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排序方式: 共有2717条查询结果,搜索用时 15 毫秒
21.
Y Bergeron N Ouellet AM Deslauriers M Simard M Olivier MG Bergeron 《Canadian Metallurgical Quarterly》1998,42(10):2527-2533
It has recently become apparent that overwhelming inflammatory reactions contribute to the high mortality rate associated with pneumococcal infection in immunocompetent hosts. Cefodizime (CEF) is an antibiotic that seems to be endowed with immunomodulating properties. To investigate the influence of CEF on the pulmonary inflammatory response induced by Streptococcus pneumoniae, we infected mice with repeated intranasal inoculations of 10(7) CFU of heat-killed fluorescein isothiocyanate-labeled bacteria, which are insensitive to the killing properties of the drug. CEF downregulated but did not abolish the strong polymorphonuclear leukocyte (PMN) recruitment induced by S. pneumoniae. PMN recruitment was not primarily mediated by leukotriene B4 in this model. The drug did not interfere with intrinsic mechanisms of phagocytosis by PMNs and alveolar macrophages. CEF totally abrogated the pneumococcus-induced tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) secretion in bronchoalveolar lavage fluid. The drug also prevented IL-6 release in lung homogenates and partly inhibited TNF-alpha, but it did not interfere with IL-1alpha secretion in the lungs of infected mice. The fractional and selective downregulation of inflammatory cells and cytokines by CEF suggests cell-specific and intracellular specific mechanisms of interaction of the drug. The immunomodulatory properties of CEF may help restrain excessive inflammatory reactions, thus contributing to the reported good clinical efficacy of the drug against lower respiratory tract infections. 相似文献
22.
Using time-driven activity-based costing to manage digital forensic readiness in large organisations
A digital forensic readiness (DFR) programme consists of a number of activities that should be chosen and managed with respect to cost constraints and risk. Traditional cost systems, however, can not provide the cost of individual activities. This makes it difficult or impossible for organisations to consider cost when making decisions about specific activities. In this paper we show that the relatively new cost system, time-driven activity-based costing (TDABC), can be used to determine the cost of implementing and managing activities required for DFR. We show through analysis and simulation that the cost information from a TDABC model can be used for such decisions. We also discuss some of the factors that ought to be considered when implementing or managing the use of TDABC in a large organisation. 相似文献
23.
A theory of self-calibration of a moving camera 总被引:96,自引:15,他引:81
There is a close connection between the calibration of a single camera and the epipolar transformation obtained when the camera undergoes a displacement. The epipolar transformation imposes two algebraic constraints on the camera calibration. If two epipolar transformations, arising from different camera displacements, are available then the compatible camera calibrations are parameterized by an algebraic curve of genus four. The curve can be represented either by a space curve of degree seven contained in the intersection of two cubic surfaces, or by a curve of degree six in the dual of the image plane. The curve in the dual plane has one singular point of order three and three singular points of order two.If three epipolar transformations are available, then two curves of degree six can be obtained in the dual plane such that one of the real intersections of the two yields the correct camera calibration. The two curves have a common singular point of order three.Experimental results are given to demonstrate the feasibility of camera calibration based on the epipolar transformation. The real intersections of the two dual curves are found by locating the zeros of a function defined on the interval [0, 2]. The intersection yielding the correct camera calibration is picked out by referring back to the three epipolar transformations. 相似文献
24.
Abdullah Kayi Olivier Serres Tarek El-Ghazawi 《International journal of parallel programming》2014,42(3):435-455
Chip Multiprocessors (CMPs) have different technological parameters and physical constraints than earlier multi-processor systems, which should be taken into consideration when designing cache coherence protocols. Also, contemporary cache coherence protocols use invalidate schemes that are known to generate a high number of coherence misses. This is especially true under producer-consumer sharing patterns that can become a performance bottleneck as the number of cores increases. This paper presents two mechanisms to design efficient and scalable cache coherence protocols for CMPs. First, we propose an adaptive hybrid protocol to reduce coherence misses observed in write-invalidate based protocols. The proposed protocol is based on a write-invalidate scheme. However, adaptively, it can push updates to potential consumers based on observed producer-consumer sharing patterns. Secondly, we extend this adaptive protocol with an interconnection resource aware mechanism. Experimental evaluations, conducted on a tiled-CMP via full-system simulation, were used to assess the performance from our proposed dynamic hybrid protocols. Performance analysis is presented on a set of scientific applications from the SPLASH-2 and NAS parallel benchmark suites. Results showed that the proposed mechanisms reduce cache-to-cache sharing misses up to 48 % and speed up application performance up to 34 %. In addition, the proposed interconnection resource aware mechanism is proven to perform well under varying interconnection utilizations. 相似文献
25.
