Methylene blue photocatalytic degradation under visible irradiation of Al doped ZnO powders by hydrothermal synthesis sensitized with octa-iso-pentyloxyphthalocyanine lead

AZO powders were sensitized through chemisorption method by octa-iso-pentyloxy phthalocyanine lead and characterized by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The results showed that after sensitization process AZO photo physical properties improved greatly in visible regions. Photocatalytic degradation of methylene blue was studied under visible irradiation in aqueous solution and the pseudo first order model was used to obtain kinetic information of the photocatalytic degradation. The results indicated that photocatalytic activities of PbPc(iso-PeO)₈-AZO were better than of AZO powders.     

Precise identification of moving vehicular parameters based on improved glowworm swarm optimization algorithm

This paper proposes an indirect method for the identification of moving vehicular parameters using the dynamic responses of the vehicle. The moving vehicle is modelled as 2-DOF system with 5 parameters and 4-DOF system with 12 parameters, respectively. Finite element method is used to establish the equation of the coupled bridge–vehicle system. The dynamic responses of the system are calculated by Newmark direct integration method. The parameter identification problem is transformed into an optimization problem by minimizing errors between the calculated dynamic responses of the moving vehicle and those of the simulated measured responses. Glowworm swarm optimization algorithm (GSO) is used to solve the objective function of the optimization problem. A local search method is introduced into the movement phase of GSO to enhance the accuracy and convergence rate of the algorithm. Several test cases are carried out to verify the efficiency of the proposed method and the results show that the vehicular parameters can be identified precisely with the present method and it is not sensitive to artificial measurement noise.     

The interlaminar shear failure characteristics of asphalt pavement coupled heating cables

Nowadays, heating cables are used as heat sources for heating pavements in practical engineering. However, there is a contradiction between the snow melting function and the interlaminar stability of heating pavement. In order to solve the contradiction, the interlaminar failure behavior of asphalt mixture coupled heating cables specimen (AMCS) was researched, through experiments and the finite element method. Under the different conditions of heating cables and rolling times, a series of direct shear tests was performed at the interface of AMCS, to compare the interlaminar stability of three different AMCS. Meanwhile, based on the bilinear cohesive zone model and coulomb friction model a 2D finite element model was established, to simulate this shear failure processes and make up for the limitations of the experiment. According to above test and simulation results, the failure mechanism and the weakest interface in AMCS were found, and the influence of the heating cable’s diameter and embedded spacing on the interlaminar shear strength were found. Then, a modified coulomb theorem model was proposed to predict the shear strength of the AMCS. This research enriches the design theory of the heating pavement and it has great significance for its structural design of heating asphalt pavement.     

Valorisation of mango seed via extraction of starch: preliminary techno-economic analysis

Reducing environmental impacts and obtaining economic benefits based on utilisation of waste materials are drivers for the implementation of cleaner production policies and technologies in food processing industries. Starch is a very versatile material with a wide range of applications in the food, pharmaceutical, textile, paper, cosmetic and construction industries. In Ethiopia, starch is widely used in the textile industry. To meet the starch demand, the country imports approximately 45% of the starch used in the country. Consequently, it is imperative to find additional sources of starch that could substitute for the amount of starch that is currently being imported. Mango seeds, a waste material that is disposed of after consumption of mangos, were studied for potential use as an alternative resource for starch production. The results showed that starch extraction from mango seeds was facile and a good quality product was obtained. The present study is concerned with a techno-economic analysis for industrial production of starch from mango seeds. The study shows that extraction of starch from waste mango seeds is feasible: the project is financially viable with an accounting rate of return of 83% and a break-even analysis of 78% with a payback period of 2 years.     

