全文获取类型
收费全文 | 162954篇 |
免费 | 3349篇 |
国内免费 | 1213篇 |
专业分类
电工技术 | 3893篇 |
技术理论 | 1篇 |
综合类 | 1032篇 |
化学工业 | 25808篇 |
金属工艺 | 6347篇 |
机械仪表 | 5605篇 |
建筑科学 | 5372篇 |
矿业工程 | 765篇 |
能源动力 | 4167篇 |
轻工业 | 18513篇 |
水利工程 | 1394篇 |
石油天然气 | 1154篇 |
武器工业 | 120篇 |
无线电 | 21743篇 |
一般工业技术 | 30167篇 |
冶金工业 | 24183篇 |
原子能技术 | 2465篇 |
自动化技术 | 14787篇 |
出版年
2021年 | 1426篇 |
2019年 | 1190篇 |
2018年 | 1467篇 |
2017年 | 1581篇 |
2016年 | 1667篇 |
2015年 | 1678篇 |
2014年 | 2470篇 |
2013年 | 7331篇 |
2012年 | 4030篇 |
2011年 | 5514篇 |
2010年 | 4385篇 |
2009年 | 4833篇 |
2008年 | 5338篇 |
2007年 | 5527篇 |
2006年 | 4986篇 |
2005年 | 4609篇 |
2004年 | 4309篇 |
2003年 | 4152篇 |
2002年 | 4135篇 |
2001年 | 4156篇 |
2000年 | 3923篇 |
1999年 | 3872篇 |
1998年 | 6768篇 |
1997年 | 5334篇 |
1996年 | 4554篇 |
1995年 | 3782篇 |
1994年 | 3413篇 |
1993年 | 3230篇 |
1992年 | 2826篇 |
1991年 | 2712篇 |
1990年 | 2648篇 |
1989年 | 2627篇 |
1988年 | 2468篇 |
1987年 | 2173篇 |
1986年 | 2116篇 |
1985年 | 2560篇 |
1984年 | 2323篇 |
1983年 | 2195篇 |
1982年 | 2072篇 |
1981年 | 1993篇 |
1980年 | 1862篇 |
1979年 | 1875篇 |
1978年 | 1770篇 |
1977年 | 2085篇 |
1976年 | 2562篇 |
1975年 | 1583篇 |
1974年 | 1430篇 |
1973年 | 1453篇 |
1972年 | 1196篇 |
1971年 | 1115篇 |
排序方式: 共有10000条查询结果,搜索用时 296 毫秒
21.
22.
高光谱激光雷达谱位合一的角度效应分析 总被引:1,自引:0,他引:1
高光谱激光雷达以其谱位合一的技术优势为实现超三维精准遥感观测提供了可行途径,因此成为当前激光雷达与高光谱遥感领域共同大力推进的前沿发展方向。目前已有多型原型系统研发出来并得到了原理性验证,然而针对其数据处理核心环节问题的基础技术仍较为欠缺。典型问题之一是不同波段回波信号受激光入射角度的影响,该角度效应限制了高光谱激光雷达实现高性能遥感。以芬兰空间信息研究所高光谱激光雷达原型系统扫描桦树树干为例探讨了该角度效应,发现了不同激光波段对不同入射角度的回波强度响应模式,推导出了角度效应的基本规律及其精细尺度的统计规律,为后续该方向的系统研发、数据处理及信息提取等提供了可借鉴的底层机理与技术基础。 相似文献
23.
25.
Shibo Lv Yuyang Miao Dr. Dapeng Liu Prof. Fengling Song 《Chembiochem : a European journal of chemical biology》2020,21(15):2098-2110
Photothermal therapy (PTT) has attracted great attention due to its noninvasive and effective use against cancer. Various photothermal agents (PTAs) including organic and inorganic PTAs have been developed in the last decades. Organic PTAs based on small-molecule dyes exhibit great potential for future clinical applications considering their good biocompatibility and easy chemical modification or functionalization. In this review, we discuss the recent progress of organic PTAs based on small-molecule dyes for enhanced PTT. We summarize the strategies to improve the light penetration of PTAs, methods to enhance their photothermal conversion efficiency, how to optimize PTAs’ delivery into deep tumors, and how to resist photobleaching under repeated laser irradiation. We hope that this review can rouse the interest of researchers in the field of PTAs based on small-molecule dyes and help them to fabricate next-generation PTAs for noninvasive cancer therapy. 相似文献
26.
Dr. Iain J. W. McKean Prof. Paul A. Hoskisson Prof. Glenn A. Burley 《Chembiochem : a European journal of chemical biology》2020,21(20):2890-2897
This Concept article describes the latest developments in the emerging area of late-stage biocatalytic alkylation. Central to these developments is the ability to efficiently prepare S-adenosyl methionine (SAM) cofactor analogues and couple this with enzymatic alkyl transfer. Recent developments in the enzymatic synthesis of SAM cofactor analogues are summarized first, followed by their application as alkyl transfer agents catalyzed by methyltransferases (MTases). Second, innovative methods to regenerate SAM cofactors by enzymatic cascades is reported. Finally, future opportunities towards establishing a generalized platform for late-stage alkylation are described. 相似文献
27.
28.
29.
The design of a microstrip‐fed annular‐ring slot antenna (ARSA) with circular polarization (CP) radiation is initially studied. To obtain CP radiation with broad 3‐dB axial ratio (AR) bandwidth that can cover the WiMAX 2.3 GHz (2305–2320 MHz, 2345–2360 MHz) and WLAN 2.4 GHz (2400–2480 MHz) bands, a novel technique of extending an inverted L‐shaped slot from the bottom section of the annular‐ring is proposed. To suppress the harmonic modes induced by the CP ARSA, the technique of integrating a defected ground structure into the annular‐ring slot is further introduced. From the measured results, 10‐dB impedance bandwidth and 3‐dB AR bandwidth of 44.86 and 9.68% were achieved by the proposed harmonic suppressed CP ARSA. Furthermore, average gain and radiation efficiency of ~4.7 dBic and 71%, respectively, were also exhibited across the bands of interest. © 2014 Wiley Periodicals, Inc. Int J RF and Microwave CAE 25:337–345, 2015. 相似文献
30.
Steffen Vojacek Lukas Schulig Nathalie Wössner Norman Geist Prof. Dr. Walter Langel Prof. Dr. Manfred Jung Prof. Dr. Dennis Schade Prof. Dr. Andreas Link 《ChemMedChem》2019,14(8):853-864
Indoles are privileged structures in medicinal and bioorganic chemistry that are particularly well suited to serve as platforms for diversity. Among many other therapeutic areas, the indole scaffold has been used to design aromatic compounds useful to interfere with enzymes engaged in the regulation of substrate acylation status, such as sirtuins. However, the planarity of the indole ring is not necessarily optimal for all target enzymes, especially when functionalization with aromatic side chains is required. Replacement of flat scaffolds by nonplanar molecular cores dominated by sp3 hybridization is a common strategy to avoid the disadvantages associated with poor solubility and high promiscuity, while covering less-well-explored areas of chemical space. Thus, we synthesized fragment-like tetrahydroindoles suitable for fragment-based drug discovery as well as a well-characterized small library intended as multipurpose screening compounds. For proof of principle, these compounds were screened against sirtuins 1–3, enzymes known to be addressable by indoles. We found that 2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamides are potent and selective SIRT2 inhibitors. Compound 16 t displayed an IC50 value of 0.98 μm and could serve as exquisite starting point for hit-to-lead profiling. 相似文献