识别并管理企业的应用个性

很多时候,IT预算只是用来管理并运行企业的基础设施,而不是推动业务创新。不能适应当今迅速变化步伐的老旧系统和应用更加剧了这一问题。这种方式往往会导致企业发展停滞不前,且难以满足不断变化的业务需求。将现代化应用组合进行整合并转换到全新架构将能促进企业发展,能显著提高其敏捷性及创新能力。     

Constructing malware normalizers using term rewriting

A malware mutation engine is able to transform a malicious program to create a different version of the program. Such mutation engines are used at distribution sites or in self-propagating malware in order to create variation in the distributed programs. Program normalization is a way to remove variety introduced by mutation engines, and can thus simplify the problem of detecting variant strains. This paper introduces the “normalizer construction problem” (NCP), and formalizes a restricted form of the problem called “NCP=”, which assumes a model of the engine is already known in the form of a term rewriting system. It is shown that even this restricted version of the problem is undecidable. A procedure is provided that can, in certain cases, automatically solve NCP= from the model of the engine. This procedure is analyzed in conjunction with term rewriting theory to create a list of distinct classes of normalizer construction problems. These classes yield a list of possible attack vectors. Three strategies are defined for approximate solutions of NCP=, and an analysis is provided of the risks they entail. A case study using the virus suggests the approximations may be effective in practice for countering mutated malware. R. Mathur is presently at McAfee AVERT Labs.     

Influence of dietary iron deficiency on acute metal intoxication

The frequent difficulties encountered in the diagnosis of pediatric sarcomas, caused by the lack of observable differentiation at the light microscopic level, has led to the routine use of immunohistochemistry in pediatric surgical pathology. To a large degree the advent of this staining technique has led to the correct assessment of many perplexing lesions that previously would have been given inconclusive diagnoses. However, with increased usage and testing, it has become apparent that there are few, if any, "magic bullets" in immunohistochemistry for pediatric pathologists. Thus, it behooves diagnosticians to be careful in the usage of this technique, to be aware of possible discrepancies in its results, and to remember the ancillary nature of its application. The following article will review selected markers commonly used in pediatric surgical pathology, from both previous reports and the author's perspective, and will briefly consider several new phenotypic markers which have potential utility with childhood sarcomas.     

Massively Parallel Computation Using Graphics Processors with Application to Optimal Experimentation in Dynamic Control

The rapid growth in the performance of graphics hardware, coupled with recent improvements in its programmability has lead to its adoption in many non-graphics applications, including a wide variety of scientific computing fields. At the same time, a number of important dynamic optimal policy problems in economics are athirst of computing power to help overcome dual curses of complexity and dimensionality. We investigate if computational economics may benefit from new tools on a case study of imperfect information dynamic programming problem with learning and experimentation trade-off, that is, a choice between controlling the policy target and learning system parameters. Specifically, we use a model of active learning and control of a linear autoregression with the unknown slope that appeared in a variety of macroeconomic policy and other contexts. The endogeneity of posterior beliefs makes the problem difficult in that the value function need not be convex and the policy function need not be continuous. This complication makes the problem a suitable target for massively-parallel computation using graphics processors (GPUs). Our findings are cautiously optimistic in that the new tools let us easily achieve a factor of 15 performance gain relative to an implementation targeting single-core processors. Further gains up to a factor of 26 are also achievable but lie behind a learning and experimentation barrier of their own. Drawing upon experience with CUDA programming architecture and GPUs provides general lessons on how to best exploit future trends in parallel computation in economics.     

Atropine and exercise-induced bronchoconstriction

Six asthmatic children were studied to determine whether supplemental, parenteral atropine would increase the effects of bronchodilation and protection against exercise-induced bronchoconstriction after maximal effects had been achieved by inhalation. First, we determined the amount of inhaled atropine sulfate that would give maximal bronchodilation for each patient at rest. This quantity of atropine was designated as "A." Then all subjects exercised for five sessions with the following pre-exercise treatments in a random order: (a) inhaled distilled water plus intramuscular (IM) saline solution; (b) inhaled A dose of atropine plus IM saline solution; (c) inhaled distilled water plus 0.35 mg IM atropine; (d) inhaled A dose of atropine plus 0.35 mg IM atropine; and (e) inhaled double the A dose plus IM saline solution. The results showed that the combination of inhaled and IM atropine had the greatest bronchodilation effect and the greatest protection against exercise-induced bronchoconstriction. Atropine inhalation alone (A dose) or IM injection (0.35 mg) was not as effective in bronchodilation or in alleviation of exercise-induced bronchoconstriction. Doubling the dose of inhalation (2A) did not increase the effects of the A dose. These results support the hypothesis that inhaled atropine does not reach all the airways where cholinergic receptors are present.     

