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101.
The present study describes the chemical composition, and antimicrobial, antioxidant and angiotensin I-converting enzyme (ACE) inhibitory activities of essential oil from Periploca laevigata root barks (PLRB), an aromatic plant widely distributed in Tunisia and used as a traditional medicinal plant. Gas chromatography/mass spectrometry was used to determine the composition of the PLRB oil. Forty-three components were identified in the essential oil and the main compounds were benzaldehyde (56%), methyl 4-methoxysalicylate (6.55%) and carvacrol (4.75%). The PLRB essential oil exhibited a dose-dependent manner of inhibitory activity toward ACE. The highest ACE inhibitory activity (54%) was observed at a concentration of 30 μg/ml. The PLRB oil was also found to possess antioxidant activities, as evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical method, β-carotene bleaching and reducing power assays. The antimicrobial activity of the essential oil was also investigated on several microorganisms. The inhibition zones and minimal inhibitory concentration (MIC) values of bacterial strains were in the range of 12–46 mm and 50–300 μg/ml, respectively. The inhibitory activity of the PLRB essential oil against Gram-positive bacteria was significantly higher than against Gram-negative. It also exhibited remarkable activity against several fungal strains. 相似文献
102.
Rafik Balti Ali Bougatef Nedra El‐Hadj Ali Dorra Zekri Ahmed Barkia Moncef Nasri 《Journal of the science of food and agriculture》2010,90(12):2006-2014
BACKGROUND: In Tunisia the cuttlefish‐processing industry generates large amounts of solid wastes. These wastes, which may represent 35% of the original material and constitute an important source of proteins, are discarded without any attempt at recovery. This paper describes some functional properties and the angiotensin I‐converting enzyme (ACE)‐inhibitory activity of protein hydrolysates prepared by hydrolysis of cuttlefish (Sepia officinalis) by‐products with crude enzyme extract from Bacillus licheniformis NH1. RESULTS: Cuttlefish by‐product protein hydrolysates (CPHs) with different degrees of hydrolysis (DH 5, 10 and 13.5%) were prepared. All CPHs contained 750–790 g kg?1 proteins. Solubility, emulsifying capacity and water‐holding capacity increased while fat absorption and foaming capacity decreased with increasing DH. All hydrolysates showed greater fat absorption than the water‐soluble fraction from undigested cuttlefish by‐product proteins and casein. CPHs were also analysed for their ACE‐inhibitory activity. CPH3 (DH 13.5%) displayed the highest ACE inhibition (79%), with an IC50 value of 1 mg mL?1. CONCLUSION: Hydrolysis of cuttlefish by‐product proteins with alkaline proteases from B. licheniformis resulted in a product with excellent solubility over a wide pH range and high ACE‐inhibitory activity. This study suggests that CPHs could be utilised to develop functional foods for prevention of hypertension. Copyright © 2010 Society of Chemical Industry 相似文献
103.
In this article, we propose a novel system for feature selection, which is one of the key problems in content-based image
indexing and retrieval as well as various other research fields such as pattern classification and genomic data analysis.
The proposed system aims at enhancing semantic image retrieval results, decreasing retrieval process complexity, and improving
the overall system usability for end-users of multimedia search engines. Three feature selection criteria and a decision method
construct the feature selection system. Two novel feature selection criteria based on inner-cluster and intercluster relations
are proposed in the article. A majority voting-based method is adapted for efficient selection of features and feature combinations.
The performance of the proposed criteria is assessed over a large image database and a number of features, and is compared
against competing techniques from the literature. Experiments show that the proposed feature selection system improves semantic
performance results in image retrieval systems.
This work was supported by the Academy of Finland, Project No. 213,462 (Finnish Centre of Excellence Program 2006–2011). 相似文献
104.
Sharon Spizzichino Giulio Mattedi Kate Lauder Coralie Valle Dr. Wahiba Aouadi Dr. Bruno Canard Dr. Etienne Decroly Dr. Suzanne J. F. Kaptein Prof. Johan Neyts Carl Graham Zakary Sule Dr. David J. Barlow Prof. Romano Silvestri Dr. Daniele Castagnolo 《ChemMedChem》2020,15(4):385-390
The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structure-based virtual screening approach using the ZIKV NS5-MTase. A novel series of molecules with a carbazoyl-aryl-urea structure has been discovered and a library of analogues has been synthesized. The new compounds inhibit ZIKV MTase with IC50 between 23–48 μM. In addition, carbazoyl-aryl-ureas also proved to inhibit ZIKV replication activity at micromolar concentration. 相似文献
105.
106.
