Development of a hybrid ECT sensor for JSFR SG double-wall tubes

A new design has been adopted for the steam generator (SG) tubes of the Japan Sodium-cooled Fast Reactor (JSFR) using double-wall tubes. This paper estimates and assesses the effectiveness of detecting defects in SG double-wall tubes of the JSFR by using combined high-frequency eddy current testing (ECT) and low-frequency remote field eddy current sensors. We confirm that the proposed hybrid ECT sensor is highly sensitive to small defects, fatigue cracks, and other defects even when located under support plates of tubes. The parameters of the hybrid ECT sensor are designed and optimized to detect small defects using accurate numerical simulations based on the finite element method, using an in-house developed code. The sensitivity and high performance of the hybrid ECT sensor was validated with experimental measurements.     

Development and characterisation of microporous biomimetic scaffolds loaded with magnetic nanoparticles as bone repairing material

Fine-tuning of the scaffolds structural features for bone tissue engineering can be an efficient approach to regulate the specific response of the osteoblasts. Here, we loaded magnetic nanoparticles aka superparamagnetic iron oxide nanoparticles (SPIONs) into 3D composite scaffolds based on biological macromolecules (chitosan, collagen, hyaluronic acid) and calcium phosphates for potential applications in bone regeneration, using a biomimetic approach. We assessed the effects of organic (chitosan/collagen/hyaluronic acid) and inorganic (calcium phosphates, SPIONs) phase over the final features of the magnetic scaffolds (MS). Mechanical properties, magnetic susceptibility and biological fluids retention are strongly dependent on the final composition of MS and within the recommended range for application in bone regeneration. The MS architecture/pore size can be made bespoken through changes of the final organic/inorganic ratio. The scaffolds undertake mild degradation as the presence of inorganic components hinders the enzyme catalytic activity. In vitro studies indicated that osteoblasts (SaOS-2) on MS9 had similar cell behaviour activity in comparison with the TCP control. In vivo data showed an evident development of integration and resorption of the MS composites with low inflammation activity. Current findings suggest that the combination of SPIONs into 3D composite scaffolds can be a promising toolkit for bone regeneration.     

Defect analysis and excitons diffusion in undoped homoepitaxial diamond films after polishing and oxygen plasma etching

Several 65 μm thick epitaxial diamond films prepared on (100) Ib substrates by high power pulsed microwave plasma assisted chemical vapour deposition (HP-MPCVD) are studied as a function of surface treatments by cathodoluminescence (CL) and photoluminescence (PL) spectroscopies. They are either asgrown, or polished, or etched by a microwave oxygen plasma, or after applying subsequently the two last processes. In CL spectra, bands due to defects occur at 2.3 eV, 3.07 eV, 3.7 eV and 4.7 eV, the last one being specific of polished surfaces, with nearly no contrast in the luminescence image. A fundamental result consists in demonstrating that the defects induced by polishing can be removed by oxygen plasma etching. Additionally, in order to assess how luminescence spectra originate from a peculiar depth or not, a bevelled sample is studied. PL spectra are acquired on the sample side while CL spectra are measured at several points on the bevel top side till to the Ib substrate. Comparison of the two sets of result show that the H3 signal originates from the Ib substrate even if it is present in the CL spectra of the film. An analysis of the change in the intensity of the TO free exciton line, defect bands and H3 signal, along decreasing photon energies, as a function of the thickness of the remaining HP-PMPCVD film, is performed with the help of a model taking the diffusion of the unrecombined excitonic pairs and the re-excited photoluminescence into account. CL images recorded at specific wavelengths, which do not show inverted contrast, are also assessed. From these data, the exciton diffusion length is evaluated to 11 μm in the major part of the epitaxial layer except for the first 20 μm close to the Ib substrate where it decreases down to 2 μm. This study sheds light on the interpretation of luminescence spectra excited by an electron beam in undoped diamond layers. Defects bands due to damages induced by polishing and etching processes are also documented.     

