Energy sustainability indicators for local energy planning: Review of current practices and derivation of a new framework

Tackling climate change is a growing concern of our society. Although action is needed at all levels of governance, local authorities play a key role in climate action. The creation of sustainable energy and climate action plans at the local level are recent trends that show increasing local commitment. During the last decade, several municipalities have started to develop plans, but surprisingly little systematic technical guidance has been provided to them. As part of an effort to develop tools to assist energy planning at the local level, this study addresses the role of indicators in energy planning. This paper aims to propose a framework of local energy sustainability indicators to be used both as an assessment and as an action-planning tool. A literature review of existing sets of sustainability indicators and the testing of the selected indicators with pilot municipalities has led to a framework composed by 18 indicators. The indicators proposed were developed by having into consideration, besides relevance, their potential use as decision criteria for identifying the most effective actions for local energy planning. The paper also investigates the presence of the proposed indicators in existing local sustainability assessment initiatives and energy and climate action plans as well as the purpose for which they were being used in the plans. The analysis of 10 local energy and climate action plans has revealed that local authorities are using indicators mostly for diagnosis purposes, paying less attention to monitoring. Using indicators as decision criteria to choose the actions to be included in the action plan is not yet a common practice. It was also found that only a small number of the indicators proposed in this paper were already considered in the action plans analysed.     

Conversion of aqueous extracts from thermochemical treatment of bagasse into functional emulsifiers

Synthetic emulsifiers in food industries are being replaced with a customer-friendly food ingredient that is derived from biomass using sustainable green technologies. After hydrothermal liquefaction treatment, raw bagasse (21%), pith (26%), and rind portions (25%) were obtained with reduced ash contents. As aqueous extracts, with oligosaccharides and lignin residues, it was used in the preparation of oil-in-water emulsions with 5% soybean oil. Results showed that the emulsions stabilised the oil droplets with particle size between 11 and 17 µm by steric repulsion with raw bagasse-stabilised emulsion showing a better stability at 25 °C (31 days). It was demonstrated that raw bagasse extracts, without alteration, maybe a potential unconventional source for food-grade emulsifiers by integrating a versatile thermochemical conversion of waste without the use of chemicals.     

Multiaxial fatigue of quenched and tempered U2 steel: Testing and fatigue life prediction

Tension‐compression, tension‐tension, torsional, and 90° out‐of‐phase axial‐torsional fatigue tests were performed on a quenched and tempered U2 steel. All tests were conducted under force/torque control because macroscopic plastic strains were insignificant in the life range of interest (from 10⁴ to 2 × 10⁶ loading cycles). Stress‐based versions of the Fatemi‐Socie critical plane parameter and of the Smith‐Watson‐Topper parameter with a critical plane interpretation were evaluated using the experimental data. The Smith‐Watson‐Topper parameter was not able to correlate the test data. The Fatemi‐Socie method correlated most of the test data within factor‐of‐three boundaries. A modified Crossland invariant‐based parameter made of two interaction rules between the shear stress amplitude and the maximum hydrostatic stress, and of a definition of shear stress amplitude based on the maximum prismatic hull method, yielded fatigue life estimates in reasonable agreement with the experimental observations.     

Protection of normal cells from irradiation bystander effects by silica-flufenamic acid nanoparticles

The development of a myriad of nanoparticles types has opened new possibilities for the diagnostics and treatment of many diseases, especially for cancer. However, most of the researches done so far do not focus on the protection of normal cells surrounding a tumor from irradiation bystander effects that might lead to cancer recurrence. Gap-junctions are known to be involved in this process, which leads to genomic instability of neighboring normal cells, and flufenamic acid (FFA) is included in a new group of gap-junction blockers recently discovered. The present work explores the use of mesoporous silica nanoparticles MCM-41 functionalized with 3-Aminopropyltriethoxysilane (APTES) for anchoring the flufenamic acid for its prolonged and controlled release and protection from radiation bystander effects. MCM-41 and functionalized samples were structurally and chemically characterized with multiple techniques. The biocompatibility of all samples was tested in a live/dead assay performed in cultured MRC-5 and HeLa cells. HeLa cells cultured were exposed to 50?Gy of gamma-rays and the media transferred to fibroblast cells cultured separately. Our results show that MCM-41 and functionalized samples have high biocompatibility with MCR-5 and HeLa cells, and most importantly, the FFA delivered by these NPs was able to halt apoptosis, one of main bystander effects.     

