Oxidation of proteins: Basic principles and perspectives for blood proteomics

Protein oxidation mechanisms result in a wide array of modifications, from backbone cleavage or protein crosslinking to more subtle modifications such as side chain oxidations. Protein oxidation occurs as part of normal regulatory processes, as a defence mechanism against oxidative stress, or as a deleterious processes when antioxidant defences are overcome. Because blood is continually exposed to reactive oxygen and nitrogen species, blood proteomics should inherently adopt redox proteomic strategies. In this review, we recall the biochemical basis of protein oxidation, review the proteomic methodologies applied to analyse redox modifications, and highlight some physiological and in vitro responses to oxidative stress of various blood components.     

Evaluation of Crop Models for Simulating and Optimizing Deficit Irrigation Systems in Arid and Semi-arid Countries Under Climate Variability

The variability of fresh water availability in arid and semi-arid countries poses a serious challenge to farmers to cope with when depending on irrigation for crop growing. This has shifted the focus onto improving irrigation management and water productivity (WP) through controlled deficit irrigation (DI). DI can be conceived as a strategy to deal with these challenges but more knowledge on risks and chances of this strategy is urgently needed. The availability of simulation models that can reliably predict crop yield under the influence of soil, atmosphere, irrigation, and agricultural management practices is a prerequisite for deriving reliable and effective deficit irrigation strategies. In this context, this article discusses the performance of the crop models CropWat, PILOTE, Daisy, and APSIM when being part of a stochastic simulation-based approach to improve WP by focusing primarily on the impact of climate variability. The stochastic framework consists of: (i) a weather generator for simulating regional impacts of climate variability; (ii) a tailor-made evolutionary optimization algorithm for optimal irrigation scheduling with limited water supply; and (iii) the above mentioned models for simulating water transport and crop growth in a sound manner. The results present stochastic crop water production functions (SCWPFs) that can be used as basic tools for assessing the impact on the risk for the potential yield due to water stress and climate variability. Example simulations from India, Malawi, France and Oman are presented and the suitability of these crop models to be employed in a framework for optimizing WP is evaluated.     

Low-Latency Elliptic Curve Scalar Multiplication

This paper presents a low-latency algorithm designed for parallel computer architectures to compute the scalar multiplication of elliptic curve points based on approaches from cryptographic side-channel analysis. A graphics processing unit implementation using a standardized elliptic curve over a 224-bit prime field, complying with the new 112-bit security level, computes the scalar multiplication in 1.9?ms on the NVIDIA GTX 500 architecture family. The presented methods and implementation considerations can be applied to any parallel 32-bit architecture.     

User-centred process for the definition of free-hand gestures applied to controlling music playback

Music is a fundamental part of most cultures. Controlling music playback has commonly been used to demonstrate new interaction techniques and algorithms. In particular, controlling music playback has been used to demonstrate and evaluate gesture recognition algorithms. Previous work, however, used gestures that have been defined based on intuition, the developers’ preferences, and the respective algorithm’s capabilities. In this paper we propose a refined process for deriving gestures from constant user feedback. Using this process every result and design decision is validated in the subsequent step of the process. Therefore, comprehensive feedback can be collected from each of the conducted user studies. Along the process we develop a set of free-hand gestures for controlling music playback. The situational context is analysed to shape the usage scenario and derive an initial set of necessary functions. In a successive user study the set of functions is validated and proposals for gestures are collected from participants for each function. Two gesture sets containing static and dynamic gestures are derived and analysed in a comparative evaluation. The comparative evaluation shows the suitability of the identified gestures and allows further refinement. Our results indicate that the proposed process, that includes validation of each design decision, improves the final results. By using the process to identify gestures for controlling music playback we not only show that the refined process can successfully be applied, but we also provide a consistent gesture set that can serve as a realistic benchmark for gesture recognition algorithms.     

Learning to achieve perfect timesharing: Architectural implications of Hazeltine, Teague, and Ivry (2002).

E. Hazeltine, D. Teague, and R. B. Ivry (see record 2002-02997-003) have presented data that have been interpreted as evidence against a central bottleneck. This article describes simulations of their Experiments 1 and 4 in the ACT-R cognitive architecture, which does possess a central bottleneck in production execution. The simulation model is capable of accounting for the emergence of near-perfect timesharing in Experiment 1 and the detailed data on the distribution of response times from Experiment 4. With practice, the central bottleneck in ACT-R will be reduced to a maximum of 50 ms (1 production cycle) and can often be much less, depending on timing of stages and variability in their times. The authors also show, with a mathematical analysis of E. Hazeltine et al.'s Experiment 2, that the expected dual costs for these kinds of highly practiced tasks will be small in many circumstances, often under 10 ms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Bistable C1 ferroelectric liquid crystal device for e-paper application

Recent progress in both low pretilt and high pretilt defect-free C1 surface stabilized ferroelectric liquid crystal (SSFLC) devices for e-paper application is reviewed. First, by using numerical calculation to investigate the balance between surface azimuthal anchoring energy and bulk elastic energy within the confined chevron layer geometry of C1 and C2, we found it is possible to achieve a zigzag-free C1 state by low azimuthal anchoring alignment with a low pretilt angle. The critical azimuthal anchoring coefficient for defect-free C1 state is calculated. Its relationship with elastic constants, chevron angle, and surface topography effect are also discussed. Second, by using 5° oblique SiO deposition alignment, a defect-free, large memory angle, high contrast ratio, and bistable C1 SSFLC display, which has potential for electronic paper applications has also been developed. The electro-optical properties and bistability of this device have been investigated. Various aspects of defect control are also discussed.     

Designing on-site: Facilitating participatory contextual architecture with mobile phones

Some movements within modern architecture particularly emphasise the importance of matching buildings to their surroundings. However, practicing such “contextual architecture” is highly challenging and typically not something the future inhabitants of a building are well equipped for participating in. This paper explores the potentials of using mobile phone technology for facilitating such client participation in the parts of an architecture process that take place on the building site. For this we introduce ArchiLens, a mobile system for interactive on-site 3D visualisation of houses, and findings from a field study with 40 participants in the process of building or modifying their home. The study showed that using the system helped evoke people’s imagination of the look and feel of their future house, and envision it in context. This enabled them to participate more closely in the design process on-site by iteratively reviewing design alternatives and exploring, for example, other placements and materials.     

Lateral Magnetic Near‐Field Imaging of Plasmonic Nanoantennas With Increasing Complexity

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near‐field interactions between their building blocks. While the electric field distributions and, respectively, the electric interactions of different nanostructures can be routinely measured, for example, by scattering near‐field microscopy, only recently experimental methods for imaging the magnetic field distributions became available. In this paper, we provide direct experimental maps of the lateral magnetic near‐field distributions of variously shaped plasmonic nanoantennas by using hollow‐pyramid aperture scanning near‐field optical microscopy (SNOM). We study both simple plasmonic nanoresonators, such as bars, disks, rings and more complex antennas. For the studied structures, the magnetic near‐field distributions of the complex resonators have been found to be a superposition of the magnetic near‐fields of the individual constituting elements. These experimental results, explained and validated by numerical simulations, open new possibilities for engineering and characterization of complex plasmonic antennas with increased functionality.