iLogDemons: A Demons-Based Registration Algorithm for Tracking Incompressible Elastic Biological Tissues

Tracking soft tissues in medical images using non-linear image registration algorithms requires methods that are fast and provide spatial transformations consistent with the biological characteristics of the tissues. LogDemons algorithm is a fast non-linear registration method that computes diffeomorphic transformations parameterised by stationary velocity fields. Although computationally efficient, its use for tissue tracking has been limited because of its ad-hoc Gaussian regularisation, which hampers the implementation of more biologically motivated regularisations. In this work, we improve the logDemons by integrating elasticity and incompressibility for soft-tissue tracking. To that end, a mathematical justification of demons Gaussian regularisation is proposed. Building on this result, we replace the Gaussian smoothing by an efficient elastic-like regulariser based on isotropic differential quadratic forms of vector fields. The registration energy functional is finally minimised under the divergence-free constraint to get incompressible deformations. As the elastic regulariser and the constraint are linear, the method remains computationally tractable and easy to implement. Tests on synthetic incompressible deformations showed that our approach outperforms the original logDemons in terms of elastic incompressible deformation recovery without reducing the image matching accuracy. As an application, we applied the proposed algorithm to estimate 3D myocardium strain on clinical cine MRI of two adult patients. Results showed that incompressibility constraint improves the cardiac motion recovery when compared to the ground truth provided by 3D tagged MRI.     

Towards the creation of a CNL adapted to requirements writing by combining writing recommendations and spontaneous regularities: example in a space project

The Quality Department of the French National Space Agency (CNES, Centre National d’Études Spatiales) wishes to design a writing guide based on the real and regular writing of requirements. As a first step in this project, the present article proposes a linguistic analysis of requirements written in French by CNES engineers. One of our goals is to determine to what extent they conform to several rules laid down in two existing Controlled Natural Languages (CNLs), namely the Simplified Technical English developed by the AeroSpace and Defense Industries Association of Europe and the Guide for Writing Requirements proposed by the International Council on Systems Engineering. Indeed, although CNES engineers are not obliged to follow any controlled language in their writing of requirements, we believe that language regularities are likely to emerge from this task, mainly due to the writers’ experience. We are seeking to identify these regularities in order to use them as a basis for a new CNL for the writing of requirements. The issue is approached using natural language processing tools to identify sentences that do not comply with the rules or contain specific linguistic phenomena. We further review these sentences to understand why the recommendations cannot (or should not) always be applied when specifying large-scale projects.     

Study of Nano-Porous Silicon with Low Thermal Conductivity as Thermal Insulating Material

Recently discovered phenomenon of extremely low thermal conductivity of nano-porous silicon (nano-PS) is discussed in detail. A theoretical model describing specific mechanisms of heat transport in as-prepared and oxidized nano-PS layers is described. The theoretical estimations are in a good agreement with experimental data obtained earlier. The low thermal conductivity values allow to use this promising material as thermal insulator in microsensors and microsystems. To ensure an efficient thermal isolation, a nano-PS layer has to be as thick as possible and mechanically stable. We describe here the procedures to form thick (up to 200 m) and stable nano-PS layers. Distribution of Si oxidized fraction along the layer thickness after thermal oxidation in dry O₂ atmosphere at 300°C during 1 h is studied.     

A new sarpedobilin-containing butterflyPapilio graphium stresemani stresemani and its bioecological situation within the species

The doubly cyclized bile pigment sarpedobilin (3) represents a unique case in nature. In spite of being present in trace amounts in many butterfly and moth species containing pterobilin (1) or phorcabilin (2) as the main bilin, this substance occurs as the main pigment in a restricted number of species geographically limited to Southeast Asia. We have isolated and identified sarpedobilin3 (as the dimethyl ester) as the main bile pigment fromPapilio graphium stresemani stresemani (from Ceram island, Indonesia) in the amount of ca. 0.1 mg per individual, double that found inPapilio sar-pedon orP. weiskei. We conclude thatP. sarpedon (and subspecies)P. weis-kei, andP. stresemani represent, in terms of evolution (see article), a group of closely related species. By comparison of colored wing patterns and resistance of the chromoproteins to hydrolysis by MeOH-H₂SO₄,P. stresemani is nearP. weiskei. The bioecological relationships of the three sarpedobilin-containing species is discussed.     

Estimation of the 3-D center of mass excursion from force-plate data during standing

Biomechanical models are used with force-plate information to determine the center of mass (COM) trajectory during standing. They are usually based on simplifying assumptions and are often limited to a single-plane analysis. The objectives of this study were to present a three-dimensional (3-D) model to calculate the excursion of the COM of the human body, validate it and compare its performance to a video-based system during quiet standing and antero-posterior (AP) and medio-lateral (ML) self-imposed oscillations. In addition to the vertical displacements of the COM, the originality of the method lies in eliminating the accelerations terms in the model and their related assumptions. The model was able to estimate closely the COM displacements in quiet standing [a root mean square (RMS) of 0.9 mm or less]. For the self-imposed oscillations, the RMS differences were 6.6 mm in the AP and ML directions and 1.6 mm along the vertical axis. For all three testing conditions, the coefficients of correlation of the COM displacements between the model and the video methods were above 0.8 with the exception of the vertical direction, where the values were more variable.     

