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61.
Generally the most real world production systems are tackling several different responses and the problem is optimizing these responses concurrently. This study strives to present a new two-phase hybrid genetic based metaheuristic for optimizing nonlinear continuous multi-response problems. Premature convergence and getting stuck in local optima, which makes the algorithm time consuming, are common problems dealing with genetic algorithms (GAs). So we hybridize GA with a clustering approach and particle swarm optimization algorithm (PSO) to make a balanced relationship between time consuming and premature termination. The proposed algorithm also tries to find Ideal Points (IPs) for response functions. IPs are considered as improvement measures that determine when PSO should start. PSO based local search exploit Pareto archive solutions to enhance performance of the algorithm by expanding the search space. Since there is no standard benchmark in this field, we use two case studies from distinguished paper in multi-response optimization and compare the results with some of the mentioned algorithms in the literature. Results show the outperformance of the proposed algorithm than all of them. 相似文献
62.
As whole flaxseed is beneficial in the treatment of experimental renal disease, we undertook a study to determine whether
previously documented benefits of whole flaxseed could be reproduced with dietary low-lignan flax oil (FO), a rich source
of α-linolenic acid, in experimental polycystic kidney disease. Male offspring of Han:SPRD-cy heterozygous rats were fed a synthetic diet containing FO or corn oil (CO) for 8 wk from the time of weaning. Renal inflammation,
fibrosis, proliferation, cystic change, and oxidized-LDL were assessed morphometrically. Hepatic and renal lipid composition
was assessed using GC. FO feeding produced hepatic and renal enrichment of n−3 PUFA and an increase in C18∶>C18 PUFA ratios
(18-carbon PUFA compared to longer-chain PUFA), with a reduction in proportion of hepatic long-chain PUFA. The FO-based diet
was associated with lower mean cystic change by 29.7% (P=0.018), fibrosis by 21.7% (P=0.017), macrophage infiltration by 31.5% (P< 0.0001), epithelial proliferation by 18.7% (P=0.0035), and ox-LDL detection by 31.4% (P<0.0001) in Han:SPRD-cy heterozygotes. Serum creatinine was significantly lower in FO-fed diseased animals. A small hypocholesterolemic effect was
noted in all animals fed FO. FO feeding moderates renal injury, modifies the profile of substrates available for elongation
to eicosanoid precursors, and inhibits the elongation of C18 PUFA in this model. The consumption of FO-based products may prove a more practical way of obtaining health benefit than
attempts to increase dietary content of unrefined seed. 相似文献
63.
64.
Tanya Singh Adam S. Neal Neda A. Moatamed Sanaz Memarzadeh 《International journal of molecular sciences》2021,22(1)
One of the major challenges in the treatment of cancer are differential responses of patients to existing standard of care anti-cancer drugs. These differential responses may, in part, be due to a diverse range of genomic, epigenomic, proteomic, and metabolic alterations among individuals suffering from the same type of cancer. Precision medicine is an emerging approach in cancer therapeutics that takes into account specific molecular alterations, environmental factors as well as lifestyle of individual patients. This approach allows clinicians and researchers to select or predict treatments that would most likely benefit the patient based on their individual tumor characteristics. One class of precision medicine tools are predictive, in vitro drug-response assays designed to test the sensitivity of patient tumor cells to existing or novel therapies. These assays have the potential to rapidly identify the most effective treatments for cancer patients and thus hold great promise in the field of precision medicine. In this review, we have highlighted several drug-response assays developed in ovarian cancer and discussed the current challenges and future prospects of these assays in the clinical management of this disease. 相似文献
65.
66.
Manavizadeh Neda Rabbani Masoud Radmehr Farzad 《The International Journal of Advanced Manufacturing Technology》2015,79(1-4):415-425
The International Journal of Advanced Manufacturing Technology - Mixed model production is the practice of assembling different and distinct models in a line without changeovers responding to... 相似文献
67.
Neda Farnad Reza Heidari Behnaz Aslanipour 《Sensing and Instrumentation for Food Quality and Safety》2014,8(2):113-121
Peppermint (Mentha piperita) has long been regarded as a food and medicinal plant. At the present work, the antioxidant activity of the methanol, ethanol and methanol/ethanol (1:1) extracts of leaf fraction through various in vitro models was investigated in Iranian peppermints for the first time. Total phenol, flavonoid and anthocyanin contents were also determined. Our results showed the alcoholic extracts had different responses with different antioxidant methods. The methanol extract had maximum phenol content (3.57 ± 0.26 g Gallic acid/100 g Peppermint powder) and showed best superoxide radical (47.05 ± 0.85 %) and hydrogen peroxide (91.05 ± 1.50 %) scavenging activities. The methanol/ethanol (1:1) extract had maximum flavonoid (3.33 ± 0.12 g quercetin/100 g Peppermint powder) and anthocyanin contents (1.74 ± 0.21 g/100 g Peppermint powder) and showed best DPPH radical scavenging activity (82.82 ± 2.57 %, IC50 = 10.02 ± 0.63 mg/mL) as well as ferric reducing power (184.22 ± 14.10 μmol/100 g Peppermint powder). The ethanol extract only showed the highest nitric oxide radical scavenging activity (80.13 ± 7.12 %). Chlorogenic acid, rutin, and caffeic acid were found by HPLC analysis of the main phenolic components. These results show, Peppermint alcoholic extracts can be used as a natural antioxidants to reduce oxidative stress in human beings and as a possible food supplement or in pharmaceutical applications. 相似文献
68.
