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41.
The massive computational resources available in the framework of a grid paradigm approach represent an emerging tool in the bioinformatics field. In this paper, we used the above approach in the rapid determination of the interactions between the ring-hydroxylating dioxygenase, comprised six enzymatic subunits, and polycyclic aromatic hydrocarbons (PAHs) in their optimal positions. The results were obtained by simulating enzyme dynamics at 300 K through molecular dynamics calculations. For the first time, the equilibrated structure of the dioxygenase revealed a network of channels throughout the enzyme that were sufficiently large to allow a flow of small ions or molecules from the inner core of the complex to its exterior surface. The ring-hydroxylating dioxygenase was able to interact with some of the studied PAHs. Additionally, not only the number of aromatic rings but also the PAH shape were critical in predicting the ability of the dioxygenase to interact with these types of molecules. Docking calculations shed light on a new possible binding site that is far from the enzymatic one, which is potentially interesting in considering the stability of the enzyme itself. 相似文献
42.
Cappelli R Ferrara M Maltoni D 《IEEE transactions on pattern analysis and machine intelligence》2010,32(12):2128-2141
In this paper, we introduce the Minutia Cylinder-Code (MCC): a novel representation based on 3D data structures (called cylinders), built from minutiae distances and angles. The cylinders can be created starting from a subset of the mandatory features (minutiae position and direction) defined by standards like ISO/IEC 19794-2 (2005). Thanks to the cylinder invariance, fixed-length, and bit-oriented coding, some simple but very effective metrics can be defined to compute local similarities and to consolidate them into a global score. Extensive experiments over FVC2006 databases prove the superiority of MCC with respect to three well-known techniques and demonstrate the feasibility of obtaining a very effective (and interoperable) fingerprint recognition implementation for light architectures. 相似文献
43.
In recent years, there has been a growing interest in developing statistical learning methods to provide approximate solutions to “difficult” control problems. In particular, randomized algorithms have become a very popular tool used for stability and performance analysis as well as for design of control systems. However, as randomized algorithms provide an efficient solution procedure to the “intractable” problems, stochastic methods bring closer to understanding the properties of the real systems. The topic of this paper is the use of stochastic methods in order to solve the problem of control robustness: the case of parametric stochastic uncertainty is considered. Necessary concepts regarding stochastic control theory and stochastic differential equations are introduced. Then a convergence analysis is provided by means of the Chernoff bounds, which guarantees robustness in mean and in probability. As an illustration, the robustness of control performances of example control systems is computed. 相似文献
44.
In systems coordinated with a distributed set of tuple spaces, it is crucial to assist agents in retrieving the tuples they are interested in. This can be achieved by sorting techniques that group similar tuples together in the same tuple space, so that the position of a tuple can be inferred by similarity. Accordingly, we formulate the collective sort problem for distributed tuple spaces, where a set of agents is in charge of moving tuples up to a complete sort has been reached, namely, each of the N tuple spaces aggregate tuples belonging to one of the N kinds available. After pointing out the requirements for effectively tackling this problem, we propose a self-organizing solution resembling brood sorting performed by ants. This is based on simple agents that perform partial observations and accordingly take decisions on tuple movement. Convergence is addressed by a fully adaptive method for simulated annealing, based on noise tuples inserted and removed by agents on a need basis so as to avoid sub-optimal sorting. Emergence of sorting properties and scalability are evaluated through stochastic simulations. 相似文献
45.
The aim of this paper is to deal with the problem of fault tolerant control in the framework of discrete event systems modeled as automata. A fault tolerant controller is a controller able to satisfy control specifications both in nominal operation and after the occurrence of a fault. This task is solved by means of a parameterized controller that is suitably updated on the basis of the information provided by online diagnostics: the supervisor actively reacts to the detection of a malfunctioning component in order to eventually meet degraded control specifications. Starting from an appropriate model of the system, we recall the notion of safe diagnosability as a necessary step in order to achieve fault tolerant control. We then introduce two new notions: (i) “safe controllability”, which represents the capability, after the occurrence of a fault, of steering the system away from forbidden zones and (ii) “active fault tolerant system”, which is the property of safely continuing operation after faults. Finally, we show how the problem can be solved using a general control architecture based on the use of special kind of diagnoser, called “diagnosing controller”, which is used to safely detect faults and to switch between the nominal control policy and a bank of reconfigured control policies. A simple example is used to illustrate the new notions and the control architecture introduced in the paper. 相似文献
46.
In the area of membrane computing, time-freeness has been defined as the ability for a timed membrane system to produce always
the same result, independently of the execution times associated to the rules. In this paper, we use a similar idea in the
framework of spiking neural P systems, a model inspired by the structure and the functioning of neural cells. In particular,
we introduce stochastic spiking neural P systems where the time of firing for an enabled spiking rule is probabilistically
chosen and we investigate when, and how, these probabilities can influence the ability of the systems to simulate, in a reliable
way, universal machines, such as register machines. 相似文献
47.
Enver Sangineto Nicola Capuano Matteo Gaeta Alessandro Micarelli 《Universal Access in the Information Society》2008,7(1-2):1-23
This paper presents an approach to automatic course generation and student modeling. The method has been developed during
the European funded projects Diogene and Intraserv, focused on the construction of an adaptive e-learning platform. The aim
of the platform is the automatic generation and personalization of courses, taking into account pedagogical knowledge on the
didactic domain as well as statistic information on both the student’s knowledge degree and learning preferences. Pedagogical
information is described by means of an innovative methodology suitable for effective and efficient course generation and
personalization. Moreover, statistic information can be collected and exploited by the system in order to better describe
the student’s preferences and learning performances. Learning material is chosen by the system matching the student’s learning
preferences with the learning material type, following a pedagogical approach suggested by Felder and Silverman. The paper
discusses how automatic learning material personalization makes it possible to facilitate distance learning access to both
able-bodied and disabled people. Results from the Diogene and Intraserv evaluation are reported and discussed. 相似文献
48.
Matteo Casadei Luca Gardelli Mirko Viroli 《Electronic Notes in Theoretical Computer Science》2007,175(2):59
Recent coordination languages and models are moving towards the application of techniques coming from the research context of complex systems: adaptivity and self-organization are exploited in order to tackle the openness, dynamism and unpredictability of today's distributed systems. In this area, systems are to be described using stochastic models, and simulation is a valuable tool both for analysis and design. Accordingly, in this work we focused on modelling and simulating emergent properties of coordination techniques.We first develop a framework acting as a general-purpose engine for simulating stochastic transition systems, built as a library for the Maude term rewriting system. We then evaluate this tool to a coordination problem called collective sort, where autonomous agents move tuples across different tuple spaces according to local criteria, and resulting in the emergence of the complete clustering property. 相似文献
49.