Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition

Argon inhalation attenuates multiorgan failure (MOF) after experimental ischemic injury. We hypothesized that this protection could involve decreased High Mobility Group Box 1 (HMGB1) systemic release. We investigated this issue in an animal model of MOF induced by aortic cross-clamping. Anesthetized rabbits were submitted to supra-coeliac aortic cross-clamping for 30 min, followed by 300 min of reperfusion. They were randomly divided into three groups (n = 7/group). The Control group inhaled nitrogen (70%) and oxygen (30%). The Argon group was exposed to a mixture of argon (70%) and oxygen (30%). The last group inhaled nitrogen/oxygen (70/30%) with an administration of the HMGB1 inhibitor glycyrrhizin (4 mg/kg i.v.) 5 min before aortic unclamping. At the end of follow-up, cardiac output was significantly higher in Argon and Glycyrrhizin vs. Control (60 ± 4 and 49 ± 4 vs. 33 ± 8 mL/kg/min, respectively). Metabolic acidosis was attenuated in Argon and Glycyrrhizin vs. Control, along with reduced amount of norepinephrine to reverse arterial hypotension. This was associated with reduced interleukin-6 and HMGB1 plasma concentration in Argon and Glycyrrhizin vs. Control. End-organ damages were also attenuated in the liver and kidney in Argon and Glycyrrhizin vs. Control, respectively. Argon inhalation reduced HMGB1 blood level after experimental aortic cross-clamping and provided similar benefits to direct HMGB1 inhibition.     

Performances of RO and NF processes for wastewater reuse: Tertiary treatment after a conventional activated sludge or a membrane bioreactor

Wastewater reclamation requires processes and technologies having the ability to reduce the presence of micropollutants which are not wholly treated in conventional WWTP. Due to the complexity of membrane-solute interactions and the diversity of secondary treatment effluent (STE) matrices, deeper investigations are required to identify the major foulant species and more specifically their behaviour at high concentration in real waters. This study investigates the rejection and fouling potential of nanofiltration (NF) and low-pressure reverse osmosis (RO) membranes with two STEs sampled from i) a conventional activated sludge process coupled with ultrafiltration (CAS-UF) and from ii) a membrane bioreactor MBR (AquaRM^®, SAUR (France)). Whatever the origin of the effluent, RO seems to be the best solution to prevent pollution of tertiary effluents (expected result) but also to obtain low fouling levels. The different composition and molecular weight distribution of MBR and CAS-UF effluents can explain the different fouling behaviours that were observed.     

Stability of Parallel Queueing Systems with Coupled Service Rates

This paper considers a parallel system of queues fed by independent arrival streams, where the service rate of each queue depends on the number of customers in all of the queues. Necessary and sufficient conditions for the stability of the system are derived, based on stochastic monotonicity and marginal drift properties of multiclass birth and death processes. These conditions yield a sharp characterization of stability for systems where the service rate of each queue is decreasing in the number of customers in other queues, and has uniform limits as the queue lengths tend to infinity. The results are illustrated with applications where the stability region may be nonconvex.     

Feature-based approach to semi-supervised similarity learning

For the management of digital document collections, automatic database analysis still has difficulties to deal with semantic queries and abstract concepts that users are looking for. Whenever interactive learning strategies may improve the results of the search, system performances still depend on the representation of the document collection. We introduce in this paper a weakly supervised optimization of a feature vector set. According to an incomplete set of partial labels, the method improves the representation of the collection, even if the size, the number, and the structure of the concepts are unknown. Experiments have been carried out on synthetic and real data in order to validate our approach.     

3-D model-based frame interpolation for distributed video coding of static scenes.

This paper addresses the problem of side information extraction for distributed coding of videos captured by a camera moving in a 3-D static environment. Examples of targeted applications are augmented reality, remote-controlled robots operating in hazardous environments, or remote exploration by drones. It explores the benefits of the structure-from-motion paradigm for distributed coding of this type of video content. Two interpolation methods constrained by the scene geometry, based either on block matching along epipolar lines or on 3-D mesh fitting, are first developed. These techniques are based on a robust algorithm for sub-pel matching of feature points, which leads to semi-dense correspondences between key frames. However, their rate-distortion (RD) performances are limited by misalignments between the side information and the actual Wyner-Ziv (WZ) frames due to the assumption of linear motion between key frames. To cope with this problem, two feature point tracking techniques are introduced, which recover the camera parameters of the WZ frames. A first technique, in which the frames remain encoded separately, performs tracking at the decoder and leads to significant RD performance gains. A second technique further improves the RD performances by allowing a limited tracking at the encoder. As an additional benefit, statistics on tracks allow the encoder to adapt the key frame frequency to the video motion content.     

