基于CORBA的三层结构管理信息系统的原理及实现

研究了基于CORBA的实现管理信息系统的新方法,并对其实现方法、体系结构和关键技术进行了探讨。     

激光三角法位移传感器测头设计

本文以直射式激光三角测头为例,导出了满足Scheimpfiag成象条件下的待测面位移与象位移间的准确关系,作为仪器结构参数设计的基础,并对提高测量精度和实用性的各项改进设计进行了分析。     

人-车-环境闭环模拟系统的体感模拟机理、算法及实施

根据“人－机”系统信息交换与控制的基本理论，分析了人体感知的机制，研究了体感刺激信息的模拟生成算法，建立了“人－车－环境”闭环模拟系统运动驱动软件的数学模型，编制了计算机仿真实施软件，提出了体感模拟逼真度的仿真评价方法。     

取样器测湿修正新方法

空调系统通过取样器测湿时，对结果必须修正．原有修正方法只适用于干湿球湿度计，使用不便．本文提出一种新修正方法，适用于各种类型湿度传感器．     

探索化学实验教学考评新机制

实验考核是高校化学实验教学的一个重要环节。本文以促进和提高实验教学质量为目的,概述和分析了基础实验、独立实验和综合实验三类不同层次化学实验的教学要求,提出了用建构主义理论探索实验教学考评新机制和一些有益的建议。     

Differential Cytotoxicity of Curcumin-Loaded Micelles on Human Tumor and Stromal Cells

Although curcumin in the form of nanoparticles has been demonstrated as a potential anti-tumor compound, the impact of curcumin and nanocurcumin in vitro on normal cells and in vivo in animal models is largely unknown. This study evaluated the toxicity of curcumin-loaded micelles in vitro and in vivo on several tumor cell lines, primary stromal cells, and zebrafish embryos. Breast tumor cell line (MCF7) and stromal cells (human umbilical cord vein endothelial cells, human fibroblasts, and human umbilical cord-derived mesenchymal stem cells) were used in this study. A zebrafish embryotoxicity (FET) assay was conducted following the Organisation for Economic Co-operation and Development (OECD) Test 236. Compared to free curcumin, curcumin PM showed higher cytotoxicity to MCF7 cells in both monolayer culture and multicellular tumor spheroids. The curcumin-loaded micelles efficiently penetrated the MCF7 spheroids and induced apoptosis. The nanocurcumin reduced the viability and disturbed the function of stromal cells by suppressing cell migration and tube formation. The micelles demonstrated toxicity to the development of zebrafish embryos. Curcumin-loaded micelles demonstrated toxicity to both tumor and normal primary stromal cells and zebrafish embryos, indicating that the use of nanocurcumin in cancer treatment should be carefully investigated and controlled.     

Vertebrate Animal Models of RP59: Current Status and Future Prospects

Retinitis pigmentosa-59 (RP59) is a rare, recessive form of RP, caused by mutations in the gene encoding DHDDS (dehydrodolichyl diphosphate synthase). DHDDS forms a heterotetrameric complex with Nogo-B receptor (NgBR; gene NUS1) to form a cis-prenyltransferase (CPT) enzyme complex, which is required for the synthesis of dolichol, which in turn is required for protein N-glycosylation as well as other glycosylation reactions in eukaryotic cells. Herein, we review the published phenotypic characteristics of RP59 models extant, with an emphasis on their ocular phenotypes, based primarily upon knock-in of known RP59-associated DHDDS mutations as well as cell type- and tissue-specific knockout of DHDDS alleles in mice. We also briefly review findings in RP59 patients with retinal disease and other patients with DHDDS mutations causing epilepsy and other neurologic disease. We discuss these findings in the context of addressing “knowledge gaps” in our current understanding of the underlying pathobiology mechanism of RP59, as well as their potential utility for developing therapeutic interventions to block the onset or to dampen the severity or progression of RP59.     

反向传播网络—吸光光度法同时测定生物实样中的锌和铜

研究了新显色剂 1 ,1 ,5-二 ( 2 -羟基 5 溴苯 ) 3 氰基甲日 (HBPCF)和锌及铜及铜的显色反应 ,并以反向传播人工神经网络———吸光光度法 ,对花生仁和绿豆等实际生物试样中锌及铜的含量 ,进行了同时测定。     

β-PP/PA 6合金的结晶与熔融行为

为了研究β-成核剂在合金中分散对聚丙烯（PP）成核效率的影响,采用2种方法制备了负载型β-成核剂成核PP（β-PP）／聚酰胺6（PA6）合金。用差示扫描量热仪和广角X射线衍射仪研究了不同制备方法及熔融温度对β-PP／PA6合金的结晶行为、熔融特性和β-PP含量的影响。结果表明：PP,PA6先熔融再降温至／90℃加入成核剂制备β-PP,PA6合金的β-PP含量高于先制备β-PP再与PA6混炼制备的合金。熔融温度高有利于β-PP／PA6合金中PP形成β-PP。     

面向对象技术中对象模型的复杂性

1.引言80年代多媒体应用,网络技术成就,以及各大公司推出的大量计算机辅助软件工程工具(CASE),把OO技术炒得火爆,似有90年代OO技术将会像