The venotonic drug hydroxyethylrutosiden does not prevent or reduce docetaxel-induced fluid retention: results of a comparative study

PURPOSE: Fluid retention, which includes peripheral edema, ascites, pleural or pericardial effusion, or a combination of these that is sometimes associated with significant weight gain, is one of the most troublesome cumulative side effects of docetaxel. A suggestive observation from the data base available at the manufacturer (Rhone-Poulenc Rorer) was that patients who received venotonic drugs appeared to tolerate more courses of docetaxel. This prompted a comparative study to investigate whether the venotonic drug hydroxyethylrutosiden could reduce or delay docetaxel-related fluid retention. METHODS: A total of 85 patients with metastatic breast cancer who were treated with docetaxel at a dose of 100 mg/m2 with corticoid comedication were allocated to receive either 300 mg hydroxyethylrutosiden given orally four times daily (group A) or no hydroxyethylrutosiden (group B). The end point for analysis was the development of fluid retention of > or = grade 2. RESULTS: Fluid retention of > or = grade 2 was reported in 14 of 42 patients (33%) in group A and in 15 of 43 patients (35%) in group B and occurred after a median of 4 cycles of docetaxel in both groups. Weight gain was similar in groups A and B. CONCLUSION: We conclude that hydroxyethylrutosiden does not reduce or delay the incidence and severity of docetaxel-related fluid retention.     

Microscopic Visualization Technique to Predict the Permeation of Organic Solvents through PVC Pipes in Water Distribution Systems

Organic contaminants may permeate through plastic pipes in water distribution systems and adversely affect the quality of drinking water. In this study, we developed a microscopic visualization technique to investigate the permeation of common organic contaminants (benzene, toluene, ethylbenzene, xylene, and trichloroethene) through polyvinyl chloride (PVC) pipes. By observing the propagation of organic moving fronts in the pipe materials with a light microscope, the technique was able to predict the permeation breakthrough times through PVC pipes that were determined in the pipe-bottle test. The advance of an organic moving front was found to be linearly dependent on the square-root of time and the propagation rate increased with an increase in the external organic chemical activity. Permeation of organic mixtures into PVC pipes was found to be additive in proportion to the permeation rates and volume percents of each component. In combination with a 2-year pipe-bottle test for PVC pipes exposed to premium gasoline, mathematical extrapolations based on the microscopic visualization tests predicted that PVC pipe are likely to resist permeation by commercial gasoline for the service life of the pipe.     

Bone cell attachment and growth on well‐characterized chitosan films

Chitosan has been widely researched for bone tissue and implant applications. While initial results are promising, there are inconsistent reports regarding the biological responses. This may be due to inadequate evaluation of chitosan material properties. This study evaluated normal human osteoblast precursor cell attachment and proliferation on a series of well‐characterized chitosan films. The chitosan films exhibited a range of properties: 76–96% degree of de‐acetylation (DDA), 2400–8200 kDa viscosity‐average molecular weight, 62–90° contact angle, 0.24–2.46% residual ash, 5.3–287 µg cm^?2 residual protein and 23–40% crystallinity. There was no trend or correlation between DDA, crystallinity, contact angle, molecular weight, residual ash or protein content and the attachment or growth of bone cells on chitosan films. All films supported higher levels of bone cell proliferation than tissue culture plastic, which supports the general hypothesis that chitosans are osteocompatible. The 78 and 92% DDA chitosan films supported the most cell proliferation, approximately 16 times that of tissue culture plastic controls, but no chitosan physiochemical property correlated with the increased cell growth. The lack of correlation is hindered since more than one physiochemical property changed for each chitosan material. Data do indicate that there may be much variability in chitosan materials, and this variability may make understanding and comparing biological performance of chitosan materials difficult. These results highlight the need for systematic characterizations of chitosan materials for predictable biomedical applications. Copyright © 2006 Society of Chemical Industry     

Nickel Activated Phosphating of Cold-Rolled Steel

Phosphating of cold-rolled steel was investigated. A dense, uniform and fine-grained zinc phosphate crystalline layer was observed after nickel activation. These crystal-line layers were shown to have improved strength, durability and corrosion resistance. The mechanism of the growth of the zinc phosphate layer is discussed.     

Einflu? der Probenoberfl?che auf den Gasanalysenwert UF-gebundener Spanplatten

Ohne Zusammenfassung     

Modeling visual attention's modulatory aftereffects on visual sensitivity and quality evaluation.

With the fast development of visual noise-shaping related applications (visual compression, error resilience, watermarking, encryption, and display), there is an increasingly significant demand on incorporating perceptual characteristics into these applications for improved performance. In this paper, a very important mechanism of the human brain, visual attention, is introduced for visual sensitivity and visual quality evaluation. Based upon the analysis, a new numerical measure for visual attention's modulatory aftereffects, perceptual quality significance map (PQSM), is proposed. To a certain extent, the PQSM reflects the processing ability of the human brain on local visual contents statistically. The PQSM is generated with the integration of local perceptual stimuli from color contrast, texture contrast, motion, as well as cognitive features (skin color and face in this study). Experimental results with subjective viewing demonstrate the performance improvement on two PQSM-modulated visual sensitivity models and two PQSM-based visual quality metrics.     

Correlation of material properties to reliability performance of anisotropic conductive adhesive flip chip packages

The anisotropic conductive adhesive (ACA) is a promising solder alternative candidate that shows potential for further pitch reduction. Although much work has been published on ACA joint behavior, study on correlation of material properties with reliability performance is still lacking. The main objective in this study was to identify the impact of material properties on reliability, so as to engineer highly reliable microelectronics assemblies. Four representative ACA materials (both film and paste types) with diverse properties were selected. Material properties were characterized as close as possible to "stress test" conditions so as to allow more accurate correlation predictions. Reliability performance was obtained by assembling test chips of 200-/spl mu/m pitch onto BT-substrates, then subjecting them to reliability tests. Correlation analysis was conducted and key material properties that contributed to good reliability performance were identified. Findings indicated that the best properties for high reliability assemblies were: high adhesion strength after subjecting to "stress aging", low coefficient of moisture expansion (CME) and low elastic modulus (E).