Mechano mathematical models for mechatronic systems for vibration jaw crushing processes

The aim of this paper is creation, investigation of mono frequency and poly frequency plane and spatial vibrations of two mass vibration systems with a suitable adjustment of the mechanical system. The physical object is a vibrating jaw crusher. The mechanical and mathematical modeling is created on the basis of a two mass dynamic model with six degrees of freedom in plane case—three for each mass and 12 degrees of freedom in spatial model—six for each mass. The influence of the elastic linkages between the two masses and also the energy mutual linkages between the coordinates of the two bodies are investigated.

Natural frequencies and amplitudes of movement are obtained by means of computer experiment in plane and spatial aspect. The obtained results can be used for optimization of the constructive parameters of the vibrating jaw crusher and also for improving harmful resonance effects     

ENZYMIC PROTEIN HYDROLYSATES FROM MALT SPROUTS

Recent literature on the use of malt sprouts is reviewed. Studies on the hydrolysis of malt sprouts by alkaline protease were carried out to determine the optimal conditions required. Under these conditions an overall 40% solubilisation of the malt sprouts was achieved which incorporated a 65% solubilisation of the total protein content. Amino nitrogen content of the malt sprouts reached 0.8% on hydrolysis. The extract from the hydrolysed malt sprouts contained approximately 40% hydrolysed protein, 40% dextrins and salts. Evaporation of this extract produces a viscous syrup and spray drying produces a hydroscopic powder containing 1.8–2.0% amino nitrogen. The protein part of the hydrolysate extract is balanced with respect to its essential amino acid content and has a low bitter taste. Data from experiments carried out on the effect of the extract on yeast fermentation indicate a significant stimulation and possible applications in the food industry.     

Effects of Combined Allogenic Adipose Stem Cells and Hyperbaric Oxygenation Treatment on Pathogenesis of Osteoarthritis in Knee Joint Induced by Monoiodoacetate

The beneficial effects of HBO in inflammatory processes make it an attractive type of treatment for chronic arthritis. In addition, the effects of combination therapy based on adipose stem cells and HBO on OA progression have not been fully investigated. The current study explored the efficacy of intra-articular injection of allogeneic adipose-derived mesenchymal stem cells (ADMSCs) combined with hyperbaric oxygenation treatment (HBO) in a rat osteoarthritis (OA) model. The rat OA model was induced by intra-articular injection of monoiodoacetate (MIA) and 7 days after application of MIA rats were divided into five groups: healthy control (CTRL), osteoarthritis (OA), ADMSCs (ADS), the HBO+ADS^21day and HBO+ADS^28day groups. A single dose of 1 × 10⁶ allogeneic ADMSCs suspended in sterile saline was injected into the knee joint alone or in combination with HBO treatment. Rats were sacrificed at 3 or 4 weeks after MIA injection. Treatment outcomes were evaluated by radiographic, morphological and histological analysis and by specific staining of articular cartilage. We also measured the level of inflammatory and pro/antioxidative markers. We confirmed that combined treatment of ADMSCs and HBO significantly improved the regeneration of cartilage in the knee joint. Rtg score of knee joint damage was significantly decreased in the HBO+ADS^21day and HBO+ADS^28day groups compared to the OA. However, the positive effect in the HBO+ADS^28day group was greater than the HBO+ADS^21day group. The articular cartilage was relatively normal in the HBO+ADS^28day group, but moderate degeneration was observed in the HBO+ADS^21day compared to the OA group. These findings are in line with the histopathological results. A significantly lower level of O₂⁻. was observed in the HBO+ADS^28day group but a higher NO level compared to the HBO+ADS^21day group. Moreover, in the HBO+ADS^28day group significantly higher concentrations of IL-10 were observed but there was no significant difference in proinflammatory cytokine in serum samples. These results indicate that a single intra-articular injection of allogeneic ADMSCs combined with HBO efficiently attenuated OA progression after 28 days with greater therapeutic effect compared to alone ADMSCs or after 3 weeks of combined treatment. Combined treatment might be an effective treatment for OA in humans.