水压传感器的总体结构、主要硬件电路及软件设计方案。该传感器采用低功耗电路设计方式以及分时上电的供电方式,在空闲状态下功耗仅为0.006 mA,在采集发送状态下功耗约为0.5 mA。     

基于灰色支持向量机的城市用水量预测研究

研究城市用水量预测问题,城市需水量具有非线性和随机波动性,城市供水系统是复杂系统,传统灰色模型或支持向量机均无法进行准确预测。为更准确预测城市用水量,建立灰色支持向量机的城市用水量预测模型,以提高预测精度。首先采用灰色模型和支持向量机对城市用水量预测,然后采用多元线性回归确定模型权重系数,最后得到了灰色支持向量机的城市用水量预测结果。仿真结果表明,灰色支持向量机提高了城市用水量的预测精度,预测误差小于单一灰色模型和支持向量机。灰色支持向量机更好地反映出城市用水量变化的总体趋势,可为城市供水系统预测提供参考。     

Magic Peptide: Unique Properties of the LRR11 Peptide in the Activation of Leukotriene Synthesis in Human Neutrophils

Neutrophil-mediated innate host defense mechanisms include pathogen elimination through bacterial phagocytosis, which activates the 5-lipoxygenase (5-LOX) product synthesis. Here, we studied the effect of synthetic oligodeoxyribonucleotides (ODNs), which mimic the receptor-recognized sites of bacterial (CpG-ODNs) and genomic (G-rich ODNs) DNAs released from the inflammatory area, on the neutrophil functions after cell stimulation with Salmonella typhimurium. A possible mechanism for ODN recognition by Toll-like receptor 9 (TLR9) and RAGE receptor has been proposed. We found for the first time that the combination of the magic peptide LRR11 from the leucine-rich repeat (LRR) of TLR9 with the CpG-ODNs modulates the uptake and signaling from ODNs, in particular, dramatically stimulates 5-LOX pathway. Using thickness shear mode acoustic method, we confirmed the specific binding of CpG-ODNs, but not G-rich ODN, to LRR11. The RAGE receptor has been shown to play an important role in promoting ODN uptake. Thus, FPS-ZM1, a high-affinity RAGE inhibitor, suppresses the synthesis of 5-LOX products and reduces the uptake of ODNs by neutrophils; the inhibitor effect being abolished by the addition of LRR11. The results obtained revealed that the studied peptide-ODN complexes possess high biological activity and can be promising for the development of effective vaccine adjuvants and antimicrobial therapeutics.     

Adenosine Receptor Agonist HE-NECA Enhances Antithrombotic Activities of Cangrelor and Prasugrel in vivo by Decreasing of Fibrinogen Density in Thrombus

Blood platelets’ adenosine receptors (AR) are considered to be a new target for the anti-platelet therapy. This idea is based on in vitro studies which show that signaling mediated by these receptors leads to a decreased platelet response to activating stimuli. In vivo evidence for the antithrombotic activity of AR agonists published to date were limited, however, to the usage of relatively high doses given in bolus. The present study was aimed at verifying if these substances used in lower doses in combination with inhibitors of P2Y₁₂ could serve as components of dual anti-platelet therapy. We have found that a selective A_2A agonist 2-hexynyl-5’-N-ethylcarboxamidoadenosine (HE-NECA) improved the anti-thrombotic properties of either cangrelor or prasugrel in the model of ferric chloride-induced experimental thrombosis in mice. Importantly, HE-NECA was effective not only when applied in bolus as other AR agonists in the up-to-date published studies, but also when given chronically. In vitro thrombus formation under flow conditions revealed that HE-NECA enhanced the ability of P2Y₁₂ inhibitors to decrease fibrinogen content in thrombi, possibly resulting in their lower stability. Adenosine receptor agonists possess a certain hypotensive effect and an ability to increase the blood–brain barrier permeability. Therefore, the effects of anti-thrombotic doses of HE-NECA on blood pressure and the blood–brain barrier permeability in mice were tested. HE-NECA applied in bolus caused a significant hypotension in mice, but the effect was much lower when the substance was given in doses corresponding to that obtained by chronic administration. At the same time, no significant effect of HE-NECA was observed on the blood–brain barrier. We conclude that chronic administration of the A_2A agonist can be considered a potential component of a dual antithrombotic therapy. However, due to the hypotensive effect of the substances, dosage and administration must be elaborated to minimize the side-effects. The total number of animals used in the experiments was 146.     

接地铜排对变电站二次电缆防护效果研究

当变电站开关操作遭遇雷击时,接地网会产生地电位差而对二次电缆造成影响,敷设接地铜排能有效阻止电流对二次电缆的损害。基于ATP-EMTP软件建立了一个简化的变电站主接地网仿真模型,对接地铜排与主接地网的连接方式等情况进行研究,分析了接地铜排对二次电缆的防护效果。研究结果表明：增设接地铜排在一定条件下可以降低二次电缆的干扰电压,但接地铜排与主接地网有多个连接点时,在不同位置注入电流,会对电缆芯线与屏蔽层间的电压以及电缆接地点的地电位升产生不同的影响;从电缆2个接地点水平方向的内侧或外侧分别注入电流,接地铜排的影响效果相反,随着接地铜排与主接地网连接点个数的增加,电缆芯线与屏蔽层间的电压和电缆接地点地电位升分别呈增大或减小的趋势。