Individual cyclists' probability distributions of severe/fatal crashes in large French urban areas

The present article deals with individual cyclists’ probabilities of severe injury or death from a bicycle accident. We use an empirical Bayesian method to conduct an analysis of the fatal/severe probability distribution of a bicycle accident, at the level of individuals, in dense French urban areas. Among intuitive results, it is found that wearing a helmet lowers the average probability of such a crash; it is also shown that young bicyclists are, on average, more exposed to severe and/or fatal crashes. Finally, the results highlight a decrease of attention paid by all types of road users following road infrastructure improvements in favor of cyclists.     

Mesh-Restorable Networks with Enhanced Dual-Failure Restorability Properties

We consider extensions of the most common mesh-restorable network capacity design formulation that enhance the dual-failure restorability of the designs. A significant finding is that while design for complete dual-failure restorability can require up to triple the spare capacity, dual failure restorability can be provided for a fairly large set of priority paths with little or no more spare capacity than required for single-failure restorability. As a reference case we first study the capacity needs under complete dual-failure restorability. This shows extremely high spare capacity penalties. A second design model allows a user to specify a total capacity (or budget) limit and obtain the highest average dual-failure restorability possible for that investment limit. This formulation, and a relationship between dual-failure restorability and availability, can be used to trace-out the capacity-versus-availability trade-off curve for a mesh network. A third design strategy supports multiple-restorability service class definitions ranging from best-efforts-only to an assurance of complete single and dual-failure restorability on a per-demand basis. This lets a network operator tailor the investment in protection capacity to provide ultra-high availability on a service-selective basis, while avoiding the very high investment that would be required to support complete dual-failure restorability of the network as a whole.     

Modeling of capacitated transportation systems for integral scheduling

Motivated by a planned automated cargo transportation network, we consider transportation problems in which the finite capacity of resources (such as vehicles, docks, parking places) has to be taken into account. For such problems, it is often even difficult to construct a good feasible solution. We present a flexible modeling methodology which allows to construct, evaluate, and improve feasible solutions. This new modeling approach is evaluated on instances stemming from a simulation model of the planned cargo transportation system.Correspondence to: Marco SchuttenThe authors gratefully acknowledge the constructive comments of the anonymous referees, which helped to improve the presentation of the paper a lot.     

Mercury content in commercial pelagic fish and its risk assessment in the Western Indian Ocean

As top predators of pelagic food webs, large fish naturally bioaccumulate mercury (Hg). Determining Hg burdens in commercialized fish is essential considering the concern about effects of contaminants on human health and the legal thresholds that are therefore set for local consumption and/or exportation. Total Hg levels were measured in the muscular tissue of 183 fish of five commercially important species from the tropical zone of the Western Indian Ocean. All individuals were measured and sexed in order to study the impregnation of Hg with size and sex within each species. Values of Hg found in this part of the Indian Ocean were comparable to Hg in muscular tissue of the same species studied in other areas. The highest Hg levels were noted in Swordfish (Xiphias gladius) caught in waters surrounding Reunion Island (3.97+/-2.67 microg g(-1) dry weight). Following the Swordfish, in decreasing order of Hg content, were the Yellowfin Tuna (Thunnus albacares) and the Skipjack (Katsuwonus pelamis), then the Common Dolphinfish (Coryphaena hippurus) and the Wahoo (Acanthocybium solandri). In the North of the Mozambique Channel, Swordfish had higher Hg levels than Yellowfin Tunas, and Dolphinfish exhibited intermediate Hg levels. The size of a fish was a determining factor of its Hg burden, as was the species. Differences in size-normalized Hg levels were observed between the two study zones for Swordfish and Common Dolphinfish. Sex, in contrast, did not influence Hg levels suggesting that females and males have similar feeding habits. The muscular Hg levels presented here suggest that consumers of fish originating from the Western Indian Ocean should limit themselves to one Swordfish based meal per week, or one fish meal a day if they choose to eat tuna or Common Dolphinfish.