Designing conversational agents: effect of conversational form on our comprehension

We have developed a broadcasting agent system, public opinion channel (POC) caster, which generates understandable conversational form from text-based documents. The POC caster circulates the opinions of community members by using conversational form in a broadcasting system on the Internet. We evaluated its transformation rules in two experiments. In experiment 1, we examined our transformation rules for conversational form in relation to sentence length. Twenty-four participants listened to two types of sentence (long sentences and short sentences) with conversational form or with single speech. In experiment 2, we investigated the relationship between conversational form and the user’s knowledge level. Forty-two participants (21 with a high knowledge level and 21 with a low knowledge level) were selected for a knowledge task and listened to two kinds of sentence (sentences about a well-known topic or sentences about an unfamiliar topic). Our results indicate that the conversational form aided comprehension, especially for long sentences and when users had little knowledge about the topic. We explore possible explanations and implications of these results with regard to human cognition and text comprehension.     

Synthesis and Superconducting Properties of Layered Ruthenocuprates

Superconducting properties of layered ruthenocuprates, RuSr ₂ RECu ₂ O ₈ and RuSr ₂ (RE _1-x Ce _x ) ₂ Cu ₂ O ₁₀ (RE = Sm, Eu, Gd), are investigated. The differences between superconductivity of these two phases are considered to be due to, their structural differences ; The RE/Sr substitution is more feasible in RuSr ₂ RECu ₂ O ₈ than in RuSr ₂ (RE _1-x Ce _x ) ₂ Cu ₂ O ₁₀ , while the latter phase shows larger oxygen nonstoichiometry. The superconducting RuSr ₂ Eu ₂ Cu ₂ O ₈ (T _{c, onset} = 25K, T _{c, zero} = 7K) phase was successfully synthesized for the first time, and coexistence of superconductivity and ferromagnetism in these systems was reconfirmed by using single-phase samples.     

Catalytic activity of PdO/ZrO2 catalyst for methane combustion

Catalytic activity of ZrO₂ supported PdO catalysts for methane combustion has been investigated in comparison with Al₂O₃ supported PdO catalysts. It was found that the drop of catalytic activity owing to decomposition of PdO at a high temperature region (600–900°C) was suppressed by using ZrO₂ support. Temperature-programmed reduction (TPR) measurements of the catalyst with hydrogen revealed that the PdO of PdO/Al₂O₃ catalyst was reduced at the temperature less than 100°C, whereas in PdO/ZrO₂ catalyst the consumption of hydrogen was also observed at 200–300°C. This result indicates that the stable PdO species were present in the PdO/ZrO₂ catalyst. In order to confirm the formation of the solid solution of PdO and ZrO₂, X-ray diffraction (XRD) analyses of the mixtures of ZrO₂ and PdO calcined at 700–900°C in air were carried out. The lattice volume of ZrO₂ in the mixture was larger than that of ZrO₂. Furthermore, the Pd thin film on ZrO₂ substrate was prepared as a model catalyst and the depth profile of the elements in the Pd thin film was measured by Auger electron spectroscopy (AES). It was confirmed that Zr and O as well as Pd were present in the Pd thin film heated at 900°C in air. It was considered that the PdO on ZrO₂ support might be stabilized by the formation of the solid solution of PdO and ZrO₂.     

Targeting Cytokines,Pathogen-Associated Molecular Patterns,and Damage-Associated Molecular Patterns in Sepsis via Blood Purification

Sepsis is characterized by a dysregulated immune response to infections that causes life-threatening organ dysfunction and even death. When infections occur, bacterial cell wall components (endotoxin or lipopolysaccharide), known as pathogen-associated molecular patterns, bind to pattern recognition receptors, such as toll-like receptors, to initiate an inflammatory response for pathogen elimination. However, strong activation of the immune system leads to cellular dysfunction and ultimately organ failure. Damage-associated molecular patterns (DAMPs), which are released by injured host cells, are well-recognized triggers that result in the elevation of inflammatory cytokine levels. A cytokine storm is thus amplified and sustained in this vicious cycle. Interestingly, during sepsis, neutrophils transition from powerful antimicrobial protectors into dangerous mediators of tissue injury and organ dysfunction. Thus, the concept of blood purification has evolved to include inflammatory cells and mediators. In this review, we summarize recent advances in knowledge regarding the role of lipopolysaccharides, cytokines, DAMPs, and neutrophils in the pathogenesis of sepsis. Additionally, we discuss the potential of blood purification, especially the adsorption technology, for removing immune cells and molecular mediators, thereby serving as a therapeutic strategy against sepsis. Finally, we describe the concept of our immune-modulating blood purification system.     

