Modulation of Aβ42 Aggregation Kinetics and Pathway by Low-Molecular-Weight Inhibitors

The aggregation of amyloid-β 42 (Aβ42) is directly related to the pathogenesis of Alzheimer's disease. Here, we have investigated the early stages of the aggregation process, during which most of the cytotoxic species are formed. Aβ42 aggregation kinetics, characterized by the quantification of Aβ42 monomer consumption, were tracked by real-time solution NMR spectroscopy (RT-NMR) allowing the impact that low-molecular-weight (LMW) inhibitors and modulators exert on the aggregation process to be analysed. Distinct differences in the Aβ42 kinetic profiles were apparent and were further investigated kinetically and structurally by using thioflavin T (ThT) and transmission electron microscopy (TEM), respectively. LMW inhibitors were shown to have a differential impact on early-state aggregation. Insight provided here could direct future therapeutic design based on kinetic profiling of the process of fibril formation.     

Adsorption of Positively-Charged β-Lactoglobulin Derivatives to Casein Micelles

Positively-charged β-lactoglobulin derivatives prepared by amidation or esterification of available carboxyl groups of the native protein were bound strongly by casein micelles. Increasing amounts of these additives progressively decreased rennet coagulation time of casein micelles. Higher concentrations of positively-charged proteins coagulated casein micelles without addition of rennet extract. Of the modified proteins tested, approximately 1.0 g amidated β-lactoglobulin, 2.0 g ethyl-esterified β-lactoglobulin, or 1.0 g methyl-esterified β-lactoglobulin would be required to coagulate 100 ml of casein micelles at concentrations in milk.     

On multiobjective combinatorial optimization and dynamic interim hedging of efficient portfolios

A dynamic portfolio policy is one that periodically rebalances an optimally diversified portfolio to account for time‐varying correlations. In order to sustain target‐level Sharpe performance ratios between rebalancing points, the efficient portfolio must be hedged with an optimal number of contingent claim contracts. This research presents a mixed‐integer nonlinear goal program (MINLGP) that is directed to solve the hierarchical multiple goal portfolio optimization model when the decision maker is faced with a binary hedging decision between portfolio rebalance periods. The MINLGP applied to this problem is formed by extending the separable programming foundation of a lexicographic nonlinear goal program (NLGP) to include branch‐and‐bound constraints. We establish the economic efficiency of applying this normative approach to dynamic portfolio rebalancing by comparing the risk‐adjusted performance measures of a hedged optimal portfolio to those of a naively diversified portfolio. We find that a hedged equally weighted small portfolio and a hedged efficiently diversified small portfolio perform similarly when comparing risk‐adjusted return metrics. However, when percentile risk measures are used to measure performance, the hedged optimally diversified portfolio clearly produces less expected catastrophic loss than does its nonhedged and naively diversified counterpart.     

Casting process and comparison of the properties of adapted load-sensitive magnesium alloys

Magnetic magnesium alloys can be utilized as a load sensitive material, in which the inverse magnetostrictive effect is used in order to measure the actual loads in structural components manufactured from such lightweight sensor alloys. To achieve a material which exhibits magnetic properties, Mg is alloyed with ferromagnetic materials like cobalt or samarium-cobalt. Alloying elements commonly used with Mg are utilized to improve the mechanical properties of these alloys, which however may have a slight negative impact on the magnetic sensitivity. In this work, two separate magnetic Mg alloys are compared, each with properties matched to the opposing requirements: (a) high load sensitivity and (b) satisfactory mechanical properties, respectively. The precipitation behavior of the ferromagnetic constituent Co in Mg together with other alloying elements is shown on the basis of SEM images. In addition, the dissolving behavior of the Co powder during the casting process of a binary Mg–Co alloy is investigated. Cyclic loading tests employing harmonic analyses of eddy current signals are utilized in order to verify the alloys’ sensory properties. The mechanical properties are investigated using tensile tests.     

Psychological services to Spanish-speaking populations: A model curriculum for training competent professionals.

