Microcomputer compilation and solution of crosswords

A system is described which enables crosswords to be automatically compiled or solved, or which alternatively may assist in their manual compilation or solution. Illustrative examples are quoted and the performance of the system, which has been written for an Acorn BBC model B microcomputer with disc pack and printer, is discussed.     

Complement activation in vivo in cancer patients receiving C. parvum immunotherapy

Serum complement levels were assayed in 26 patients with disseminated cancer, who received immunotherapy with infusion of C. parvum. Complement activation, indicated by the consumption of C3 or C4 or both, was found in 46% of the patients. Serum samples showed direct correlation between decreased C3 and conversion of C3 proactivator, whereas such conversion did not occur when C4 alone was decreased. It is concluded that the bypass (properdin) pathway was activated in patients in whom C3 consumption was detected, while the classical (C1) pathway was activated in the patients with C4 consumption unaccompanied by C3 decrease. Direct correlation was observed between delayed cutaneous hypersensitivity reactions to recall antigens and the incidence of C. parvum-associated complement activation.     

Time of appearance and histology of tumors induced in the dorsal skin of C3Hf mice by ultraviolet radiation from a mercury arc lamp

The time course of skin tumor induction was determined in hair-clipped inbred agouti C3Hf mice irradiated three times per week with a medium-pressure quartz-mercury lamp; 4 different UV doses were used. Although the ears were also exposed to the radiation, in the 3 groups given the highest doses no ear tumors were observed by the time each animal had developed at least 1 tumor on its back. No tumors were found in the animals receiving the lowest UV dose. In the group receiving the highest dose, males developed tumors earlier than did females; this trend continued in the lower dose groups. Many tumors that developed in the back skin were well-differentiated squamous cell carcinomas. Others were less well-differentiated squamous cell carcinomas. Others were less well defined so that the cell of origin was difficult to determine. In the group receiving the highest UV dose, the squamous cell carcinomas were few, whereas at the lower doses they predominated.     

Vibration of Tensioned Beams with Intermediate Damper. I: Formulation, Influence of Damper Location

Exact analytical solutions are formulated for free vibrations of tensioned beams with an intermediate viscous damper. The dynamic stiffness method is used in the problem formulation, and characteristic equations are obtained for both clamped and pinned supports. The complex eigenfrequencies form loci in the complex plane that originate at the undamped eigenfrequencies and terminate at the eigenfrequencies of the fully locked system, in which the damper acts as an intermediate pin support. The fully locked eigenfrequencies exhibit “curve veering,” in which adjacent eigenfrequencies approach and then veer apart as the damper passes a node of an undamped mode shape. Consideration of the evolution of the eigenfrequency loci with varying damper location reveals three distinct regimes of behavior, which prevail from the taut-string limit to the case of a beam without tension. The second regime corresponds to damper locations near the first antinode of a given undamped mode shape; in this regime, the loci bend backwards to intersect the imaginary axis, and two distinct nonoscillatory decaying solutions emerge when the damper coefficient exceeds a critical value.     

Vibration of Tensioned Beams with Intermediate Damper. II: Damper near a Support

Analytical solutions are used to investigate the free vibrations of tensioned beams with a viscous damper attached transversely near a support. This problem is of particular relevance for stay-cable vibration suppression, but no restrictions on the level of axial load are introduced, and the results are quite broadly applicable. Characteristic equations for both clamped and pinned supports are rearranged into forms suitable for numerical solution by fixed-point iteration, whereby the complex eigenfrequencies and corresponding damping ratios can be accurately computed within a few iterations. Explicit asymptotic approximations for the complex eigenfrequencies are also obtained, subject to restrictions on the closeness of the eigenfrequencies to their undamped values. These asymptotic approximations are expressed in the same “universal” form identified in previous studies. It is observed that the maximum attainable modal damping ratios and the corresponding optimal values of the damper coefficient can be significantly affected by bending stiffness and by the nature of the support conditions, and a nondimensional parameter grouping is identified that enables an assessment of when bending stiffness should be considered.     

Cell-mediated cytotoxicity: a predictor of chronic rejection in pediatric HLA haploidentical renal transplants

BACKGROUND: Recipient antidonor cytotoxic T-cell activity has been associated with graft loss and acute rejection in renal allograft recipients. The role of immunologic mechanisms in the development of chronic graft rejection is controversial. We analyzed all living related renal transplants performed at Children's Hospital (Boston, MA) from 1983 to 1995 to assess whether cell-mediated cytotoxicity, determined in vitro and measured before transplantation, was predictive of chronic rejection. METHODS: Eighty-three patients were studied retrospectively. Fifty-seven patients with one haplotype-matched renal transplants from living related donors were studied to determine the association between cell-mediated lympholysis (CML) level, acute rejection, chronic rejection, and graft failure. Acute rejection was defined by the decision to treat. Chronic rejection was defined by histology and/or the absolute serum creatinine value using an increasing serum creatinine level >1.0 mg/dl for children less than 3, a creatinine level >1.5 mg/dl for children between 3 and 10 years of age, and a creatinine level >2.0 mg/dl for children above 10 years of age. Return to dialysis or retransplantation was considered graft failure. RESULTS: Of the 57 haploidentical patients, there were 33 males and 24 females. The mean age at transplant was 11.1 years (SD=6.7). Twelve patients developed chronic rejection, 24 patients developed acute rejection, and 7 patients had graft failure. Pretransplant cytotoxic T lymphocyte activity was associated with chronic rejection (P=0.001) and graft failure (P=0.013) but only marginally with acute rejection (P=0.058). Controlling for age and sex, Cox's proportional hazards model revealed that CML level was predictive of time to chronic rejection (P<0.01) but not acute rejection (P=0.11). It was estimated that every 1-unit increase in CML level raises the monthly risk of chronic rejection by 7%. Ten children received HLA-identical kidneys from their siblings. There were no episodes of chronic rejection after 5 years. Two patients with high CML levels had episodes of acute rejection; both patients responded to treatment. CONCLUSION: Our data demonstrate an association between pretransplant cell-mediated cytotoxicity and the occurrence of chronic rejection in living related one-haploidentical renal transplants in pediatric patients.