Fullerene: biomedical engineers get to revisit an old friend

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Fabrication of biopolymer based nanocomposite wound dressing: evaluation of wound healing properties and wound microbial load

The aim of this study is to introduce natural‐based polymers, chitosan and starch, to design a remedial nanocomposite, comprising of cerium oxide nanoparticles and silver nanoparticles, to investigate their effects in accelerating wound healing and in wound microbial load. Cerium oxide nanoparticles synthesized in starch solution added to the colloidal dispersion of synthesized silver nanoparticles in chitosan to make a three‐component nanomaterial. Mice were anaesthetized and two parallel full‐thickness round wounds were excised under aseptic conditions with the help of sterile dermal biopsy punch. Furthermore, effects of silver‐chitosan and silver‐cerium‐chitosan nanocomposite had evaluated on rate of wound closure and collagen density and on microbial load of wound in full‐thickness model. Results showed that both silver chitosan and silver‐cerium‐chitosan had significant impact on acceleration of wound closure and collagen content and on reduction of wound microbial load in comparison with control group, which was, received no treatments. However, the silver‐cerium‐chitosan nanocomposite is more potent than silver‐chitosan group and control group in wound closure. The wound healing effects of silver‐cerium‐chitosan nanocomposite are due to unique features of its three components and this nanocomposite promises impressive remedies for clinical application.Inspec keywords: wounds, nanocomposites, nanomedicine, nanoparticles, proteins, cerium, silver, polymers, colloids, patient treatmentOther keywords: biopolymer‐based nanocomposite wound dressing, wound healing properties, wound microbial load, natural‐based polymers, chitosan, remedial nanocomposite, cerium oxide nanoparticles, nanoceria, silver nanoparticles, starch solution, three‐component nanomaterial, synthesised silver nanoparticles, ketamine intraperitoneal injection, silver‐cerium‐chitosan nanocomposite, wound closure, collagen density, wound healing effects, wound care, aseptic conditions, sterile dermal biopsy punch, Ag‐Ce     

Improved electrochemical performance of nitrocarburised stainless steel by hydrogenated amorphous carbon thin films for bone tissue engineering

In this study, hydrogenated amorphous carbon thin films, structurally similar to diamond‐like carbon (DLC), were deposited on the surface of untreated and plasma nitrocarburised (Nitrocarburizing‐treated) stainless steel medical implants using a plasma‐enhanced chemical vapour deposition method. The deposited DLC thin films on the nitrocarburising‐treated implants (CN+DLC) exhibited an appropriate adhesion to the substrates. The results clearly indicated that the applied DLC thin films showed excellent pitting and corrosion resistance with no considerable damage on the surface in comparison with the other samples. The CN+DLC thin films could be considered as an efficient approach for improving the biocompatibility and chemical inertness of metallic implants.Inspec keywords: tissue engineering, bone, biomedical materials, electrochemistry, amorphous state, carbon, hydrogen, thin films, plasma CVD, adhesion, corrosion resistance, surface hardeningOther keywords: electrochemical performance, plasma nitrocarburised stainless steel medical implants, hydrogenated amorphous carbon thin films, bone tissue engineering, plasma‐enhanced chemical vapour deposition method, adhesion, corrosion resistance, biocompatibility, chemical inertness, metallic implants, C:H     

Fracture investigation of U‐notch made of tungsten–copper functionally graded materials by means of strain energy density

The averaged strain energy density over a well‐defined control volume was employed to assess the fracture of U‐notched specimens made of tungsten–copper functionally graded materials under prevalent mode II loading. The boundary of control volume was evaluated by using a numerical method. Power law function was employed to describe the mechanical properties (elasticity modulus, Poisson's ratio, fracture toughness and ultimate tensile stress) through the specimen width. The effect of notch tip radius and notch depth on notch stress intensity factors and mode mixity parameter χ were assessed. In addition, a comparison based on fracture load between functionally graded and homogeneous W–Cu was made. Furthermore, in this research, it was shown that the mean value of the strain energy density over the control volume can be accurately determined using coarse meshes for functionally graded materials.     

Developing a resilient supply chain through supplier flexibility and reliability assessment

In this study, we examine the optimal allocation of demand across a set of suppliers in a supply chain that is exposed to supply risk and environmental risk. A two-stage mixed-integer programming model is used to develop a flexible sourcing strategy under disruptions. Our model integrates supplier selection and demand allocation with transportation channel selection and provides contingency plans to mitigate the negative impacts of disruptions and minimise total network costs. Finally, a numerical example is presented to illustrate the model and provide insights. The findings suggest that developing contingency plans using flexibility in suppliers’ production capacity is an effective strategy for firms to mitigate the severity of disruptions. We also show that flexibility and reliability of the suppliers and regions play a significant role in determining contingency plans for during disruption. Findings generally show that highly flexible suppliers receive less allocation, and their flexible capacity is reserved for disruptions. For firms that do not incorporate risk management into supplier selection and allocation, the recommendation is to source from fewer, more reliable suppliers with less risk of disruption. Our findings also emphasise that the type of disruption has important implications for supplier selection and demand allocation. This study highlights the supply chain risk management strategy of regionalising as a means for minimising the impact of environmental disruptions.     

