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31.
The classical Duhem model provides a finite-dimensional differential model of hysteresis. In this paper, we consider rate-independent and rate-dependent semilinear Duhem models with provable properties. The vector field is given by the product of a function of the input rate and linear dynamics. If the input rate function is positively homogeneous, then the resulting input-output map of the model is rate independent, yielding persistent nontrivial input-output closed curve (that is, hysteresis) at arbitrarily low input frequency. If the input rate function is not positively homogeneous, the input-output map is rate dependent and can be approximated by a rate-independent model for low frequency inputs. Sufficient conditions for convergence to a limiting input-output map are developed for rate-independent and rate-dependent models. Finally, the reversal behavior and orientation of the rate-independent model are discussed. 相似文献
32.
Fuzzy clustering has played an important role in solving many problems. In this paper, we design an unsupervised neural network model based on a fuzzy objective function, called OFUNN. The learning rule for the OFUNN model is a result of the formal derivation by the gradient descent method of a fuzzy objective function. The performance of the cluster analysis algorithm is often evaluated by counting the number of crisp clustering errors. However, the number of clustering errors alone is not a reliable and consistent measure for the performance of clustering, especially in the case of input data with fuzzy boundaries. We introduce two measures to evaluate the performance of the fuzzy clustering algorithm. The clustering results on three data sets, Iris data and two artificial data sets, are analyzed using the proposed measures. They show that OFUNN is very competitive in terms of speed and accuracy compared to the fuzzy c-means algorithm. 相似文献
33.
Verrucous carcinoma is a variant of squamous cell carcinoma and should be distinguished from benign papilloma and well-differentiated nonverrucous squamous cell carcinoma. It is rare tumor of the sinonasal tract. Occasionally, conventional squamous cell carcinomatous components may be seen in verrucous carcinoma. This entity is called a hybrid verrucous squamous cell carcinoma. We report a case of hybrid verrucous squamous cell carcinoma occurring in the nasal cavity and paranasal sinus of a 67-year-old male. The removed mass shows the typical feature of verrucous carcinoma, but focally conventional squamous cell carcinomatous area is also noted. The treatment of this case follows verrucous carcinoma, but close follow up is mandatory because it may potentially spread to regional lymph nodes in contrast to pure form of verrucous carcinoma. 相似文献
34.
Microsystem Technologies - In this research we present an algorithm for a six-wheeled robotic vehicle with articulated suspension (RVAS) to estimate the vehicle velocity and acceleration states,... 相似文献
35.
Park Jimin Kim Youngjin Kim Hyeongrae Kim JuYeon Oh Dongho 《Microsystem Technologies》2021,27(6):2515-2522
Microsystem Technologies - Printed electronics such as solar cells, RFIDs, and display panels can be made using printed electronic technology by printing viscous liquids having various properties... 相似文献
36.
Dinesh Kalyanasundaram Shinnosuke Inoue Jong-Hoon Kim Hyun-Boo Lee Zenko Kawabata Woon-Hong Yeo Gerard A. Cangelosi Kieseok Oh Dayong Gao Kyong-Hoon Lee Jae-Hyun Chung 《Microfluidics and nanofluidics》2012,13(2):217-225
Simple, high-yield concentration of DNA is important for high-throughput genetic analysis and disease diagnosis. Glass-based microfilters are popular but the process requires centrifugation steps with cumbersome chemical processes. As an alternative, a concentration method using an electric field has been explored previously, but with limited efficiency. In this paper, electric field-induced concentration and capture of DNA are studied by using high-aspect-ratio microtips coated with a gold layer. The microtips are immersed longitudinally into a solution of 100???L containing ??-phage DNA. After DNA concentration using an electric field, the microtips are withdrawn from the solution. Under AC- and biased AC fields, DNA is concentrated by electrophoresis (EP), dielectrophoresis (DEP), and electroosmotic flow (EOF). To reduce capillary effects in the withdrawal process, the microtips are coated with positively charged poly-l-lysine (PLL). The pattern of captured DNA is analyzed by fluorescence microscopy. DEP attracts DNA molecules at the edges of microtips, where the highest gradient of electric field exists. EP attracts DNA onto the surface of microtips following the vectors of an electric field. EOF generates vortexes that deliver DNA onto microtips. Using this method, 85% of DNA is captured on the PLL-coated microtips after three sequential captures. The concentration mechanism can potentially facilitate rapid and simple preparation of DNA for downstream analysis. 相似文献
37.