Angiotensin I‐converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle 下载免费PDF全文
Imen Lassoued Leticia Mora Ahmed Barkia M‐Concepción Aristoy Moncef Nasri Fidel Toldrá 《International Journal of Food Science & Technology》2016,51(7):1604-1609
Angiotensin I‐converting enzyme (ACE) inhibitory peptides have been searched in thornback ray (Raja clavata) muscle hydrolysed with Bacillus subtilis A26 proteases until a hydrolysis degree of 18.35%. The hydrolysate showed an IC50 of 0.83 mg mL?1. To identify peptides responsible for this activity, the extract was eluted through size‐exclusion chromatography and fractions collected. The highest ACE inhibitory activity was found for fractions F2 and F3 which had IC50 of 0.42 and 0.51 mg mL?1, respectively. These fractions were analysed by nano‐liquid chromatography coupled to tandem mass spectrometry (nLC‐MS/MS). A total of 131 and 108 peptide sequences mainly derived from actin, myosin heavy chain and procollagen alpha 1 chain proteins were identified in fractions F2 and F3, respectively. FQPSF and LKYPI showed the best results with an IC50 of 12.56 and 27.07 μM, respectively. These results prove the potential of thornback ray muscle hydrolysate as a source of ACE inhibitory peptides. 相似文献
107.
A new lighting and daylighting control strategy is modeled and evaluated against conventional lighting and daylighting controls. The new lighting and daylighting control strategy can be incorporated in an energy management and control system (EMCS) to operate and control lighting fixtures in any indoor space. The new daylighting control can also be modeled and integrated in detailed building energy simulation tools. Through a validation analysis, it was found that the new control strategy provides more energy savings than conventional daylighting controls. Moreover, the validation analysis has indicated that existing daylighting control simulation analysis tools could overestimate lighting energy savings associated with daylighting controls. Moreover, it was also found that if calculated solar and illuminance data are used instead of measured solar radiation data, the errors in predicting lighting energy use when daylighting controls are utilized can be significant. 相似文献
108.
This paper reports on the first study of physical and mechanical properties of reactively sputtered chromium boron nitride coatings as a function of chemical composition, bias voltage and substrate temperature. Several sets of coatings were deposited by reactive unbalanced magnetron sputtering on Si(100) substrates. The chemical composition was deduced from X-ray photoelectron spectroscopy and Auger electron spectroscopy measurements, and was found to be influenced primarily by nitrogen flow rate. The phase composition was determined using X-ray diffraction in conjunction with spectroscopic ellipsometry. Atomic force microscopy was utilized to determine surface roughness and average surface grain size. Both surface roughness and surface grain size were largely independent of the nitrogen concentration and decreased with increasing bias voltage. The nanohardness and elastic modulus of each sample were measured by nanoindentation. The hardest films were produced using −150 V bias voltage and either very low (0.5-1 sccm) or very high (12-15 sccm) nitrogen flow rates. 相似文献
109.
In this paper, a novel study on system profiles and adaptation of parameters for end-users of content-based indexing and retrieval
(CBIR) applications are presented. The main objective of the study is improving the overall CBIR application performance in
different hardware platforms having different technical capabilities and conditions. We define CBIR system profiles in terms
of hardware and system platform attributes and propose CBIR parameters for each profile. Hence, the study consists of two
main parts: system profiling and adaptation of indexing and retrieval parameters for each profile. The proposed CBIR parameters
are appropriate configurations for optimal CBIR use on every platform. The proposed parameters for each system profile are
assessed over a large set of experiments. Experimental studies show that the proposed parameters for each system profile have
satisfactory semantic retrieval performance, with reduced computational complexity and storage space requirement. 45 to 78%
improvement is achieved in the computational complexity of the retrieval process depending on the profile. 相似文献
110.
Doina Petrescu Ioan Tabus Moncef Gabbouj 《Multidimensional Systems and Signal Processing》1999,10(2):161-187
This paper proposes optimal Boolean, stack, and FIR-Boolean hybrid filters for realizing the prediction stage in lossless grey-level image compression. New optimal design procedures for Boolean filters are introduced, where the optimality criterion is the Error Entropy (EE). The use of the EE-optimal and MAE-optimal Boolean and stack filters in the sequential prediction structure is considered, under different instances: global-optimal, block-optimal, adaptive-size-block-optimal and multiresolution. An extensive simulation study is carried out for analyzing and comparing the performances of the newly introduced predictors and various other sequential predictors. The EE-optimal Boolean predictors prove to be the most efficient predictors. More refined filtering structures, such as block-optimal or adaptive-size-block-optimal are suitable for the prediction task when the prediction mask ought to be small. The proposed progressive transmission structure based on optimal Boolean prediction is shown to outperform HINT HINT progressive lossless coding scheme. 相似文献