A method to select a successful interoperability solution through a simulation approach

Enterprise applications and software systems need to be interoperable in order to achieve seamless business across organizational boundaries and thus realize virtual networked organizations. Our proposition can be considered as an interoperability project selection approach and is based on three steps: (1) Modelling both collaborative business processes and potential related interoperability projects; (2) Evaluating the accessibility of each project regarding the current state of the organization; (3) Simulating each project and assessing the associated performance. These results are finally projected on a comparison matrix used as a decision support to select the most appropriate interoperability solution. An application case extracted from the French aerospace sector demonstrates the applicability and the benefits of the proposition.     

Development of a 3D HUD using a tunable bandpass filter for wavelength multiplexing

A 3D stereoscopic head‐up display using a tunable bandpass filter to perform left and right image spectral separation is presented. Using a single filter reduces the size and the cost of the head‐up display optical engine and enables each spectral band to be accurately tuned. Experiments performed on the first prototype demonstrate the ability to continuously tune the bandpass frequency on 30‐nm range while keeping a 20‐nm bandwidth. Such a system avoids the use of a bulky and costly rotating wheel and enables the use of holographic optical elements known to be wavelength selective.     

MetaMol: high-quality visualization of molecular skin surface

Modeling and visualizing molecular surfaces is an important and challenging task in bioinformatics. Such surfaces play an essential role in better understanding the chemical and physical properties of molecules. However, constructing and displaying molecular surfaces requires complex algorithms. In this article we introduce MetaMol, a new program that generates high-quality images in interactive time. In contrast with existing software that discretizes the surface with triangles or grids, our program is based on a GPU accelerated ray-casting algorithm that directly uses the piecewise-defined algebraic equation of the molecular skin surface. As a result, both better performances and higher quality are obtained.     

Towards a continuous microfluidic rheometer

In a previous paper we presented a way to measure the rheological properties of complex fluids on a microfluidic chip (Guillot et al., Langmuir 22:6438, 2006). The principle of our method is to use parallel flows between two immiscible fluids as a pressure sensor. In fact, in a such flow, both fluids flow side by side and the size occupied by each fluid stream depends only on both flow rates and on both viscosities. We use this property to measure the viscosity of one fluid knowing the viscosity of the other one, both flow rates and the relative size of both streams in a cross-section. We showed that using a less viscous fluid as a reference fluid allows to define a mean shear rate with a low standard deviation in the other fluid. This method allows us to measure the flow curve of a fluid with less than 250 μL of fluid. In this paper we implement this principle in a fully automated set up which controls the flow rate, analyzes the picture and calculates the mean shear rate and the viscosity of the studied fluid. We present results obtained for Newtonian fluids and complex fluids using this set up and we compare our data with cone and plate rheometer measurements. By adding a mixing stage in the fluidic network we show how this set up can be used to characterize in a continuous way the evolution of the rheological properties as a function of the formulation composition. We illustrate this by measuring the rheological curve of four formulations of polyethylene oxide solution with only 1.3 mL of concentrated polyethylene oxide solution. This method could be very useful in screening processes where the viscosity range and the behavior of the fluid to an applied stress must be evaluated.     

Locality-Sensitive Hashing for Chi2 distance

In the past 10 years, new powerful algorithms based on efficient data structures have been proposed to solve the problem of Nearest Neighbors search (or Approximate Nearest Neighbors search). If the Euclidean Locality Sensitive Hashing algorithm, which provides approximate nearest neighbors in a euclidean space with sublinear complexity, is probably the most popular, the euclidean metric does not always provide as accurate and as relevant results when considering similarity measure as the Earth-Mover Distance and 2 distances. In this paper, we present a new LSH scheme adapted to 2 distance for approximate nearest neighbors search in high-dimensional spaces. We define the specific hashing functions, we prove their local-sensitivity, and compare, through experiments, our method with the Euclidean Locality Sensitive Hashing algorithm in the context of image retrieval on real image databases. The results prove the relevance of such a new LSH scheme either providing far better accuracy in the context of image retrieval than euclidean scheme for an equivalent speed, or providing an equivalent accuracy but with a high gain in terms of processing speed.     

Multi‐objective optimization using metaheuristics: non‐standard algorithms

In recent years, the application of metaheuristic techniques to solve multi‐objective optimization problems has become an active research area. Solving this kind of problems involves obtaining a set of Pareto‐optimal solutions in such a way that the corresponding Pareto front fulfils the requirements of convergence to the true Pareto front and uniform diversity. Most of the studies on metaheuristics for multi‐objective optimization are focused on Evolutionary Algorithms, and some of the state‐of‐the‐art techniques belong this class of algorithms. Our goal in this paper is to study open research lines related to metaheuristics but focusing on less explored areas to provide new perspectives to those researchers interested in multi‐objective optimization. In particular, we focus on non‐evolutionary metaheuristics, hybrid multi‐objective metaheuristics, parallel multi‐objective optimization and multi‐objective optimization under uncertainty. We analyze these issues and discuss open research lines.     

Cantilever-based microsystem for contact and non-contact deposition of picoliter biological samples

This paper describes a cantilever-based microsystem that permits the deposition of picoliter biological samples using a contact or non-contact method. Arrays of silicon-based cantilevers have been used to produce DNA microarrays. An electrowetting-on-dielectric (EWOD) principle is applied for the loading of the liquid by controlling surface tension. Deposition is achieved by direct contact between cantilevers and the surface by capillary transport. A non-contact deposition method has also been developed. It consists in an electric-field applied between the cantilevers and a conductive surface. The results obtained demonstrate that our system meets the need for producing high-density DNA, protein and cell chips.     

Mapping the Neural Substrates Involved in Maternal Responsiveness and Lamb Olfactory Memory in Parturient Ewes Using Fos Imaging.

In sheep, recognition of the familiar lamb by the mother depends on the learning of its olfactory signature after parturition. The authors quantified Fos changes in order to identify brain regions activated during lamb odor memory formation. Brain activation was compared with those measured in anosmic ewes displaying maternal behavior but not individual lamb recognition. In intact ewes, parturition induced significant increase in Fos expression in olfactory cortical regions and in cortical amygdala, whereas in anosmic mothers, Fos expression was very low. In contrast, no difference was observed between intact and anosmic ewes in hypothalamic areas and medial amygdala, suggesting a differentiation between the neural network controlling maternal responsiveness and that involved in olfactory lamb memory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)