Influence of the internal inertia of the building envelope on summertime comfort in buildings with high internal heat loads

The aim of this study was to assess the influence of thermal mass placed on the inner side of the building envelope, described as the dynamic internal areal heat capacity (International Standard ISO 13786), on the summertime thermal comfort in buildings characterised by high internal heat loads.To that aim, simultaneous monitoring was carried out on rooms with high internal heat loads (school classrooms), varying the internal inertia of the envelope through the introduction of an insulating panel on the interior side. Analytical assessment was performed in order to include different inertia values and combinations of both external and internal heat loads.The study allowed the threshold values of internal areal heat capacity to be determined with respect to the different periodic transmittance values of the walls, assessed according to the adaptive thermal comfort model described in Standard EN15251.These values could be adopted in energy saving regulations which, being based on semi-stationary calculation models, tend to consider the performance of building envelopes as analogous even if there is different thermal inertia.     

Influence of Heterogeneous Magnetism on Magneto-Optical Properties

The influence of inhomogeneity on magnetic materials is considered; in particular, we examine how it affects the magneto-optical (MO) response of films and multilayers. From ab initio calculations of the band structure, the optical conductivity tensor is derived, providing the basis for computing the MO spectra. The presence of magnetic nanoprecipitates is taken into account by modeling the system as an effective medium or as an infinitely thin layered structure. A possible depth concentration distribution of the magnetic species is also accounted for, by considering the structure as a sequence of layers. This formalism is applied to some real systems constituted by magnetic particles dispersed in a hosting nonmagnetic matrix. The agreement between theoretical and measured MO Kerr effect spectra supports the validity of the model and establishes its predictive power, suggesting that the analysis of experimental MO spectra can provide information not only on the magnetic, but also on the structural properties of heterogeneous magnetic systems.     

A Novel Genetic Variant in the WFS1 Gene in a Patient with Partial Uniparental Mero-Isodisomy of Chromosome 4

Wolfram syndrome is a rare autosomal recessive disorder characterized by optic atrophy and diabetes mellitus. Wolfram syndrome type 1 (WFS1) is caused by bi-allelic pathogenic variations in the wolframin gene. We described the first case of WFS1 due to a maternal inherited mutation with uniparental mero-isodisomy of chromosome 4. Diabetes mellitus was diagnosed at 11 years of age, with negative anti-beta cells antibodies. Blood glucose control was optimal with low insulin requirement. No pathogenic variations in the most frequent gene causative of maturity-onset diabetes of the young subtypes were detected. At 17.8 years old, a rapid reduction in visual acuity occurred. Genetic testing revealed the novel homozygous variant c.1369A>G; p.Arg457Gly in the exon 8 of wolframin gene. It was detected in a heterozygous state only in the mother while the father showed a wild type sequence. In silico disease causing predictions performed by Polyphen2 classified it as “likely damaging”, while Mutation Tester and Sift suggested it was “polymorphism” and “tolerated”, respectively. High resolution SNP-array analysis was suggestive of segmental uniparental disomy on chromosome 4. In conclusion, to the best of our knowledge, we describe the first patient with partial uniparental mero-isodisomy of chromosome 4 carrying a novel mutation in the wolframin gene. The clinical phenotype observed in the patient and the analysis performed suggest that the genetic variant detected is pathogenetic.     

Experimental study of free convection from a pair of vertical arrays of horizontal cylinders at very low Rayleigh numbers

Steady laminar free convection from a pair of vertical arrays of equally-spaced uniformly heated horizontal cylinders set in free air is studied experimentally. A specifically developed experimental facility is used to perform heat flux and temperature measurements and thermal field visualization by means of Schlieren technique. Experiments are performed for pairs of tube-arrays consisting of five circular cylinders, for center-to-center horizontal and vertical spacing ranging from 2 to 145 cylinder-diameters and from 4 to 12 cylinder-diameters respectively, and for values of the Rayleigh number based on the cylinder-diameter in the range between 2.4 and 11.9. It is found that any cylinder may exhibit either enhanced or reduced Nusselt numbers with respect to the case of single array, depending on its location in the array, on the geometry of the array, as well as on the Rayleigh number. The visualization has allowed to relate a number of observed effects to the fact that side-by-side placement of the arrays produces a lateral air suction into the space between them.     

