A warm standby redundant system with correlated failures and repairs

This paper presents the analysis of a two-unit warm standby system assuming a bivariate exponential density for the joint distribution of failure and repair times of the units. Investigations regarding the stochastic behaviour and important reliability characteristics of the system have been made and earlier results have been verified as particular cases. A few graphs have also been provided to support the theoretical results.     

Benzodiazepine receptors in the post-mortem brain of suicide victims and schizophrenic subjects

To examine the role of benzodiazepine (BZ) receptors in suicide and schizophrenia, we determined BZ receptors in post-mortem brain (Brodmann's area 10) obtained from suicide victims, schizophrenic patients, and control subjects using [3H]RO15-1788 as the radioligand. The maximum number of binding sites (Bmax) of BZ receptors in the cortex of suicide victims was significantly higher compared with controls, but this increase was mainly due to those suicide victims who died by violent means and whose Bmax was significantly higher than of those who died by non-violent means or control subjects. In schizophrenic patients, Bmax was not significantly different from that of control subjects. When the schizophrenic subjects were separated into two groups, those on neuroleptics and those off neuroleptics for at least 12 months, however, the mean Bmax of BZ receptors in the prefrontal cortex in post-mortem brain obtained from schizophrenic patients on neuroleptics was significantly lower than Bmax in drug-free schizophrenic patients or normal controls. There were no significant differences among groups in values of the apparent dissociation constant (KD) of [3H]RO15-1788 binding. These results suggest that BZ receptors are up-regulated in the cortex of suicide victims, specifically those who used violent means, and that neuroleptic treatment may result in decreased central BZ receptor binding in the cortex of schizophrenic patients. Thus, the method of suicide and previous exposure to neuroleptics should be considered in the interpretation of data on BZ receptors.     

Profit analysis of a k-out-of-n trichotomous system

This paper studies the profit function of a mathematical model of a k-out-of-n trichotomous system. Failure times are assumed to follow negative exponential distributions with different parameters whereas the repair time distributions are taken to be general. The analysis is carried out by using the supplementary variable technique.     

Fabry-Perot optical intensity modulator at 1.3 mu m in silicon

A new type of all-silicon surface-normal optical intensity modulator at 1.3 mu m is reported. It can be easily butt-coupled with a cleaved single-mode fiber. The device utilizes free-carrier effects in silicon to achieve phase modulation and a built-in Fabry-Perot cavity to convert the phase modulation into intensity modulation. A 10% modulation depth with a driving current density as low as 6*10/sup 3/ A/cm/sup 2/ was demonstrated. Because it can be easily coupled with single-mode fiber, and at the same time it is compatible with silicon technology, this device can provide an interface between silicon electronic circuitry and fiber optics in applications such as the fiber-to-home return link where system cost is a deciding figure.<>     

Low-power adaptive filter architectures and their application to51.84 Mb/s ATM-LAN

We present low-power and high-speed algorithms and architectures for complex adaptive filters. These architectures have been derived via the application of algebraic and algorithm transformations. The strength reduction transformation is applied at the algorithmic level as opposed to the traditional application at the architectural level. This results in a power reduction by 21% as compared with the traditional cross-coupled structure. A fine-grained pipelined architecture for the strength-reduced algorithm is then developed via the relaxed lookahead transformation. This technique, which is an approximation of the conventional lookahead computation, maintains the functionality of the algorithm rather than the input-output behavior. Convergence analysis of the proposed architecture is presented and supported via simulation results. The pipelined architecture allows high-speed operation with negligible hardware overhead. It also enables an additional power savings of 39 to 69% when combined with power-supply reduction. Thus, an overall power reduction ranging from 60-90% over the traditional cross-coupled architecture is achieved. The proposed architecture is then employed as a receive equalizer in a communication system for a data rate of 51.84 Mb/s over 100 m of UTP-3 wiring in an ATM-LAN environment. Simulation results indicate that speedups of up to 156 can be achieved with about a 0.8-dB loss in performance     

Expression of pro form of prostate-specific antigen by mammalian cells and its conversion to mature, active form by human kallikrein 2

To study the expression, biosynthesis, and processing of prostate-specific antigen (PSA) in mammalian cells, recombinant PSA was expressed in Syrian hamster tumor cell line AV12-664 (AV12-PSA). Expression of PSA was monitored by the Tandem-MP PSA assay. PSA was secreted into the medium during the logarithmic phase of cell growth at >9 microg/ml and was stable. The PSA purified from spent medium of AV12-PSA cells did not exhibit any enzymatic activity and did not complex with the protease inhibitor, alpha-1-antichymotrypsin. These findings indicated that an inactive form of PSA was expressed by AV12-PSA cells. NH2-terminal sequencing confirmed the identity of the PSA purified from the spent medium of AV12-PSA cells to be pro-PSA. This demonstrates that PSA is expressed as pro-PSA by mammalian cells and suggests that pro-PSA may be present in biological fluids. Human kallikrein 2 (hK2), another member of the hK family, is also expressed predominantly in prostate epithelium. Although hK2 has been shown to exhibit trypsin-like activity, little is known about its natural substrates. Using purified proteins, we show that hK2 can convert pro-PSA to mature, enzymatically active PSA, thus establishing a physiological connection between hK2 and PSA. These findings imply that hK2 may be regulating PSA activity in vivo.     

Demonstration of packet switching through an integrated-optic tree switch using photo-conductive logic gates

Optical routing control of 10 Gbit/s data through a tree-structured photonic switch is experimentally demonstrated. A binary route address within a header is optically processed to control the switch.<>     

Analytical modeling of subthreshold current and subthreshold swing of Gaussiandoped strained-Si-on-insulator MOSFETs

This paper presents the analytical modeling of subthreshold current and subthreshold swing of short- channel fully-depleted （FD） strained-Si-on-insulator （SSOI） MOSFETs having vertical Gaussian-like doping pro- file in the channel. The subthreshold current and subthreshold swing have been derived using the parabolic approx- imation method. In addition to the effect of strain on silicon layer, various other device parameters such as channel length （L）, gate-oxide thickness （tox）, strained-Si channel thickness （ts_Si）, peak doping concentration （Np）, project range （Rp） and straggle （op） of the Gaussian profile have been considered while predicting the device characteris- tics. The present work may help to overcome the degradation in subthreshold characteristics with strain engineering. These subthreshold current and swing models provide valuable information for strained-Si MOSFET design. Ac- curacy of the proposed models is verified using the commercially available ATLASTM, a two-dimensional （2D） device simulator from SILVACO.