The infiltration behaviour of a tin melt, as an internal electrode, to the porous layers, and the electrical properties of multilayer ceramic capacitors was investigated by electrode infiltration. By preventing green-state delamination between the dielectric green sheet and the carbon paste, uniform porous layers, 5 m thick, could be formed after sintering. When 15 vol % ceramic pillars were added to the carbon paste, the porous layer of the sintered samples could be considered as a porous solid formed by many pores larger than 4 m. The critical pressure for the infiltration of tin melt into such a porous layer was found to be 0.5 MPa. With a high infiltration pressure, the resistivity of multilayer capacitors was decreased to 108–109cm due to the growth of micro-defects formed on the surface of the dielectric layers during the lamination process. 相似文献
38.
Dielectric properties and microstructural behaviour of B-site calcium-doped barium titanate ceramics 总被引:1,自引:0,他引:1
Dielectric properties and microstructural behaviour of Ba1–x
Sr
x
Ti1–y
Ca
y
O3–y
ceramics, where strontium and calcium were doped on the barium and titanium sites, respectively, within the range 0x0.24 and 0y0.05, were investigated. Calcium addition decreased the tetragonality,c/a, increased the unit cell volume, and lowered the Curie temperature, which were all attributed to the occupancy of Ca2+ ions on titanium sites. When sintered at a low oxygen partial pressure of 10–9 MPa, a resistivity higher than 1011 cm was maintained for the formulations containing B-site calcium substitution more than 0.5 mol %. With increasing the amount of calcium addition, the Curie peak was depressed and completely broadened for the compositions with calcium addition more than 3 mol %, where the average grain size was smaller than 1 m. Co-firing with nickel electrodes in a reducing atmosphere also depressed the Curie peak and inhibited the grain growth due to the diffusion of nickel into the dielectrics. 相似文献
39.
Jang Mi Han Jae Kyung Sohng Woo-Haeng Lee Tae-Jin Oh Hye Jin Jung 《International journal of molecular sciences》2021,22(5)
We recently discovered a novel nargenicin A1 analog, 23-demethyl 8,13-deoxynargenicin (compound 9), with potential anti-cancer and anti-angiogenic activities against human gastric adenocarcinoma (AGS) cells. To identify the key molecular targets of compound 9, that are responsible for its biological activities, the changes in proteome expression in AGS cells following compound 9 treatment were analyzed using two-dimensional gel electrophoresis (2-DE), followed by MALDI/TOF/MS. Analyses using chemical proteomics and western blotting revealed that compound 9 treatment significantly suppressed the expression of cyclophilin A (CypA), a member of the immunophilin family. Furthermore, compound 9 downregulated CD147-mediated mitogen-activated protein kinase (MAPK) signaling pathway, including c-Jun N-terminal kinase (JNK) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) by inhibiting the expression of CD147, the cellular receptor of CypA. Notably, the responses of AGS cells to CypA knockdown were significantly correlated with the anticancer and antiangiogenic effects of compound 9. CypA siRNAs reduced the expression of CD147 and phosphorylation of JNK and ERK1/2. In addition, the suppressive effects of CypA siRNAs on proliferation, migration, invasion, and angiogenesis induction of AGS cells were associated with G2/M cell cycle arrest, caspase-mediated apoptosis, inhibition of MMP-9 and MMP-2 expression, inactivation of PI3K/AKT/mTOR pathway, and inhibition of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression. The specific interaction between compound 9 and CypA was also confirmed using the drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA) approaches. Moreover, in silico docking analysis revealed that the structure of compound 9 was a good fit for the cyclosporin A binding cavity of CypA. Collectively, these findings provide a novel molecular basis for compound 9-mediated suppression of gastric cancer progression through the targeting of CypA. 相似文献
40.
Namhun Lee Se-Jong Oh Jang-Woo Park Kyung-Rok Nam Kyung-Jun Kang Kyo-Chul Lee Yong-Jin Lee June-Seek Choi Jeong-Ho Seok Jae-Yong Choi 《International journal of molecular sciences》2021,22(5)
Early life stress (ELS) is strongly associated with psychiatric disorders such as anxiety, depression, and schizophrenia in adulthood. To date, biological, behavioral, and structural aspects of ELS have been studied extensively, but their functional effects remain unclear. Here, we examined NeuroPET studies of dopaminergic, glutamatergic, and serotonergic systems in ELS animal models. Maternal separation and restraint stress were used to generate single or complex developmental trauma. Body weights of animals exposed to single trauma were similar to those of control animals; however, animals exposed to complex trauma exhibited loss of body weight when compared to controls. In behavioral tests, the complex developmental trauma group exhibited a decrease in time spent in the open arm of the elevated plus-maze and an increase in immobility time in the forced swim test when compared to control animals. In NeuroPET studies, the complex trauma group displayed a reduction in brain uptake values when compared to single trauma and control groups. Of neurotransmitter systems analyzed, the rate of decrease in brain uptake was the highest in the serotonergic group. Collectively, our results indicate that developmental trauma events induce behavioral deficits, including anxiety- and depressive-like phenotypes and dysfunction in neurotransmitter systems. 相似文献