Single point incremental forming: state-of-the-art and prospects

Incremental sheet metal forming in general and Single Point Incremental Forming (SPIF) specifically have gone through a period of intensive development with growing attention from research institutes worldwide. The result of these efforts is significant progress in the understanding of the underlying forming mechanisms and opportunities as well as limitations associated with this category of flexible forming processes. Furthermore, creative process design efforts have enhanced the process capabilities and process planning methods. Also, simulation capabilities have evolved substantially. This review paper aims to provide an overview of the body of knowledge with respect to Single Point Incremental Forming. Without claiming to be exhaustive, each section aims for an up-to-date state-of-the-art review with corresponding conclusions on scientific progress and outlook on expected further developments.     

Wet Chemical Treatment and Mg Doping of p-InP Surfaces for Ohmic Low-Resistive Metal Contacts

Manufacturing a low-resistive Ohmic metal contact on p-type InP crystals for various applications is a challenge because of the Fermi-level pinning via surface defects and the diffusion of p-type doping atoms in InP. Development of wet-chemistry treatments and nanoscale control of p-doping for InP surfaces is crucial for decreasing the device resistivity losses and durability problems. Herein, a proper combination of HCl-based solution immersion, which directly provides an unusual wet chemical-induced InP(100)c(2 × 2) atomic structure, and low-temperature Mg-surface doping of the cleaned InP before Ni-film deposition is demonstrated to decrease the contact resistivity of Ni/p-InP by the factor of 10 approximately as compared to the lowest reference value without Mg. Deposition of the Mg intermediate layer on p-InP and postheating of Mg/p-InP at 350 °C, both performed in ultrahigh-vacuum (UHV) chamber, lead to intermixing of Mg and InP elements according to X-ray photoelectron spectroscopy. Introducing a small oxygen gas background (O₂ ≈ 10⁻⁶ mbar) in UHV chamber during the postheating of Mg/p-InP enhances the indium outdiffusion and provides the lowest contact resistivity. Quantum mechanical simulations indicate that the presence of InP native oxide or/and metal indium alloy at the interface increases In diffusion.     

Second Sound Measurements Near the Tricritical Point in 3He-4He Mixtures

In this paper we discuss a pulsed second sound experiment, aimed at determining accurately the critical exponent , and the predicted logarithmic correction to scaling, for the superfluid density along a tricritical path in the ³ He- ⁴ He phase diagram. We present an accurate estimate for the limits for closest approach to the tricritical point, as set by gravitationally induced sample inhomogeneities and finite size effects, and discuss some of the complications associated with measurements close to the tricritical point.     

Controlled gates for multi-level quantum computation

Multi-level (ML) quantum logic can potentially reduce the number of inputs/outputs or quantum cells in a quantum circuit which is a limitation in current quantum technology. In this paper we propose theorems about ML-quantum and reversible logic circuits. New efficient implementations for some basic controlled ML-quantum logic gates, such as three-qudit controlled NOT, Cycle, and Self Shift gates are proposed. We also propose lemmas about r-level quantum arrays and the number of required gates for an arbitrary n-qudit ML gate. An equivalent definition of quantum cost (QC) of binary quantum gates for ML-quantum gates is introduced and QC of controlled quantum gates is calculated.     

Double Auction-based Scheduling of Scientific Applications in Distributed Grid and Cloud Environments

Economy models have long been considered as a promising complement to the classical distributed resource management not only due of their dynamic and decentralized nature, but also because the concept of financial valuation of resources and services is an inherent part of any such model. In its broadest sense, scheduling of scientific applications in distributed Grid and Cloud environments can be regarded as a market-based negotiation between a scheduling service optimizing user-centric objectives (execution time, budget), and a resource manager optimizing provider-centric metrics (resource utilization, income, job throughput). In this paper, we propose a new instantiation of the negotiation protocol between the scheduler and resource manager using a market-based Continuous Double Auction (CDA) model. We analyze different scheduling strategies that can be applied and identify general strategic patterns that can lead to a fast and cheap work ow execution. In the experimental study, we demonstrate that under certain circumstances one can benefit by applying an aggressive scheduling strategy.