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21.
22.
Polyunsaturated fatty acids (PUFA) were administered to 168 patients over a period of 6 months in an open-label uncontrolled study. In 129 patients available for study, 86% experienced reduction in severity, frequency and duration of migraine attacks, 22% became free of migraine and more than 90% had reduced nausea and vomiting. Self-medication changed to simple analgesics in the majority except in 14% of patients without improvement. 相似文献
23.
Selective laser sintering (SLS) uses a computer controlled laser beam to create objects directly from the CAD data without part-specific tooling. In this paper, the effect of material and processing parameters on the microstructure and mechanical properties of an alumina/aluminum phosphate composite fabricated by SLS is described. The precursor material is a blend of alumina and ammonium phosphate powder. This paper deals primarily with the effect of alumina particle size and material composition on the strength of the composite. A constitutive equation is also proposed to relate the mechanical properties of the composite to its microstructural characteristics. 相似文献
24.
GB Lipford T Sparwasser M Bauer S Zimmermann ES Koch K Heeg H Wagner 《Canadian Metallurgical Quarterly》1997,27(12):3420-3426
Certain bacterial immunostimulatory (i.s.) DNA sequences containing unmethylated CpG motifs stimulate antigen-presenting cells (APC) to express a full complement of costimulatory molecules and to produce cytokines including interleukin (IL)-12 and tumor necrosis factor (TNF)-alpha. While IL-12 is key to their T helper cell (Th)1-promoting adjuvant activity, secretion of toxic levels of TNF-alpha is harmful in that it promotes toxic shock. Given the beneficial as well as harmful consequences of i.s. DNA, we investigated the possibility of identifying DNA sequences, i.e. CpG oligodeoxynucleotides (ODN) which differentially activate IL-12 versus TNF-alpha cytokine production in APC. Here, we describe an i.s. DNA sequence with these characteristics. While its potential to induce IL-12 is preserved, its ability to trigger TNF-alpha release is strongly curtailed both in vitro and in vivo. I.s. DNA could be segregated into lethal and non-lethal in a mouse toxic shock model. The non-toxic i.s. DNA was useful as an adjuvant, thus allowing cytotoxic T cell responses to the soluble protein ovalbumin and conferring a resistant Th 1 phenotype to BALB/c mice lethally infected with Leishmania major. This i.s. CpG motif may thus be prototypic for a useful immunostimulating DNA sequence that lacks harmful side effects. 相似文献
25.
Z Amma E Kis M Józan-Jilling G Wagner T Gesztesi 《Canadian Metallurgical Quarterly》1997,138(29):1859-1861
Two chronic haemodialyzed patients with digitalis intoxication are reported. One of them took digoxin 0.25 mg three times daily for an unknown period and the other took digitoxin 0.1 mg twice daily for two weeks. The symptoms of intoxication were mainly concealed by uremic syndrome. The diagnosis was established by noticed sinus bradycardia, first- and second-degree atrioventricular block in ECG and the determination of sera levels of glycosides (serum digoxin concentration was 7.36 ng/ml, serum digitoxin concentration was 46.5 ng/ml) in both cases. Considering the probable long elimination period of digitalis and the potentially life-threatening situation the patients were given digoxin-specific antibody (Fab) fragments with potassium replacement therapy. The symptoms disappeared within a few hours after therapy, side effects and rebound toxicity did not develop. In connection with these cases the aim of this report is to publish a method which can reverse the life-threatening digitalis intoxication in patients suffering from renal failure as well. As to the above method, the authors have not found any similar case reports in the Hungarian medical literature. 相似文献
26.
We have used Path Integral Monte Carlo to study the surface melting of molecular hydrogen. Density profiles perpendicular and parallel to the bare H2 surface are computed showing the formation of a liquid adlayer at 6 K, less than half the bulk melting temperature of para-hydrogen, 13.8 K. To estimate the onset temperature and depth of H2 surface melting we determine the static structure factor within the individual H2-layers for wave vectors in the plane and find no crystalline order down to 3 K in a partially filled H2 adlayer at the free surface. We find quantum effects amplify the melting point depression at the free H2 surface compared to bulk by a factor of five over classical Lennard-Jones solids and find that the zero-point fluctuations of molecules at the surface are much enhanced over their bulk values. We see vacancy formation in the solid before melting. 相似文献
27.
Convergence of simultaneous perturbation stochastic approximation for nondifferentiable optimization 总被引:1,自引:0,他引:1
We consider simultaneous perturbation stochastic approximation for function minimization. The standard assumption for convergence is that the function be three times differentiable, although weaker assumptions have been used for special cases. However, all work that we are aware of at least requires differentiability. We relax the differentiability requirement and prove convergence using convex analysis. 相似文献
28.
T. S. Shamirzaev A. I. Toropov A. K. Bakarov K. S. Zhuravlev A. Yu. Kobitski H. P. Wagner D. R. T. Zahn 《Semiconductors》2006,40(5):527-533
The stationary and time-resolved polariton radiation in ultrahigh quality AIGaAs layers have been studied. It has been found
that elastic exciton-exciton collisions lead to the appearance of a low-energy line of polariton radiation. We show that the
rate of exciton-to-polariton transitions caused by elastic exciton-exciton collisions is determined not only by the density
of the excitonic gas, but also by its temperature; this is in accordance with existing theoretical predictions.
The text was submitted by the authors in English. 相似文献
29.
30.
JE Wagner NA Kernan M Steinbuch HE Broxmeyer E Gluckman 《Canadian Metallurgical Quarterly》1995,346(8969):214-219
Allogeneic bone marrow transplantation is limited by the availability of suitable marrow donors and risk of graft-versus-host disease (GVHD) and opportunistic infection. In an attempt to ameliorate these limitations, umbilical cord blood has been postulated as an alternative source of allogeneic haemopoietic stem cells for transplantation. From September, 1994, umbilical cord blood from sibling donors has been used to reconstitute haemapoiesis in 44 children with acquired or congenital lympho-haemapoietic disorders, neuroblastoma, or metabolic diseases. Patients who had HLA-identical and HLA-1 antigen disparate grafts, had a probability of engraftment at 50 days after transplantation of 85%. No patient had late graft failure. The probability of grade II-IV GVHD at 100 days was 3% and the probability of chronic GVHD at one year was 6%. With a median follow-up of 1.6 years, the probability of survival for recipients of HLA-identical or HLA-1 antigen disparate grafts is 72%. We conclude that umbilical cord blood is a sufficient source of transplantable haemopoietic stem cells for children with HLA-identical or HLA-1 antigen disparate sibling donors with very low risk of acute or extensive chronic GVHD. The feasibility of umbilical-cord-blood transplantation with HLA-2 and HLA-3 antigen disparate sibling donors remains to be determined. 相似文献