Motion study of the hip joint in extreme postures

Many causes can be at the origin of hip osteoarthritis (e.g., cam/pincer impingements), but the exact pathogenesis for idiopathic osteoarthritis has not yet been clearly delineated. The aim of the present work is to analyze the consequences of repetitive extreme hip motion on the labrum cartilage. Our hypothesis is that extreme movements can induce excessive labral deformations and lead to early arthritis. To verify this hypothesis, an optical motion capture system is used to estimate the kinematics of patient-specific hip joint, while soft tissue artifacts are reduced with an effective correction method. Subsequently, a physical simulation system is used during motion to compute accurate labral deformations and to assess the global pressure of the labrum, as well as any local pressure excess that may be physiologically damageable. Results show that peak contact pressures occur at extreme hip flexion/abduction and that the pressure distribution corresponds with radiologically observed damage zones in the labrum.

Fast Object Segmentation by Growing Minimal Paths from a Single Point on 2D or 3D Images

In this paper, we present a new method for segmenting closed contours and surfaces. Our work builds on a variant of the minimal path approach. First, an initial point on the desired contour is chosen by the user. Next, new keypoints are detected automatically using a front propagation approach. We assume that the desired object has a closed boundary. This a-priori knowledge on the topology is used to devise a relevant criterion for stopping the keypoint detection and front propagation. The final domain visited by the front will yield a band surrounding the object of interest. Linking pairs of neighboring keypoints with minimal paths allows us to extract a closed contour from a 2D image. This approach can also be used for finding an open curve giving extra information as stopping criteria. Detection of a variety of objects on real images is demonstrated. Using a similar idea, we can extract networks of minimal paths from a 3D image called Geodesic Meshing. The proposed method is applied to 3D data with promising results.

A GPU framework for parallel segmentation of volumetric images using discrete deformable models

Despite the ability of current GPU processors to treat heavy parallel computation tasks, its use for solving medical image segmentation problems is still not fully exploited and remains challenging. A lot of difficulties may arise related to, for example, the different image modalities, noise and artifacts of source images, or the shape and appearance variability of the structures to segment. Motivated by practical problems of image segmentation in the medical field, we present in this paper a GPU framework based on explicit discrete deformable models, implemented over the NVidia CUDA architecture, aimed for the segmentation of volumetric images. The framework supports the segmentation in parallel of different volumetric structures as well as interaction during the segmentation process and real-time visualization of the intermediate results. Promising results in terms of accuracy and speed on a real segmentation experiment have demonstrated the usability of the system.     

Compact yet efficient hardware implementation of artificial neural networks with customized topology

There are several neural network implementations using either software, hardware-based or a hardware/software co-design. This work proposes a hardware architecture to implement an artificial neural network (ANN), whose topology is the multilayer perceptron (MLP). In this paper, we explore the parallelism of neural networks and allow on-the-fly changes of the number of inputs, number of layers and number of neurons per layer of the net. This reconfigurability characteristic permits that any application of ANNs may be implemented using the proposed hardware. In order to reduce the processing time that is spent in arithmetic computation, a real number is represented using a fraction of integers. In this way, the arithmetic is limited to integer operations, performed by fast combinational circuits. A simple state machine is required to control sums and products of fractions. Sigmoid is used as the activation function in the proposed implementation. It is approximated by polynomials, whose underlying computation requires only sums and products. A theorem is introduced and proven so as to cover the arithmetic strategy of the computation of the activation function. Thus, the arithmetic circuitry used to implement the neuron weighted sum is reused for computing the sigmoid. This resource sharing decreased drastically the total area of the system. After modeling and simulation for functionality validation, the proposed architecture synthesized using reconfigurable hardware. The results are promising.     

