Parametrical analysis of the railways dynamic response at high speed moving loads

Railway Engineering Science - The paper introduces some findings about a sensitivity analysis conducted on every geometrical and mechanical parameters which characterize the use of a railway...     

Microstructural evolution and texture analysis of magnesium phosphate cement

Three-dimensional quantitative image analysis from synchrotron X-ray microcomputed tomography indicated a coarsening of the microstructure of magnesium potassium phosphate cements driven by crystallization of K-struvite from the first amorphous product. Porosity and pore surface area increased because of the progressive build-up of a network of elongated/tabular crystal domains, with density higher than the amorphous. The known increase in strength with time is thought to occur thanks to the overwhelming contribution of a developing interlocked lath-shaped microstructure. Combined X-ray and neutron diffraction texture analysis indicated that at least a fraction of K-struvite nucleates at the surface of MgO grains, suggesting the intervention of more than one crystallization mechanism. The detected weak texture, compatible with a nearly random orientation of crystallites, and the isotropic pore fabric, are beneficial with respect to crack propagation.     

Development Control And Vulnerable Coastal Lands: Examples Of Australian Practice

A range of regulatory instruments can be used to modify development-control frameworks for the purposes of adapting urban areas to climate change-induced coastal erosion and inundation. This article investigates the approach of three local governments across Australia. It finds that local governments are modifying development-control frameworks to ensure the appropriate development of vulnerable coastal lands. However, the article also demonstrates the limitations in relying on development control to achieve adaptation objectives such as preserving public beach amenity, and highlights the need for legislative reform or the emergence of incentive-based instruments to complement development control.     

Impact of BMI on Survival Outcomes of Immunotherapy in Solid Tumors: A Systematic Review

Growing research has focused on obesity as a prognostic factor during therapy with immune-checkpoint inhibitors (ICIs). The role of body-mass index (BMI) in predicting response and toxicity to ICIs is not clear, as studies have shown inconsistent results and significant interpretation biases. We performed a systematic review to evaluate the relationship between BMI and survival outcomes during ICIs, with a side focus on the incidence of immune-related adverse events (irAEs). A total of 17 studies were included in this systematic review. Altogether, the current evidence does not support a clearly positive association of BMI with survival outcomes. Regarding toxicities, available studies confirm a superimposable rate of irAEs among obese and normal weight patients. Intrinsic limitations of the analyzed studies include the retrospective nature, the heterogeneity of patients’ cohorts, and differences in BMI categorization for obese patients across different studies. These factors might explain the heterogeneity of available results, and the subsequent absence of a well-established role of baseline BMI on the efficacy of ICIs among cancer patients. Further prospective studies are needed, in order to clarify the role of obesity in cancer patients treated with immunotherapy.     

太阳能浮动岛

太阳1个小时制造的电能比整个世界1年消耗的还要多,到达地球地表的太阳能一年内的总量,可达到包括煤、石油、天然气和铀矿在内的地球上全部非可再生能源的两倍.     

甘油深加工技术

全球生物柴油产业的兴起使甘油成为丰富而廉价的天然资源,因而出现许多新的甘油深加工技术.从产业化的角度,简要地介绍了已经产业化和有产业化趋势的新的甘油深加工技术.     

反激式变换器设计优化步骤：隔离式闭环设计

由于非常复杂的AC建模和难以理解的补偿规则，隔离反激式电源的控制闭环建模和补偿级一直被认为是设计中最具挑战性的部分。设计师往往需要避免纯学术的数学方法，并依靠更多实际的实验测试结果，如负载和输入瞬态响应，或转换器开关节点的开关波形。