ΔE effect for polycrystalline ferromagnetic rods

We performed experimental and computational studies of the acoustic transfer power coefficient for carbon steel cylindric bars placed in axial magnetic field. By experiment, the transmission coefficients of velocity were measured for ferromagnetic bars during the first magnetization curve below saturation. Using the magnetic and magnetostriction material measurements we obtained the profile of the magnetostriction along the distance for a ferromagnetic cylindrical rod placed in a magnetic field parallel with its axis. The data were compared with numerical results obtained by computer simulation, under the assumption of spatial dependent acoustic impedance and phase velocity, leading to the conclusion that the Young modulus is affected by the magnetoelastic interaction according to a linear decrease.     

Ultra-Small YPO4-YAG:Ce Composite Nanophosphors with a Photoluminescence Quantum Yield Exceeding 50%

Synthesis of high quality colloidal Cerium(III) doped yttrium aluminum garnet (Y₃Al₅O₁₂:Ce³⁺, “YAG:Ce”) nanoparticles (NPs) meeting simultaneously both ultra-small size and high photoluminescence (PL) performance is challenging, as generally a particle size/PL trade-off has been observed for this type of nanomaterials. The glycothermal route is capable to yield ultra-fine crystalline colloidal YAG:Ce nanoparticles with a particle size as small as 10 nm but with quantum yield (QY) no more than 20%. In this paper, the first ultra-small YPO₄-YAG:Ce nanocomposite phosphor particles having an exceptional QY-to-size performance with an QY up to 53% while maintaining the particle size ≈10 nm is reported. The NPs are produced via a phosphoric acid- and extra yttrium acetate-assisted glycothermal synthesis route. Localization of phosphate and extra yttrium entities with respect to cerium centers in the YAG host has been determined by fine structural analysis techniques such as X-ray diffration (XRD), solid state nuclear magnetic resonance (NMR), and high resolution scanning transmission electron microscopy (HR-STEM), and shows distinct YPO₄ and YAG phases. Finally, a correlation between the additive-induced physico-chemical environment change around cerium centers and the increasing PL performance has been suggested based on electron paramagnetic resonance (EPR), X-ray photoelectron spectrometry (XPS) data, and crystallographic simulation studies.     

Advances in Digital Front-End and Software RF Processing:Part I

One of the biggest technology trends in wirelessbroadband, radar, sonar, and broadcasting systems issoftware radio frequency processing and digitalfront-end. This trend encompasses a broad range oftopics, from circuit design and signal processing to systemintegration. It includes digital up-conversion (DUC) and     

Circulating Small EVs miRNAs as Predictors of Pathological Response to Neo-Adjuvant Therapy in Breast Cancer Patients

Neo-adjuvant therapy (NAT) is increasingly used in the clinic for the treatment of breast cancer (BC). Pathological response to NAT has been associated with improved patients’ survival; however, the current techniques employed for assessing the tumor response have significant limitations. Small EVs (sEVs)-encapsulated miRNAs have emerged as promising new biomarkers for diagnosis and prediction. Therefore, our study aims to explore the predictive value of these miRNAs for the pathological response to NAT in BC. By employing bioinformatic tools, we selected a set of miRNAs and evaluated their expression in plasma sEVs and BC biopsies. Twelve miRNAs were identified in sEVs, of which, miR-21-5p, 221-3p, 146a-5p and 26a-5p were significantly associated with the Miller–Payne (MP) pathological response to NAT. Moreover, miR-21-5p, 146a-5p, 26a-5p and miR-24-3p were independent as predictors of MP response to NAT. However, the expression of these miRNAs showed no correlation between sEVs and tissue samples, indicating that the mechanisms of miRNA sorting into sEVs still needs to be elucidated. Functional analysis of miRNA target genes and drug interactions revealed that candidate miRNAs and their targets, can be regulated by different NAT regimens. This evidence supports their role in governing the patients’ therapy response and highlights their potential use as prediction biomarkers.