Unique role of non-mercapto groups in thiol-pinning-mediated Ag growth on Au nanoparticles

Owing to the strong affinity of thiols to Au and Ag, they are often employed to modify the surfaces of nanoparticles (NPs). Recently, these strong ligand-interface interactions have been employed to control NP growth, and this technique has emerged as a unique modulation strategy for creating unconventional plasmonic hybrid nanostructures. In these systems, the roles of the non-mercapto components of the thiol molecules and their structures are still unknown. Therefore, we herein present our investigation into this phenomenon. Primary amino (–NH₂) groups in thiols are found to play a key role in regulating growth kinetics, i.e., in accelerating Ag deposition on Au NPs. The–NH₂ groups are thought to bring Ag ions to the particle surface by coordinating to them, and thereby assist their reduction. The effect of molecular structure is non-trivial and thus provides the possibility of selective thiol detection. Based on the dependence of kinetic modulation on the non-mercapto components and molecular structures of molecules, we demonstrate the highly sensitive and specific detection of cysteine (limit of detection: 6 nM) in a mixture of 19 natural amino acids based on Ag growth on Au nanospheres. In addition, based on this modulation effect, we reveal the entrapping of chiral thiols within the growth layer through their plasmonic circular dichroism (PCD) responses. We believe that thiol-based growth regulation has great potential for creating plasmonic nanostructures with novel functionalities.

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Biomedical applications of mRNA nanomedicine

As an attractive alternative to plasmid DNA, messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhance translational efficacy. We also highlight recent progress in nanoparticle-based mRNA delivery. Considerable attention is given to the increasingly widespread applications of mRNA nanomedicine in the biomedical fields of vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.     

Core morphological concepts of disease for second-year medical students

With the increasing emphasis on independent learning and early patient contact, the time in the undergraduate medical curriculum for formal teaching of morphology of disease is decreasing. Thus, we thought it advisable to identify those core morphological entities of disease that should not get lost in the new paradigm. Our approach was to list all disease processes in Robbins Pathologic Basis of Diseases, 5th edition, that have distinguishing gross or microscopic characteristics. Appropriate portions of this list of 952 morphological entities from the Robbins textbook were distributed to 46 clinical specialists and pathology faculty. Each of these was asked to strongly agree, agree, disagree, or strongly disagree with the following for each entry on the list: "For purposes of developing concepts of disease, an M2 physician in training should recognize classical examples or a diagrammatic representation of the following lesions, and distinguish them from each other." Responses resulted in a consensus core list of 63 general disease process lesions and 545 organ system lesions, for a total of 608. These 608 core morphological entities were incorporated into our course by means of (1) a computer program with over 1,022 images and clinical-pathological correlations, and (2) a core list of morphological objectives for each unit in the course. In general, entities were judged noncore material if they were rare or were microscopic lesions of primary interest to pathologists and provided no major pathomorphologic concepts. The computer program as a supplement to glass slides and gross specimens has been very well accepted by students, and satisfactory performance on examinations has been maintained in spite of a 25% reduction in pathology course contact hours.     

Stress echocardiography in the study of the warm-up phenomenon

To date, the "warm-up" phenomenon in patients has been evaluated by ECG and symptom analysis. We investigated the warm-up phenomenon with supine bicycle stress echocardiography in patients with coronary artery disease documented by angiography and positive stress echocardiography. Sixteen coronary artery disease patients (54 +/- 9 years), who were off treatment throughout the study, were enrolled. Each of them underwent two consecutive exercise tests (25 W/2 min) with a 10-min recovery to reestablish baseline conditions. At the end of each stage of exercise and at peak exercise, when wall motion abnormalities (WMA), 1 mm ST depression and angina occurred, and at each minute, for the first 6 min of recovery, a 12-lead ECG was recorded and rate-pressure product was calculated. Time of onset and duration of 1 mm ST depression, WMA and angina, were also determined. Peak WMA, peak wall motion score index, duration of exercise and severity of angina were also evaluated. Exercise time duration and peak rate-pressure product were greater during the second than the first test (p = 0.02, p = 0.03 respectively); the second test also showed a longer delay of the onset of 1 mm ST depression and WMA (p = 0.01, p = 0.01 respectively) and higher rate--pressure product values (p = 0.04, p = 0.03 respectively). On the contrary, wall motion score index during the first and the second test was similar. Time to angina onset was longer during the second test (p = 0.03); the recovery period of ST depression and WMA was shorter during the second test (p = 0.02). In conclusion, these preliminary data show that patients tolerated the second period of ischemia better than the first, consistent with the presence of the warm-up phenomenon. However, the similarity of values of wall motion score index and WMA did not support a reduction in the ischemic area during the second test. This is in contrast with a possible modification of myocardial metabolism which typically underlies the ischemic preconditioning.