Spinal reflex pattern to foot nociceptive stimulation in standing humans

We describe here the results of a screening program conducted to discover inhibitors of the type-I interleukin-1 receptor (IL-1RI) from samples of microbial origin. An innovative approach, based on automated, nonradioactive receptor binding assays has been employed. Specially prepared cell-free systems have allowed the use of high concentrations of microbial metabolites in the reaction mixtures with a low percentage of false positives. More than 30,000 microbial samples from different species of soil isolates have been tested and two interesting activities have been purified and characterized. One of these, isolated from Streptomyces sp. GE48009, was identified as niphimycin, an antifungal agent also known as scopafungin. Preliminary evidence suggests that this molecule and azalomycin F, a structural analogue, inhibit IL-IRI by virtue of their long-chain guanidinium moiety. The other activity, isolated from Aspergillus sp. GE49752, was identified as flavipin, a substituted o-phthalaldehyde.     

Auditory hallucinations suppressed by etizolam in a patient with schizophrenia

A patient presented with a 15 year history of schizophrenia with auditory hallucinations. Though unresponsive to prolonged trials of neuroleptics, the auditory hallucinations disappeared with etizolam.     

Robust control of permanent magnet motors: VSS techniques lead tosimple hardware implementations

It is shown how very simple velocity-tracking robust controllers for permanent magnet motors driving nonlinear loads can be designed based on variable structure systems techniques. Very fast dynamics, accurate and robust velocity-tracking are achieved with very simple hardware components without resorting to powerful digital signal processors and related interface hardware. A cascade control structure is used to ensure maximum flexibility. The controller for a DC motor is considered in great detail. Extension to AC synchronous PM motors is also presented. At the different control levels robustness is addressed with specific algorithms and the simplest solution is always selected. The controller architecture for both DC and AC synchronous motor are presented and discussed in the paper. Experimental results related to the control of a DC motor driving a nonlinear load are also shown. They demonstrate feasibility and excellent performances of the proposed approach     

The bone marrow in murine AIDS

In order to increase the understanding of blood cytopenias in HIV infection we have investigated the bone marrow in murine AIDS. C57BL/6 mice infected with the LP-BM5 retrovirus show a decrease in cellularity, numerous haemophagocytic histiocytes, a reduction of all erythroid precursor cells, an increase in eosinophil number and an increase in lymphocytes. Immunostaining with an anti-Pr60gag antibody shows that the majority of bone marrow cells express the viral protein. Thus, the bone marrow in MAIDS has many similarities with the bone marrow from patients with advanced AIDS and may prove useful as a model for therapy aimed at treating blood cytopenias.     

Investigation of the basic creep of concrete by acoustic emission

The physical origins of the basic creep of concrete are still poorly understood even though some researchers have proposed hypotheses concrening the physical mechanisms that govern this delayed behaviour of concrete. A very complete summing up of these hypotheses was produced, in the past, by, Neville; he shows that none of them, provides a satisfactory explanation of the bulk of basic creep. More recently, Rossi has proposed a new hypothesis, which has been the subject of several articles. This article concerns the use of the acoustic emission technique as a ‘tool’ to provide information on the pertinence of the physical hypothesis advanced by Rossi. The counting of the total number of acoustic events together with a frequency analysis of the acoustic emission signals indicate that there is a strong correlation between the basic creep of concrete and the creation of microcracks in the material.     

Wearable, redundant fabric-based sensor arrays for reconstruction of body segment posture

Posture and gesture analysis, together with the monitoring of body kinematics, is a field of increasing interest in bioengineering and several connected disciplines. In this paper, some typical features of distributed sensing systems are described, as well as a methodology to read signals from such systems. Theory, simulation, results, and some specific applications are shown. Strain gauges have been used as sensors and have been deposited directly onto textile fibers, demonstrating one way to realize a wearable sensor system.     

Modeling and designing processes in e-commerce applications

State-of-the-art Web applications include both navigational elements and business processes, but most Web application design methods treat business processes as just another kind of navigation. The authors' extensions to the object-oriented hypermedia design method (OOHDM) aim to remedy this situation. Rather than using navigation to emulate business processes, their new mechanisms allow developers to specify and implement processes explicitly by dealing with activity semantics and states. We describe proposed extensions to OOHDM and explore their use at an online retail store.     

Anodic oxidation of mecoprop herbicide at lead dioxide

The electrochemical oxidation of an aqueous solution containing mecoprop (2-(2-methyl-4-chlorophenoxy)propionic acid) has been studied at PbO₂ anodes by cyclic voltammetry and bulk electrolysis. The influence of current density, hydrodynamic conditions, temperature and pH on the degradation rate and current efficiency is reported. The results obtained show that the use of PbO₂ leads to total mineralization of mecoprop due to the production of oxidant hydroxyl radical electrogenerated from water discharge. The current efficiency for the electro-oxidation of mecoprop is enhanced by low current density, high recycle flow-rates and high temperature. In contrast, the pH effect was not significant. It has also been observed that mecoprop decay kinetics follows a pseudo-first-order reaction and the rate constant increases with rising current density.     

Development of calibration models for quality control in the production of ethylene/propylene copolymers by FTIR spectroscopy,multivariate statistical tools,and artificial neural networks

Principal component regression (PCR), partial least squares (PLS), StepWise ordinary least squares regression (OLS), and back‐propagation artificial neural network (BP‐ANN) are applied here for the determination of the propylene concentration of a set of 83 production samples of ethylene–propylene copolymers from their infrared spectra. The set of available samples was split into (a) a training set, for models calculation; (b) a test set, for selecting the correct number of latent variables in PCR and PLS and the end point of the training phase of BP‐ANN; (c) a production set, for evaluating the predictive ability of the models. The predictive ability of the models is thus evaluated by genuine predictions. The model obtained by StepWise OLS turned out to be the best one, both in fitting and prediction. The study of the breakdown number of samples to be included in the training set showed that at least 52 experiments are necessary to build a reliable and predictive calibration model. It can be concluded that FTIR spectroscopy and OLS can be properly employed for monitoring the synthesis or the final product of ethylene–propylene copolymers, by predicting the concentration of propylene directly along the process line. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008     

Assessment of the final metrological characteristics of a MOEMS-based NDIR spectrometer through system modeling and data processing

A model of a miniaturized non-dispersive infrared (NDIR) gas analysis system, aiming to predict the final system specifications, is presented. It comprises the different elements of the NDIR detector, including a surface micromachined Fabry-Perot tunable filter. These models have been used to estimate the response of the NDIR system to different gas mixtures. Multivariate regression methods like partial least squares allow recovering the true sample composition from the IR absorption spectra measured with the NDIR system, despite the limited selectivity of the filter. Combining model and data processing permits to predict the effect on the final system specification of design parameters. Here, we compare the effect of the technology used for the filter on the system errors.