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101.
Mohammed Mahbubul Matin Amit R. Nath Omar Saad Mohammad M. H. Bhuiyan Farkaad A. Kadir Sharifah Bee Abd Hamid Abeer A. Alhadi Md. Eaqub Ali Wageeh A. Yehye 《International journal of molecular sciences》2016,17(9)
Benzyl α-l-rhamnopyranoside 4, obtained by both conventional and microwave assisted glycosidation techniques, was subjected to 2,3-O-isopropylidene protection to yield compound 5 which on benzoylation and subsequent deprotection of isopropylidene group gave the desired 4-O-benzoylrhamnopyranoside 7 in reasonable yield. Di-O-acetyl derivative of benzoate 7 was prepared to get newer rhamnopyranoside. The structure activity relationship (SAR) of the designed compounds was performed along with the prediction of activity spectra for substances (PASS) training set. Experimental studies based on antimicrobial activities verified the predictions obtained by the PASS software. Protected rhamnopyranosides 5 and 6 exhibited slight distortion from regular 1C4 conformation, probably due to the fusion of pyranose and isopropylidene ring. Synthesized rhamnopyranosides 4–8 were employed as test chemicals for in vitro antimicrobial evaluation against eight human pathogenic bacteria and two fungi. Antimicrobial and SAR study showed that the rhamnopyranosides were prone against fungal organisms as compared to that of the bacterial pathogens. Interestingly, PASS prediction of the rhamnopyranoside derivatives 4–8 were 0.49 < Pa < 0.60 (where Pa is probability ‘to be active’) as antibacterial and 0.65 < Pa < 0.73 as antifungal activities, which showed significant agreement with experimental data, suggesting rhamnopyranoside derivatives 4–8 were more active against pathogenic fungi as compared to human pathogenic bacteria thus, there is a more than 50% chance that the rhamnopyranoside derivative structures 4–8 have not been reported with antimicrobial activity, making it a possible valuable lead compound. 相似文献
102.
Aruni Ghose Michele Moschetta George Pappas-Gogos Matin Sheriff Stergios Boussios 《International journal of molecular sciences》2021,22(18)
Prostate cancer (PC) is the second most common cancer in men worldwide. Due to the large-scale sequencing efforts, there is currently a better understanding of the genomic landscape of PC. The identification of defects in DNA repair genes has led to clinical studies that provide a strong rationale for developing poly (ADP-ribose) polymerase (PARP) inhibitors and DNA-damaging agents in this molecularly defined subset of patients. The identification of molecularly defined subgroups of patients has also other clinical implications; for example, we now know that carriers of breast cancer 2 (BRCA2) pathogenic sequence variants (PSVs) have increased levels of serum prostate specific antigen (PSA) at diagnosis, increased proportion of high Gleason tumors, elevated rates of nodal and distant metastases, and high recurrence rate; BRCA2 PSVs confer lower overall survival (OS). Distinct tumor PSV, methylation, and expression patterns have been identified in BRCA2 compared with non-BRCA2 mutant prostate tumors. Several DNA damage response and repair (DDR)-targeting agents are currently being evaluated either as single agents or in combination in patients with PC. In this review article, we highlight the biology and clinical implications of deleterious inherited or acquired DNA repair pathway aberrations in PC and offer an overview of new agents being developed for the treatment of PC. 相似文献
103.
Matin Safa Kamaladin Gharanjig Ramin Khajavi Mojtaba Jalili 《Journal of surfactants and detergents》2013,16(1):95-104
In the study, a new treatment with cationic surfactants was proposed to remove deposited disperse dyes from polyester fabrics as an alternative to the traditional reduction clearing process. For this purpose, dodecyltrimethyl ammonium bromide and two gemini cationic surfactants (12-4-12 and 14-4-14) were investigated and the optimum operating conditions were obtained using a central composite design. Findings indicated that gemini cationic surfactants can be considered as the best candidates to remove deposited disperse dyes from polyester fabrics. This was confirmed by the results of the scanning electron microscope images, fastness properties and spectrophotometry. 相似文献
104.
Dual layer stacked rectangular microstrip patch antenna for ultra wideband applications 总被引:1,自引:0,他引:1
An antenna consisting of a U-slotted rectangular microstrip patch stacked with another patch of a different size on a separate layer is presented and its performance results are investigated. An equivalent circuit model of this stacked patch design structure is also presented based on an extended cavity model to predict the input impedance. The theoretical input impedance is evaluated from this circuit model and the experimental results support the validity of the model. In this case, stacking with a simple patch adds another resonance to the antenna thus providing a wider bandwidth. The dimension of the top patch is optimised to achieve ultra wide bandwidth. A maximum impedance bandwidth of 56.8% is achieved using this structure, and the return loss |S11|of the antenna is less than -10 dB between 3.06 and 5.49 GHz and the radiation patterns are found to be relatively constant throughout the band. A coaxial feed with Gaussian modulated pulse is used for this antenna. 相似文献
105.
We present simple changes to the cell method for neighbor list construction that enable it to be used in molecular dynamics studies of systems subject to a planar elongational flow field. The modifications for planar elongational flow are similar to those required for planar shear flow and should be easy to incorporate into any cell neighbor list method that is used in simulations of homogeneous shear. The execution time of the code at equilibrium is shown to be proportional to the number of particles N. The introduction of the modifications allowing shear, and more importantly, elongational flow are shown to affect the performance of the code in both CPU time and memory usage. The modifications to enable the simulation of planar elongational flow using the cell method of neighbor list construction will not introduce any higher order dependency if applied to code that is N-dependent in planar shear flow. We use this code to study large systems of diatomic molecules at low strain-rates, and find that the linear regime in planar elongational flow can be determined by the ratio of the two planar elongational viscosity functions. The properties investigated in planar shear flow, such as angular velocity and alignment angle, were inconsistent with the shear viscosity results in their evaluation of where the linear regime ends. The high precision of the results allowed us to accurately determine the coefficients in the retarded-motion expansion. 相似文献
106.
107.
Ya. I. Matin 《Metal Science and Heat Treatment》1969,11(9):723-725
108.
109.
110.
Seyed Sajad Mirjavadi Abdolhamid Matin Samira Rabby Behzad Mohasel Afshari 《热应力杂志》2017,40(10):1201-1214
This article presents a study on the thermal buckling behavior of two-dimensional functionally graded microbeams made of porous materials. The material composition varies along thickness and length of the microbeam based on the power law distribution. The microbeam is modeled within the framework of Euler–Bernoulli beam theory. The microbeam is considered having variable material composition along thickness. The equations are derived using the modified couple stress theory and the solving process is based on the generalized differential quadrature method. The validity of the results is shown through comparison of the results with the results of other published research. 相似文献