A novel pH-responsive hydrogel-based on calcium alginate engineered by the previous formation of polyelectrolyte complexes (PECs) intended to vaginal administration

This work aimed to develop a calcium alginate hydrogel as a pH responsive delivery system for polymyxin B (PMX) sustained-release through the vaginal route. Two samples of sodium alginate from different suppliers were characterized. The molecular weight and M/G ratio determined were, approximately, 107?KDa and 1.93 for alginate_S and 32?KDa and 1.36 for alginate_V. Polymer rheological investigations were further performed through the preparation of hydrogels. Alginate_V was selected for subsequent incorporation of PMX due to the acquisition of pseudoplastic viscous system able to acquiring a differential structure in simulated vaginal microenvironment (pH 4.5). The PMX-loaded hydrogel (hydrogel_PMX) was engineered based on polyelectrolyte complexes (PECs) formation between alginate and PMX followed by crosslinking with calcium chloride. This system exhibited a morphology with variable pore sizes, ranging from 100 to 200?μm and adequate syringeability. The hydrogel liquid uptake ability in an acid environment was minimized by the previous PECs formation. In vitro tests evidenced the hydrogels mucoadhesiveness. PMX release was pH-dependent and the system was able to sustain the release up to 6 days. A burst release was observed at pH 7.4 and drug release was driven by an anomalous transport, as determined by the Korsmeyer–Peppas model. At pH 4.5, drug release correlated with Weibull model and drug transport was driven by Fickian diffusion. The calcium alginate hydrogels engineered by the previous formation of PECs showed to be a promising platform for sustained release of cationic drugs through vaginal administration.     

Artificial neural network model for ground vibration amplitudes prediction due to light railway traffic in urban areas

The growth of density and circulation speed of railway transportation systems in urban areas increases the importance of the research issues of the produced environmental impacts. This study presents a field data analysis, obtained during monitoring campaigns of ground vibration, due to light railway traffic in urban areas, based on the artificial neural network (ANN) approach, using quantitative and qualitative predictors. Different ANN-based models, using those predictors, were evaluated/trained and validated. Using several criteria, including those that measures the possibility of ANN overfitting (RR²) and complexity (AIC), the best ANN model was successfully obtained for Lisbon area. This model, with 16 input elements (quantitative and qualitative predictors), 2 neurons on the hidden layer with a hyperbolic tangent sigmoid transfer function, and 1 neuron on the output layer considering a linear transfer function, has 0.9720 for the coefficient of determination and 0.5293 for the sum squared error.

     

Shape preserving design of vibrating structures using topology optimization

In several engineering components, the shape of some functional surfaces needs to be preserved in order to avoid losing performance or even its functionality when subjected to loads. This is particularly important when tight tolerances are required for operational conditions in some regions. If the deformation significantly affects product functionality, it is interesting to use a shape preserving design technique. This will often reduce deformation in a local region. To achieve that, we deal with topology optimization of elastic, continuum structures with Rayleigh damping, subjected to time-harmonic, design-independent external dynamic loading with prescribed excitation frequency, amplitude and spatial distribution. In topology optimization for vibrating structures, the obtained design should often have its resonance frequencies driven far away from the given excitation frequency in order to avoid resonance and to reduce vibration levels. In this work, we explore harmonic vibration problems with the excitation frequency lower than the first resonance frequency of the initial structure. Dynamic compliance minimization is used to improve dynamic response of the structure. An additional local dynamic compliance constraint is used to define the shape preserving problem, thus, reducing deformation in specific regions of a part named shape preserving region (SPR). A commercial FE code (ANSYS^?) is used to solve the finite element problem. The optimization Method of Moving Asymptotes (MMA) is used with the modified Solid Isotropic Material with Penalization (SIMP) material interpolation scheme. The effectiveness of this technique is presented using 2D plane structures. Coherent results were achieved using the proposed optimization formulation. It is possible to observe significant decrease on local deformation, at expense of little increase on global dynamic compliance.     

