Radiation therapy during pregnancy

A case of recovered memory of childhood trauma is reported with documented sexual trauma in early childhood, chronicled evidence of the absence of memory for traumatic experience over a period of time, and substantial evidence of 'spontaneous' recovery of memory. This account contains the first available prospective report of memory loss in a case in which there is both documented evidence of trauma and evidence of recovery of memory. The case emerged as part of a broadband, large-scale study of children followed closely from birth to adulthood which was not focused on memory for trauma. Prospective data gathered in a neutral research context, corroborated and supplemented by retrospective information, circumvent many limitations of previous retrospective accounts of recovered memories.     

Proteomic analysis of secretory proteins and vesicles in vascular research

The release of proteins and membrane vesicles in the bloodstream regulates diverse vascular processes, both physiological, such as angiogenesis and haemostasis, and pathological, such as atherosclerosis and atherothrombosis. Proteomics, beside its canonical application for the expression profiling in cells and organs, can be applied to the study of secreted proteins and microvesicles, which play a significant role in the homeostasis of the vasculature, and the development of the atherosclerotic disease.     

Car side window kinematics

It is a demanding and time-consuming task to construct the side window mechanism of a car such that the deflections along the seals are minimized. The reason for this is that the window surface S delivered by the stylist, will in general not be movable in a proper way: It is required that the surface tightly moves along the seals. Deflections will necessarily occur no matter how much effort the engineer invests. This article describes how to find a spatial motion that minimizes seal deflection for some given automobile side window surface. Necessary but acceptable modification of the stylist’s surface S is also addressed, as well as the lifting mechanism design. It is argued that our systematic approach offers considerable savings compared to the prevailing trial-and-error approach.     

Steel Desulphurisation and Sulphur Bonding in Solidified Ladle Slags

It was investigated in which form sulphur is bonded in ladle slags. For this purpose, the mineralogical phases of the ladle slags were qualitatively and quantitatively evaluated by means of a microprobe. This slag characterisation allowed reconstructing the bonding of sulphur into the phases of the ladle slag. Moreover, the reaction process with regard to the ionic theory as well as the structural formula for the mechanism of sulphur bonding were discussed. The bonding of sulphur into calcium aluminate slags is determined by the sulphide ion content in the slag as well as by the ratio of (CaO)/(Al₂O₃). Calcium sulphide separates only if the slag contains a large number of sulphide ions. When Ca₁₂Al₁₄O₃₃ is separated the sulphide ion is successively integrated into the lattice. The crystal lattice of Ca₁₂Al₁₄O₃₃ is characterised by an open, three‐dimensional anionic network composed of aluminium‐oxygen tetrahedrons linking the edges. In this network, large interstitial spaces are formed, which may be filled with calcium ions on the one hand and statistically with a free oxygen or sulphide ion on the other hand.     

The G-Protein-Coupled Estrogen Receptor (GPER/GPR30) in Ovarian Granulosa Cell Tumors

Ovarian granulosa cell tumors (GCTs) are thought to arise from cells of the ovarian follicle and comprise a rare entity of ovarian masses. We recently identified the G-protein-coupled estrogen receptor (GPER/GPR30) to be present in granulosa cells, to be regulated by gonadotropins in epithelial ovarian cancer and to be differentially expressed throughout folliculogenesis. Thus, supposing a possible role of GPER in GCTs, this study aimed to analyze GPER in GCTs. GPER immunoreactivity in GCTs (n = 26; n (primary diagnosis) = 15, n (recurrence) = 11) was studied and correlated with the main clinicopathological variables. Positive GPER staining was identified in 53.8% (14/26) of GCTs and there was no significant relation of GPER with tumor size or lymph node status. Those cases presenting with strong GPER intensity at primary diagnosis showed a significant reduced overall survival (p = 0.002). Due to the fact that GPER is regulated by estrogens, as well as gonadotropins, GPER may also be affected by endocrine therapies applied to GCT patients. Moreover, with our data supposing GPER to be associated with GCT prognosis, GPER might be considered as a possible confounder when assessing the efficacy of hormone-based therapeutic approaches in GCTs.     

Technological innovation and regional economic growth in Mexico: a spatial perspective

The aim of this investigation is to analyze the effect of technological innovation on Mexico’s regional economic growth during 1995–2007. It is argued that the inclusion of the spatial dimension in empirical analysis is still a rare practice in Mexico and even in international studies. Such inclusion allows studying the pattern of spatial interaction, the possible effects of spatial diffusion and the estimation of robust parameters. We apply the spatial data analysis methodology that has three components: (a) exploratory analysis, (b) visualization and (c) spatial econometric modeling. The main result suggests that technological innovation has a positive effect on Mexico’s regional economic growth. The empirical evidence also suggests that there is a positive effect coming from cross-border diffusion effects of technological knowledge. It also implies that states with stronger innovation activity benefited from spatial technological externalities and hence faster economic growth.