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排序方式: 共有1463条查询结果,搜索用时 15 毫秒
81.
Chiara Paolini Silvia Agarbati Devis Benfaremo Matteo Mozzicafreddo Silvia Svegliati Gianluca Moroncini 《International journal of molecular sciences》2022,23(7)
Systemic sclerosis (SSc) is a clinically heterogeneous disorder of the connective tissue characterized by vascular alterations, immune/inflammatory manifestations, and organ fibrosis. SSc pathogenesis is complex and still poorly understood. Therefore, effective therapies are lacking and remain nonspecific and limited to disease symptoms. In the last few years, many molecular and cellular mediators of SSc fibrosis have been described, providing new potential options for targeted therapies. In this review: (i) we focused on the PDGF/PDGFR pathway as key signaling molecules in the development of tissue fibrosis; (ii) we highlighted the possible role of stimulatory anti-PDGFRα autoantibodies in the pathogenesis of SSc; (iii) we reported the most promising PDGF/PDGFR targeting therapies. 相似文献
82.
Raffaele Raimondi Piero Zollet Francesco Paolo De Rosa Panagiotis Tsoutsanis Matteo Stravalaci Marianna Paulis Antonio Inforzato Mario R. Romano 《International journal of molecular sciences》2022,23(2)
The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular sources: induced pluripotent stem cells or embryonic stem cells. Cells can be transferred as suspension on a patch with different surgical approaches. Results are promising although based on very limited samples. In this review, we summarize the current progress of RPE replacement and provide a comparative assessment of different published approaches which may become standard of care in the future. 相似文献
83.
In this paper, a low-pressure capacitively coupled plasma discharge sustained in an argonoxygen
mixture was studied in order to evaluate its properties in terms of inactivation of
Staphylococcus aureus. The plasma parameters as electron temperature and plasma density were
measured by the Langmuir probe (Ne ≈ 1015 m−3, Te ≈ 1.5 eV), while the neutral atom density
was in the range of 1021 m−3. In the plasma phase, oxygen radicals were taken as reference of the
reactive species with antimicrobial activity, and oxygen spectral lines, over a range of plasma
process parameters, were investigated by the optical emission spectroscopy. Optimal plasma
conditions were found, and a count reduction of 4 log in a few minutes of the bacterium proves
the potentiality of an industrial grade plasma reactor as a sterilization agent. 相似文献
84.
Prevention of steel corrosion in concrete exposed to seawater with submerged sacrificial anodes 总被引:2,自引:0,他引:2
Luca Bertolini Matteo GastaldiMariaPia Pedeferri Elena Redaelli 《Corrosion Science》2002,44(7):1497-1513
This paper presents the results of a study of the effectiveness of submerged sacrificial anodes in preventing the onset of pitting corrosion in the emerged part of marine piles. Experimental tests were carried out on reinforced concrete columns with steel embedded both in chloride free concrete and chloride contaminated concrete in order to compare the effects of sacrificial anodes on passive steel and on corroding steel. Results have shown, at least under the present testing conditions, that sacrificial anodes may be more effective in preventing corrosion initiation (i.e. in providing cathodic prevention) than in controlling ongoing pitting corrosion (i.e. in guaranteeing cathodic protection). Monitoring criteria for this type of prevention are also discussed. 相似文献
85.
Gilbert D. Nessim Matteo Seita Desirée L. Plata Kevin P. O’Brien A. John Hart Eric R. Meshot Christopher M. Reddy Philip M. Gschwend Carl V. Thompson 《Carbon》2011,49(3):804-810
Despite significant progress in carbon nanotube (CNT) synthesis by thermal chemical vapor deposition (CVD), the factors determining the structure of the resulting carbon filaments and other graphitic nanocarbons are not well understood. Here, we demonstrate that gas chemistry influences the crystal structure of carbon filaments grown at low temperatures (500 °C). Using thermal CVD, we decoupled the thermal treatment of the gaseous precursors (C2H4/H2/Ar) and the substrate-supported catalyst. Varying the preheating temperature of the feedstock gas, we observed a striking transition between amorphous carbon nanofibers (CNFs) and crystalline CNTs. These results were confirmed using both a hot-wall CVD system and a cold-wall CVD reactor. Analysis of the exhaust gases (by ex situ gas chromatography) showed increasing concentrations of specific volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) that correlated with the structural transition observed (characterized using high-resolution transmission electron microscopy). This suggests that the crystallinity of carbon filaments may be controlled by the presence of specific gas phase precursor molecules (e.g., VOCs and PAHs). Thus, direct delivery of these molecules in the CVD process may enable selective CNF or CNT formation at low substrate temperatures. The inherent scalability of this approach could impact many promising applications, especially in the electronics industry. 相似文献
86.
A simple top-down fabrication technique that involves scanning probe lithography on Si is presented. The writing procedure consists of a chemically selective patterning in mesitylene. Operating in an organic media is possible to perform local oxidation or solvent decomposition during the same pass by tuning the applied bias. The layer deposited with a positively biased tip with sub-100-nm lateral resolution consists of nanocrystalline graphite, as verified by Raman spectroscopy. The oxide pattern obtained in opposite polarization is later used as a mask for dry etching, showing a remarkable selectivity in SF6 plasma, to produce Si nanofeatured molds. 相似文献
87.
88.
This paper presents a novel approach to the design of multi-/many-core systems with an adaptive level of reliability. The approach defines a layer at the operating system level that achieves fault detection/tolerance/diagnosis properties by means of thread replication and re-execution mechanisms. The layer applies the most convenient hardening mechanism to achieve the desired trade-off between reliability and performance by adapting at run-time to the changes of the working scenario. The proposed strategy has been applied in a set of experimental sessions considering a real-world parallel application, to evaluate its benefits on the final system with respect to various strategies selected at design time. 相似文献
89.
90.