Essential Oils from Annonaceae Species from Brazil: A Systematic Review of Their Phytochemistry,and Biological Activities

The present work involves a systematic review of the chemical composition and biological effects of essential oils from the Annonaceae species collected in Brazil from 2011 to 2021. Annonaceae is one of the most important botanical families in Brazil, as some species have economic value in the market as local and international fruit. In addition, the species have useful applications in several areas—for instance, as raw materials for use in cosmetics and perfumery and as medicinal plants. In folk medicine, species such as Annona glabra L. and Xylopia sericea A. St.-Hil. are used to treat diseases such as rheumatism and malaria. The species of Annonaceae are an important source of essential oils and are rich in compounds belonging to the classes of mono and sesquiterpenes; of these compounds, α-pinene, β-pinene, limonene, (E)-caryophyllene, bicyclogermacrene, caryophyllene oxide, germacrene D, spathulenol, and β-elemene are the most abundant. The antimicrobial, anti-inflammatory, antileishmania, antioxidant, antiproliferative, cytotoxic, larvicidal, trypanocidal, and antimalarial activities of essential oils from the Annonaceae species in Brazil have been described in previous research, with the most studies on this topic being related to their antiproliferative or cytotoxic activities. In some studies, it was observed that the biological activity reported for these essential oils was superior to that of drugs available on the market, as is the case of the essential oil of the species Guatteria punctata (Aubl.) R. A. Howard., which showed a trypanocidal effect that was 34 times stronger than that of the reference drug benznidazol.     

Piperacillin/tazobactam‐induced neurotoxicity in a hemodialysis patient: A case report

Antibiotics are potentially a cause of neurotoxicity in dialysis patients, the most common are the beta‐lactams as ceftazidime and cefepime, and few cases have been reported after piperacillin/tazobactam use. This report presents a case of a hypertensive and diabetic 67‐year‐old woman in regular hemodialysis, which previously had a stroke. She was hospitalized presenting pneumonia, which was initially treated with cefepime. Two days after treatment, she presented dysarthria, left hemiparesis, ataxia, and IX and X cranial nerves paresis. Computed tomography showed no acute lesions and cefepime neurotoxicity was hypothesized, and the antibiotic was replaced by piperacillin/tazobactam. The neurologic signs disappeared; however, 4 days after with piperacillin/tazobactam treatment, the neurological manifestations returned. A new computed tomography showed no new lesions, and the second antibiotic regimen withdrawn. After two hemodialysis sessions, the patient completely recovered from neurological manifestations. The patient presented sequentially neurotoxicity caused by two beta‐lactams antibiotics. This report meant to alert clinicians that these antibiotics have dangerous neurological effects in chronic kidney disease patients.     

Physical examination of arteriovenous fistula: The influence of professional experience in the detection of complications

Vascular access is one of the leading causes of mobilization of financial resources in health systems for people with chronic kidney disease on hemodialysis. Physical examination of the arteriovenous fistula (AVF) has demonstrated its effectiveness in identifying complications. We decided to evaluate the influence of nurses' professional experience in the detection of complications of the AVF (venous stenosis and steal syndrome). The study took place in eight hemodialysis centers between May and September of 2011 in the north of Portugal. Sample was constituted by registered nurses. The nurses involved in the experiment were divided in two groups: those who had more than 5 years of experience and those who had less than 5 years of experience. Ninety‐two nurses participated in the study: 34 nurses had less than 5 years of professional experience and 58 had more than 5 years of professional experience. In the practices considered by nurses in the detection of venous stenosis, there were no differences observed between the groups (P > 0.05). In steal syndrome, there were no differences observed between the groups in the practices of the nurses in the detection of this complication of the AVF (P > 0.05). We concluded that professional experience does not influence the detection of venous stenosis and steal syndrome.