Parametric study of riveted joints

As one of the most reliable fasteners, solid riveted joints are widely utilized in many industrial areas. In the present work, the authors recalled some results on the riveting process and the strength of one kind of riveted joints obtained by simulation and experimental investigations in a previous paper. The numerical results were in very good agreement with the experimental results, allowing us to validate our simulation approach and its use for further studies. We selected several engineering parameters for the riveted joint: initial assembly, friction coefficient, rivet’s geometry and sheets’ geometry, in order to carry out a parametric study and determine their relative importance. These were conducted in FEA software. The results showed the impact on riveting process and the strength of the riveted joint by varying each parameter which was interesting for the industry.     

Computing all subtree repeats in ordered trees

We consider the problem of computing all subtree repeats in a given labeled ordered tree. We first transform the tree to a string representing its postfix notation, and then present an algorithm based on the bottom-up technique to solve it. The proposed algorithm consists of two phases: the preprocessing phase and the phase where all subtree repeats are computed. The linear time and space complexity of the proposed algorithm are important parts of its quality.     

Quantitative Analysis of Tau-Microtubule Interaction Using FRET

The interaction between the microtubule associated protein, tau and the microtubules is investigated. A fluorescence resonance energy transfer (FRET) assay was used to determine the distance separating tau to the microtubule wall, as well as the binding parameters of the interaction. By using microtubules stabilized with Flutax-2 as donor and tau labeled with rhodamine as acceptor, a donor-to-acceptor distance of 54 ± 1 Å was found. A molecular model is proposed in which Flutax-2 is directly accessible to tau-rhodamine molecules for energy transfer. By titration, we calculated the stoichiometric dissociation constant to be equal to 1.0 ± 0.5 µM. The influence of the C-terminal tails of αβ-tubulin on the tau-microtubule interaction is presented once a procedure to form homogeneous solution of cleaved tubulin has been determined. The results indicate that the C-terminal tails of α- and β-tubulin by electrostatic effects and of recruitment seem to be involved in the binding mechanism of tau.     

WO3 nano-ribbons: their phase transformation from tungstite (WO3·H2O) to tungsten oxide (WO3)

Tungsten oxide (WO₃) nano-ribbons (NRs) were obtained by annealing tungstite (WO₃·H₂O) NRs. The latter was synthesized below room temperature using a simple, environmentally benign, and low cost aging treatment of precursors made by adding hydrochloric acid to diluted sodium tungstate solutions (Na₂WO₄·2H₂O). WO₃ generates significant interests and is being used in a growing variety of applications. It is therefore important to identify suitable methods of production and better understand its properties. The phase transformation was observed to be initiated between 200 and 300 ^°C, and the crystallographic structure of the NRs changed from orthorhombic WO₃·H₂O to monoclinic WO₃. It was rigorously studied by annealing a series of samples ex situ in ambient air up to 800 ^°C and characterizing them afterward. A temperature-dependent Raman spectroscopy study was performed on tungstite NRs between minus 180 and 700 ^°C. Also, in situ heating experiments in the transmission electron microscope allowed for the direct observation of the phase transformation. Powder X-ray diffraction, electron diffraction, electron energy-loss spectroscopy, and X-ray photoelectron spectroscopy were employed to characterize precisely this transformation.     

Optimization of the spark plasma sintering processing parameters affecting the properties of polyimide

The present study deals with the optimization of polyimide (PI) mechanical properties, obtained by Spark Plasma Sintering (SPS), by using a method combining Design of Experiments (DOE) with physical, structural, and mechanical characterizations. The effects of SPS parameters such as temperature, pressure, dwell time, and cooling rate on the density, mechanical properties, and structure of PI were investigated. The experimental results revealed that the mechanical properties of the material were optimized by raising the sintering temperature up to 350°C. The optimized SPS processing parameters were a temperature of 350°C, a pressure of 40 MPa, and a dwell time of 5 min. Under these conditions, a relative density of 99.6% was reached within only a few minutes. The corresponding mechanical properties consisted of Young's modulus of 3.43 GPa, a Shore D hardness of 87.3, and a compressive strength of 738 MPa for a maximum compressive strain of 61.8%. Moreover, when working at 320°C and at 100 MPa, an increase in the dwell time was necessary to enhance the properties. Contrary to the other parameters, the cooling rate appeared to be a non‐significant parameter. Finally, correlations between the PI structure and the mechanical properties were made to demonstrate the densification mechanisms. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41542.