Prognostic and Theranostic Applications of Positron Emission Tomography for a Personalized Approach to Metastatic Castration-Resistant Prostate Cancer

Metastatic castration-resistant prostate cancer (mCRPC) represents a condition of progressive disease in spite of androgen deprivation therapy (ADT), with a broad spectrum of manifestations ranging from no symptoms to severe debilitation due to bone or visceral metastatization. The management of mCRPC has been profoundly modified by introducing novel therapeutic tools such as antiandrogen drugs (i.e., abiraterone acetate and enzalutamide), immunotherapy through sipuleucel-T, and targeted alpha therapy (TAT). This variety of approaches calls for unmet need of biomarkers suitable for patients’ pre-treatment selection and prognostic stratification. In this scenario, imaging with positron emission computed tomography (PET/CT) presents great and still unexplored potential to detect specific molecular and metabolic signatures, some of whom, such as the prostate specific membrane antigen (PSMA), can also be exploited as therapeutic targets, thus combining diagnosis and therapy in the so-called “theranostic” approach. In this review, we performed a web-based and desktop literature research to investigate the prognostic and theranostic potential of several PET imaging probes, such as ¹⁸F-FDG, ¹⁸F-choline and ⁶⁸Ga-PSMA-11, also covering the emerging tracers still in a pre-clinical phase (e.g., PARP-inhibitors’ analogs and the radioligands binding to gastrin releasing peptide receptors/GRPR), highlighting their potential for defining personalized care pathways in mCRPC.     

Fully non-interactive onion routing with forward secrecy

Onion routing is a privacy-enabling protocol that allows users to establish anonymous channels over a public network. In such a protocol, parties send their messages through $n$ anonymizing servers (called a circuit) using several layers of encryption. Several proposals for onion routing have been published in recent years, and TOR, a real-life implementation, provides an onion routing service to thousands of users over the Internet. This paper puts forward a new onion routing protocol which outperforms TOR by achieving forward secrecy in a fully non-interactive fashion, without requiring any communication from the router and/or the users and the service provider to update time-related keys. We compare this to TOR which requires $O(n^2)$ rounds of interaction to establish a circuit of size $n$ . In terms of the computational effort required to the parties, our protocol is comparable to TOR, but the network latency associated with TOR’s high round complexity ends up dominating the running time. Compared to other recently proposed alternative to TOR, such as the PB-OR (PETS 2007) and CL-OR (CCS 2009) protocols, our scheme still has the advantage of being non-interactive (both PB-OR and CL-OR require some interaction to update time-sensitive information), and achieves similar computational performances. We performed implementation and simulation tests that confirm our theoretical analysis. Additionally, while comparing our scheme to PB-OR, we discovered a flaw in the security of that scheme which we repair in this paper. Our solution is based on the application of forward secure encryption. We design a forward secure encryption scheme (of independent interest) to be used as the main encryption scheme in our onion routing protocol.     

The Paradox Effect of Calcification in Carotid Atherosclerosis: Microcalcification Is Correlated with Plaque Instability

Background: this study aims to investigate the possible association among the histopathologic features of carotid plaque instability, the presence of micro- or macrocalcifications, the expression of in situ inflammatory biomarkers, and the occurrence of the major risk factors in this process in a large series of carotid plaques. Methods: a total of 687 carotid plaques from symptomatic and asymptomatic patients were collected. Histological evaluation was performed to classify the calcium deposits in micro or macrocalcifications according to their morphological features (location and size). Immunohistochemistry was performed to study the expression of the main inflammatory biomarkers. Results: results here reported demonstrated that calcifications are very frequent in carotid plaques, with a significant difference between the presence of micro- and macrocalcifications. Specifically, microcalcifications were significantly associated to high inflamed unstable plaques. Paradoxically, macrocalcifications seem to stabilize the plaque and are associated to a M2 macrophage polarization instead. Discussion: the characterization of mechanisms involved in the formation of carotid calcifications can lay the foundation for developing new strategies for the management of patients affected by carotid atherosclerosis. Data of this study could provide key elements for an exhaustive evaluation of carotid plaque calcifications allowing to establish the risk of associated clinical events.     

Cruise ships like buildings: Wayfinding solutions to improve emergency evacuation

This research aims at demonstrating that wayfinding solutions can improve the effectiveness of the evacuation processes in complex architectural spaces such as those of cruise ships. We investigated the behaviours of passengers in maritime disaster to figure out whether people act similarly during buildings egress and ships evacuation. Data were collected through questionnaires administered in 2015 to passengers boarding various cruise ships at the port of Ancona (Italy), and through the analysis of real footage of the evacuation of the Costa Concordia. The open source software Fire Dynamics Simulator with Evacuation (FDS+EVAC), used in building egress analyses, was adapted to include these behavioural and event information such as familiarity with ship layout, ship rotation and lifeboats boarding. Simulation results on the case study confirmed similarities between ships and buildings evacuations, underlining the effectiveness of wayfinding solutions to improve passengers’ evacuation flows and routes selection. This study also demonstrated that computer simulation could benefit the ship design process, the preparation of safety guidelines, and the crewmembers during naval emergency management training.