The competent delivery of mental health services to Spanish-speaking clients requires knowledge of Latino cultures, racial and ethnic identity development, variables that impact service delivery, and the Spanish language. We present the Psychological Services for Spanish Speaking Populations (PSSSP) program as a model for training mental health professionals to deliver services to Spanish-speaking clients. The goals for the program were to improve participants' oral and written Spanish language proficiency in work-related contexts and to improve multicultural competence in service delivery to Latino clients. Recommendations for those who wish to offer similar programs include (a) grouping trainees according to Spanish language proficiency, (b) using Spanish language instructors with expertise in teaching heritage language learners, and (c) developing criterion references or measures to assess program outcomes. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Route instructions in map-based human–human and human–computer dialogue: A comparative analysis

When conveying information about spatial situations and goals, speakers adapt flexibly to their addressee in order to reach the communicative goal efficiently and effortlessly. Our aim is to equip a dialogue system with the abilities required for such a natural, adaptive dialogue. In this paper we investigate the strategies people use to convey route information in relation to a map by presenting two parallel studies involving human–human and human–computer interaction. We compare the instructions given to a human interaction partner with those given to a dialogue system which reacts by basic verbal responses and dynamic visualization of the route in the map. The language produced by human route givers is analyzed with respect to a range of communicative as well as cognitively crucial features, particularly perspective choice and references to locations across levels of granularity. Results reveal that speakers produce systematically different instructions with respect to these features, depending on the nature of the interaction partner, human or dialogue system. Our further analysis of clarification and reference resolution strategies produced by human route followers provides insights into dialogue strategies that future systems should be equipped with.     

Comparison of two methods for extraction of volatiles from marine PL emulsions

The dynamic headspace (DHS) thermal desorption principle using Tenax GR tube, as well as the solid phase micro‐extraction (SPME) tool with carboxen/polydimethylsiloxane 50/30 µm CAR/PDMS SPME fiber, both coupled to GC/MS were implemented for the isolation and identification of both lipid and Strecker derived volatiles in marine phospholipids (PL) emulsions. Comparison of volatile extraction efficiency was made between the methods. For marine PL emulsions with a highly complex composition of volatiles headspace, a fiber saturation problem was encountered when using CAR/PDMS‐SPME for volatiles analysis. However, the CAR/PDMS‐SPME technique was efficient for lipid oxidation analysis in emulsions of less complex headspace. The SPME method extracted volatiles of lower molecular weights more efficient than the DHS method. On the other hand, DHS Tenax GR appeared to be more efficient in extracting volatiles of higher molecular weights and it provided a broader volatile spectrum for marine PL emulsion than the CAR/PDMS‐SPME method.     

Dynamic colorimetric properties of mixed thermochromic printing inks

Leuco dye‐based thermochromic inks reversibly change from the coloured to the discoloured state in a defined, comparatively wide temperature region. Inside this region, the colour of a sample depends on the temperature and thermal history, which is known as the hysteresis effect. The colour of such a sample as a function of temperature has the shape of a hysteresis loop. Commercially available thermochromic inks have different loops, narrow or broad, and their shapes range from approximately symmetric to highly asymmetric. These properties are also important in mixtures of inks. The hysteresis loop of a mixture reveals its binary nature if the individual pure inks have well‐separated hysteresis. When inks with close‐separated loops, i.e. with similar activation temperatures, are mixed together, the loop of the mixture fuses together into an apparently single loop. Our research shows that some of their dynamic colour properties could be predicted in advance. However, optic and colorimetric properties of mixtures are not additive.     

Heat of Wetting the Surface of Very Fine Particles of Iron and Its Composites with Ag,Pt, Au,Cu, and Zn with Water

The heat of wetting for very fine iron powder and its composites with Ag, Pt, Au, Cu, and Zn prepared by a thermochemical method is measured. It is established that their surface is hydrophilic. This makes it possible to modify the surface of powders with different substances and create new materials intended for medicine and technics.

     

美国塑料再生需跟上世界步伐

最近从洛杉矶迁居东京的一位朋友几天前打电话给我，说她对新居住地的塑料回收规定甚感惊讶。