The effect of laser texturing of SiC surface on the critical load for the transition of water lubrication mode from hydrodynamic to mixed

Experiments were carried out to verify if the low friction range of SiC in water lubrication can be expanded by micro-pores on the contact surface. Pores were formed by laser, with a diameter of 150 μm and a depth of about 8–10 μm and were distributed in a square array on the contact surface. Seven kinds of textured specimens with different intervals between the pores were tested and compared with the untextured specimen. The effect of the pore area ratio on friction coefficient and the critical load for the transition from hydrodynamic lubrication to mixed lubrication was reported and discussed.     

Wavelength-selective coupling between vertically integratedthin-film waveguides via supermode by a pair of grating couplers

Grating coupling between vertically integrated waveguides via supermode was discussed and demonstrated. Two thin-film waveguides with grating couplers were stacked on a substrate. A guided wave in one waveguide is converted by a grating coupler to a supermode propagating contradirectionally, and then converted by another grating coupler to a guided wave in the other waveguide. The coupling shows high wavelength selectivity, and the wavelength-division add/drop multiplexing function can be combined. A demonstrator was designed and fabricated. Theoretically predicted coupling efficiency was almost 100% with wavelength selectivity of 2 nm, while the experimentally obtained value was 40% in the efficiency and 1 nm in the selectivity     

Effects of processing and cooking on the levels of pesticide residues in wheat samples

The effects of processing and cooking on the levels of pesticide residues in wheat samples were investigated for 13 pesticides in pre-harvest (Pre, 9 pesticides) and post-harvest (Post, 6 pesticides) samples. In the milling process, the transfer ratios (%, total pesticide residue amount in product/that in wheat grain) of wheat bran were greater than 70% and 80% for pre-harvest and post-harvest samples, respectively. The transfer ratios of flour ranged from 1.7% to 23% (Pre) and 4.0% to 11% (Post). There was no significant difference in transfer ratio among the pesticides investigated. The processing factors (Pf, the concentration (mg/kg) of pesticide in product/that in the wheat grain) of flour ranged from 0.030 to 0.40 (Pre) and 0.069 to 0.18 (Post). The values in pre-harvest samples were higher than those in post-harvest samples. Investigation of changes of pesticide residues during processing and/or cooking is useful not only to establish MRLs, but also to recognize actual levels of pesticide residues in food.     

Effects of processing and cooking on the levels of pesticide residues in rice samples

The effects of processing and cooking on the levels of pesticide residues in rice samples were investigated for 11 pesticides in pre-harvest (9 pesticides) and post-harvest (4 pesticides) samples. In the polishing process, the transfer ratio (%, total pesticide residue amount in product/that in brown rice) of rice bran ranged from 40% to 106%, and the transfer ratio of polished rice ranged from 9% to 65% in pre-harvest samples. These values varied from pesticide to pesticide. The processing factor (the concentration (mg/kg) of pesticide in product/that in the brown rice) of polished rice ranged from 0.11 to 0.73. The loss of pesticides during processing and/or cooking did not correlate to any single physical or chemical property. Investigation of changes of pesticide residues during processing and/or cooking is useful not only to establish MRLs, but also to recognize actual levels of pesticide residues in food.     

Hepatic differentiation of mouse embryonic stem cells in a three-dimensional culture system using polyurethane foam

Embryonic stem (ES) cells are a type of pluripotent stem cell line isolated from the inner cell mass of blastocysts and characterized by an almost unlimited self-renewal capacity and differentiation potential in vitro into multiple cell lineages. Therefore the use of ES cells has recently received much attention as a novel cell source for various hybrid artificial organs. To use ES cells, it is necessary to be able to produce functional matured cells from ES cells in large quantities. In this study, we applied polyurethane foam (PUF)/spheroid culture, which enables spontaneous spheroid formation and mass cultivation of cultured cells, to mouse ES cells for hepatic differentiation. Mouse ES cells spontaneously formed spherical multicellular aggregates (spheroids) in the pores of the PUF within 1 d. To induce hepatic differentiation, specific growth factors were added to the culture medium. Mouse ES cells proliferated by day 20, and high cell density (about 1.0 x 10(8) cells/cm(3)-PUF) was achieved. Differentiating ES cells expressed endodermal-specific genes, such as alpha-fetoprotein, albumin and tryptophan 2,3-dioxygenase. The activity of ammonia removal of mouse ES cells per unit volume of the module was detected by day 21 and increased with culture time. Maximum expression levels were comparable to those of primary mouse hepatocytes. Mouse ES cells could express liver-specific functions at high level because of the high cell density culture and hepatic differentiation. These results suggest that the PUF/spheroid culture method could be useful to develop mass differentiation cultures.