Preference-based multi-objective evolutionary algorithms for power-aware application mapping on NoC platforms

Network-on-chip (NoC) are considered the next generation of communication infrastructure in embedded systems. In the platform-based design methodology, an application is implemented by a set of collaborative intellectual property (IP) blocks. The selection of the most suited set of IPs as well as their physical mapping onto the NoC infrastructure to implement efficiently the application at hand are two hard combinatorial problems that occur during the synthesis process of Noc-based embedded system implementation. In this paper, we propose an innovative preference-based multi-objective evolutionary methodology to perform the assignment and mapping stages. We use one of the well-known and efficient multi-objective evolutionary algorithms NSGA-II and microGA as a kernel. The optimization processes of assignment and mapping are both driven by the minimization of the required silicon area and imposed execution time of the application, considering that the decision maker’s preference is a pre-specified value of the overall power consumption of the implementation.     

Form-Profiling of Optics Using the Geometry Measuring Machine and the M-48 CMM at NIST

We are developing an instrument, the Geometry Measuring Machine (GEMM), to measure the profile errors of aspheric and free form optical surfaces, with measurement uncertainties near 1 nm. Using GEMM, an optical profile is reconstructed from local curvatures of a surface, which are measured at points on the optic’s surface. We will describe a prototype version of GEMM, its repeatability with time, a measurements registry practice, and the calibration practice needed to make nanometer resolution comparisons with other instruments. Over three months, the repeatability of GEMM is 3 nm rms, and is based on the constancy of the measured profile of an elliptical mirror with a radius of curvature of about 83 m. As a demonstration of GEMM’s capabilities for curvature measurement, profiles of that same mirror were measured with GEMM and the NIST Moore M-48 coordinate measuring machine. Although the methods are far different, two reconstructed profiles differ by 22 nm peak-to-valley, or 6 nm rms. This comparability clearly demonstrates that with appropriate calibration, our prototype of the GEMM can measure complex-shaped optics.     

Genotoxicity of recycling electronic waste in Idhna,Hebron District,Palestine

Most Electronic waste (e-waste) ends up in landfills while some is recycled. A major site for e-waste recycling in Palestine is the village of Idhna in the Hebron District and most of this waste originates from Israel. The objective of this study was to evaluate the effects of e-waste on human DNA damage and chromosome breaks. The test sample was 46 non-smoker individuals with direct exposure to e-waste, either employed in the workshops or resident in Idhna. Genotoxicity data were compared with a control sample of sixteen unexposed individuals from Bethlehem and Al-Aizariya (Bethany). DNA damage was evaluated using the Comet assay while chromosome aberrations were tested by using conventional cytogenetic techniques. We noted an average of 4.83 aberration/cell/subject in test samples while in controls the average was 0.75. Chromosome aberration frequency was statistically different between exposed and control samples for total aberrations, for chromatid and chromosome breaks, and for formation of rings but not for dicenterics and tetraploidy. The Comet assay likewise showed that there was significant difference between exposed and control samples for DNA damage (p < 0.05). We therefore recommend measures to mitigate the health impact of e-waste recycling.     

Mimetic Discretizations of Elliptic Control Problems

We investigate the performance of the Mimetic Finite Difference (MFD) method for the approximation of a constraint optimal control problem governed by an elliptic operator. Low-order and high-order mimetic discretizations are considered and a priori error estimates are derived, in a suitable discrete norm, for both the control and the state variables. A wide class of numerical experiments performed on a set of examples selected from the literature assesses the robustness of the MFD method and confirms the convergence analysis.     

Nisin as a Food Preservative: Part 1: Physicochemical Properties,Antimicrobial Activity,and Main Uses

Nisin is a natural preservative for many food products. This bacteriocin is mainly used in dairy and meat products. Nisin inhibits pathogenic food borne bacteria such as Listeria monocytogenes and many other Gram-positive food spoilage microorganisms. Nisin can be used alone or in combination with other preservatives or also with several physical treatments. This paper reviews physicochemical and biological properties of nisin, the main factors affecting its antimicrobial effectiveness, and its food applications as an additive directly incorporated into food matrices.