Gruffat D De La Torre A Chardigny JM Durand D Loreau O Sébédio JL Bauchart D 《Lipids》2003,38(2):157-163
Hepatic metabolism of the two main isomers of CLA (9cis-11 trans, 10trans-12cisC18∶2) was compared to that of oleic acid (representative of the main plasma FA) in 16 rats by using the in vitro method of incubated liver slices. Liver tissue samples were incubated at 37°C for 17h under an atmosphere of 95% O2/5%CO2 in a medium supplemented with 0.75 mM of FA mixture (representative of circulating nonesterified FA) and with 55 μM [1-14C]9cis-11 trans C18∶2, [1-14C]10trans-12cis C18∶2, or [1-14C]oleate. The uptake of CLA by hepatocytes was similar for both isomers (9%) and was three times higher (P<0.01) than for oleate (2.6%). The rate of CLA isomer oxidation was two times higher (49 and 40% of incorporated amounts of
9cis-11 trans and 10trans-12 cis, respectively) than that of oleate (P<0.01). Total oxidation of oleate and CLA isomers into [14CO2] was low (2 to 7% of total oxidized FA) compared to the partial oxidation (93 to 98%) leading to the production of [14C] acid-soluble products. CLA isoemrs escaping from catabolism were both highly desaturated (26.7 and 26.8%) into conjugated
18∶3. Oleate and CLA isomers were mainly esterified into neutral lipids (30%). They were slowly secreted as parts of VLDL
particles (<0.4% of FA incorporated into cells), the extent of secretion of oleate and of 10trans-12 cis being 2.2-fold higher than that of 9cis-11 trans (P<0.02). In conclusion, this study clearly showed that both CLA isomers were highly catabolized by hepatocytes, reducing their
availability for peripheral tissues. Moreover, more than 25% of CLA escaping from catabolism was converted into conjugated
18∶3, the biological properties of which remain to be elucidated. 相似文献
26.
Olivier Younes 《通讯和计算机》2014,(7):539-542
An incubator is an organization that supports new ventures to grow and survive during the early stages. Mainly dedicated to information technology, life science may appear to be the next hot spot for incubators. Are there stabilized good practices? Are the business models in information technology and in life science comparable when it goes to start-ups' incubation? Leveraging our experience as practitioner in this field and using an inductive methodology, this paper tends to propose simple principles to help build robust incubators in life science, and to contribute to disseminate an entrepreneurial approach through an industry still dominated by blue chips. 相似文献
27.
Olivier Renoult Jean-Pierre Boilot Frédéric Chaput Renée Papiernik Liliane G. Hubert-Pfalzgraf Martine Lejeune 《Journal of the American Ceramic Society》1992,75(12):3337-3340
The sol–gel method has been developed for the preparation of pure Ba(Mg1/3 Ta2/3 )O3 ceramics. This involves the reaction of the heterometallic alkoxide Ta2 Mg(OEt)12 with hydrated barium hydroxide Ba(OH)2 ·8H2 O. Complete crystallization of the sol–gel-derived powder is achieved at 600°C, leading to a cubic perovskite type phase. After sintering at 1400°C (2–5 h), a trigonal cell arises from Mg–Ta ordering (the degree of order is greater than 0.9), and about 98.5% of the theoretical density is obtained. Preliminary microwave dielectric measurements show that the dielectric constant and the unloaded Q u of the ceramics are 24.2 and 6750, respectively, at 7.7 GHz. 相似文献
28.
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30.
Pierre Colomb Alexis Irlande Olivier Raynaud Yoan Renaud 《Annals of Mathematics and Artificial Intelligence》2014,70(1-2):107-122
A collection of sets on a ground set U n (U n ?=?{1,2,...,n}) closed under intersection and containing U n is known as a Moore family. The set of Moore families for a fixed n is in bijection with the set of Moore co-families (union-closed families containing the empty set) denoted ${\mathbb{M}}_n$ . This paper follows the work initiated in Colomb et al. (Ann Math Artif Intell 67(2):109–122, 2013) in which we have given an inductive definition of the lattice of Moore co-families. In the present paper we use this definition to define a recursive decomposition tree of any Moore co-family and we design an original algorithm to compute the closure under union of any family. Then we compare performance of this algorithm to performance of Ganter’s algorithm and Norris’ algorithm. 相似文献