Mišan A Mimica-Dukić N Sakač M Mandić A Sedej I Simurina O Tumbas V 《Journal of food science》2011,76(9):C1239-C1244
The antioxidant activity of ethanolic extracts of parsley, buckthorn, mint, caraway, and their mixture "Vitalplant" was evaluated, and the potential of "Vitalplant" mixture extract to retard the process of lipid oxidation in cookies was tested. The antioxidant activity was estimated by 2 direct (ESR) and 4 indirect (spectrophotometric) tests and correlated with the total phenolic and flavonoid content. The potential of "Vitalplant" mixture extract to retard the process of lipid oxidation in cookies was measured by thiobarbituric acid (TBA)-reactive-substances assay (TBARS) and DPPH˙ (1,1-diphenyl-2-picryl-hydrazyl) test. Significantly different (P < 0.05) amounts of total phenolics were found among extracts in the following order: mint > buckthorn > "Vitalplant" > parsley > caraway. Total flavonoid content varied from 0.510% (parsley) to 2.05% ("Vitalplant"). A statistically significant correlation was found between IC(50) values on DPPH˙ and total flavonoid content of the samples (r=- 0.94, P < 0.05) and between IC(50) values on DPPH˙ and IC(50) values on O(2) (·-) scavenging activity (r= 0.89, P < 0.05). A correlation between reducing activity and total phenolic content was found to be positive and statistically significant (r= 0.94, P < 0.05). "Vitalplant" mixture exhibited a relatively high antioxidant activity in most of the tests, which can be explained by synergistic effects of the ingredients of which it is composed. Finally, "Vitalplant" extract addition (2%, 4%, and 6%) improved antioxidant activity and oxidative stability of the cookies in dose-dependent manner. PRACTICAL APPLICATION: Supplementation of cookies with a mixture of Petroselini fructus, Frangulae cortex, Mentha piperitae folium, Carvi fructus can retard the process of lipid oxidation and elevate antioxidant activity of the final product. 相似文献
69.
Reza Hosseini Neda Teimourzadeh Morteza Fathipour 《Journal of Computational Electronics》2014,13(1):170-179
A new type of Gate All Around Nanowire Transistor (GAA NWT) which employs source heterojunction and strained channel is proposed and its electrical characteristics are compared with SiGe GAA NWT and with conventional Silicon GAA NWT. The effect of band-offset energy at the source SiGe/strained-Si heterojunction is to enhance carriers’ kinetic energy when injected from the source into the channel. In this analysis, a quantum mechanical transport approach based on non-equilibrium Green’s function method in the frame work of effective mass theory is employed. Simulation routine consists of self consistent solutions of a three dimensional Poisson’s equation, a Schrodinger equation on the radial direction, and also transport equation. We analyze the electrical characteristics of the source heterojunction strained channel GAA NWT. Also, the advantages of this novel structure in terms of current drive capability and conduction band edge are discussed. It is shown that proposed structure provides a higher on current, lower leakage, lower threshold voltage and lower subthreshold slope in comparison with SiGe GAA NWT and conventional Silicon GAA NWT. 相似文献
70.
Ignacija Vlai Anela Horvat Ana Tadijan Neda Slade 《International journal of molecular sciences》2023,24(1)
Metastatic melanoma is one of the most aggressive tumors, with frequent mutations affecting components of the MAPK pathway, mainly protein kinase BRAF. Despite promising initial response to BRAF inhibitors, melanoma progresses due to development of resistance. In addition to frequent reactivation of MAPK or activation of PI3K/AKT signaling pathways, recently, the p53 pathway has been shown to contribute to acquired resistance to targeted MAPK inhibitor therapy. Canonical tumor suppressor p53 is inactivated in melanoma by diverse mechanisms. The TP53 gene and two other family members, TP63 and TP73, encode numerous protein isoforms that exhibit diverse functions during tumorigenesis. The p53 family isoforms can be produced by usage of alternative promoters and/or splicing on the C- and N-terminus. Various p53 family isoforms are expressed in melanoma cell lines and tumor samples, and several of them have already shown to have specific functions in melanoma, affecting proliferation, survival, metastatic potential, invasion, migration, and response to therapy. Of special interest are p53 family isoforms with increased expression and direct involvement in acquired resistance to MAPK inhibitors in melanoma cells, implying that modulating their expression or targeting their functional pathways could be a potential therapeutic strategy to overcome resistance to MAPK inhibitors in melanoma. 相似文献