Measurement of thrombus formation on intravascular catheters

War is a complex social situation due to the interplay of multiple factors. Economical and political ones are of utmost importance, but human attitudes and motivations must be also taken into account. Being desirable to modify human transactions in such a way that they do not interfere with the basic right of everyone to a condition of physical and mental well-being, war must be abolished. The author contends that an understanding of behaviour through Psychology can be helpful in that aim. Aggression is considered the principal psychological cause of war. It is worth while to differentiate between aggression as an instrument for attaining a special end, and as pure hostility. Only in the first form, it is held here, does it play an important role in war. Psychogists must deal also with a wide range of states of mind that can be "served" by aggression: feelings of inferiority or insecurity, fear, greed, projections, compensations, rationalizations, etc. Scientific approach is not the only one Physiology brings to war prevention. It is equally important the wide dissemination of its conclusions among the general public. Information on the dynamics that prompt people to decide war would make it easier to control. This applies not only to political or military leaders, but also to civil populations. Concerning those two possible contributions of psychologists, scientific and educative, it is suggested the extensive use of psychodramatic techniques. Their richness lie in the lifelike experiences they convey to the participants, and particular aptitude to promote changes of attitudes. Investigation and information on the psychological processes related to war should be undertaken by international organizations of social scientists, acting simultaneously in several countries. Some of the initial steps they could further: 1) that prevention of war be a current subject matter in psychological courses; 2) that the World Health Organization take interest in this subject; 3) that psychologists participate in international political and economical bodies in order to clarify the psychological factors leading to war.     

Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length, and muscle width in growth hormone-deficient children

We have followed the growth of stature, sitting height, skinfolds, muscle widths measured radiologically, and skeletal maturity in growth hormone-deficient patients in whom hGH was given and withheld in alternating three-month periods throughout puberty (referred to as "off-hGH" and "on-hGH" periods). Six boys and four girls had true isolated GH deficiency and developed puberty spontaneously. Two boys had gonadotrophin deficiency plus GH deficiency, and five boys had multiple deficiencies; in these boys the signs of puberty were induced by hormone treatment. Boys with true isolated deficiency grew about two-thirds as much in height in the off-hGH periods as in the on-hGH periods; their total gain in height during the adolescent spurt would have been about 20 cm, instead of 30 cm, if hGH had been discontinued at the beginning of puberty. The effect of hGH was entirely on growth in leg-length, however, which virtually ceased during the off-hGH periods. Growth in sitting height altered little when hGH was withdrawn. Growth in limb muscles, however, was GH dependent throughout puberty; during the majority of periods when hGH was withheld, muscle was actually lost; this occurred in the boys who were receiving large doses of testosterone as well as in those producing their own normal amounts. Subcutaneous fat diminished when hGH was given and increased when it was withdrawn; this occurred independently of administration of testosterone. There was little evidence that growth of pubic and axillary hair progressed faster during on-hGH periods, except perhaps in patients with multiple deficiencies. There was some evidence, however, that bone age progressed less rapidly during on-hGH periods than during off-hGH periods in the patients with isolated deficiency. The results in the girls agreed with those in boys so far as stature was concerned, but the relationship with sitting height and leg length appeared to be different; the reasons for this are discussed. We conclude that all children with GH deficiency should continue on treatment with hGH throughout puberty, ideally until growth ceases.     

高强度φ9.00mm螺旋肋预应力钢丝的研制

阐述了高强度Φ9.00mm螺旋肋预应力钢丝的生产工艺、力学性能和科学的几何外形。生产该钢丝所用原料是77B-1或S82BΦ13.00高线盘条。该钢丝用于建筑构件,可替代热轧带肋钢筋和冷轧带肋钢筋,简化构件生产工艺,节约钢材,降低构件成本,改善建筑结构,增大建筑物有效空间。     

Groundwater Flow and Contaminant Transport Simulation with Imprecise Parameters

A methodology has been developed in this study wherein a genetic algorithm (GA) is used to find a global optimal solution to a groundwater flow and contaminant problem by incorporating an artificial neural network (ANN) to evaluate the objective function within the genetic algorithm. The study shows that an ANN-GA technique can be used to find the uncertainties in output parameters due to imprecision in input parameters. The ANN-GA methodology is applied to five case studies involving radial flow in a well, one-dimensional solute transport in steady uniform flow, a two-dimensional heterogeneous steady flow, a two-dimensional solute transport, and a two-dimensional unsteady groundwater flow to demonstrate the efficiency and effectiveness of the developed algorithm. The results show that, with this approach, one can successfully measure the uncertainty in groundwater flow and contaminant transport simulations and achieve a considerable reduction in computational effort when compared to the vertex method that has been widely used in the past.     

Pinch Roller Failure Analysis and Resulting Enhancement of Rebar Mechanical Properties

Reinforcing bars, popularly termed “rebars,” are used to impart tensile strength to concrete structures. Concrete has high resistance to weathering and fire and high compressive strength but almost no tensile strength, hence rebars are used to provide the latter to concrete. Property consistency along the length of rebars is an important prerequisite. When the finished product is subjected to thermomechanical treatment (TMT), proper control of rolling and water box parameters and efficient pinch rolling are needed to achieve acceptable properties. Variation of yield strength (YS) along TMT bars from the front to back end has been observed within the same heat treatment. In the presented investigation, it was observed that pinch rolling ineffectiveness is the main reason for the poor mechanical properties at the back end. The pinch roller was unable to support the back end of the TMT bars properly to maintain the speed and tension of the bars, resulting in nonuniform cooling of the back end through the water box and subsequent mechanical property failure. Due to the substandard material of the pinch roller, it was unable to hold the back end of the bar properly. Based on analysis of the roller it was concluded that it failed due to improper microstructure, resulting in inadequate hardness and toughness for the stringent operating conditions. AISI H13 is a better material to use in such high-service-temperature conditions. Moreover, proper heat treatment is needed to achieve adequate hardness and microstructure properties. After proper heat treatment of pinch rollers, their service life was increased twofold, minimizing the YS variation along the rebars.