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Ana Laura CIMADOR Emeli Luciana GALANTE Lucila Ibel MUÑOZ Patricia Silvia ROMANO Antonella Denisse LOSINNO María Cristina VANRELL 《Biocell》2019,43(1):13-20
Trypanosoma rangeli and T. cruzi are both parasitic unicellular species that infect humans. Unlike T. cruzi,
the causative agent of Chagas disease, T. rangeli is an infective and non-pathogenic parasite for humans, but pathogenic
for vectors from the Rhodnius genus. Because both species can coexist in different hosts and overlap their infective
cycles but very little is known about the infection of T. rangeli in mammalian cells, we decided to characterize both the
development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on
it. We found that T. rangeli exhibits a cycle of infection in Vero cells similar to that for T. cruzi and that the repurposed
drug, 17-AAG, and the natural extract Artemisia sp. essential oil produce a toxic effect on epimastigotes showing
a trypanocidal action from the fifth day of culture. Both treatments also affected the infection of trypomastigotes
and reduced the capacity of replication of amastigotes of T. rangeli. Since T. cruzi / T. rangeli coinfection cases have
been reported, the finding of drugs with potential activity against both species could be significant in the future.
Furthermore, studies of susceptibility of both species to drugs could also help to know the different mechanisms of
pathogenicity in humans displayed by T. cruzi that are absent in T. rangeli 相似文献
124.
Patricia Sastre-Vazquez J. L. Uso-Domenech Jorge Mateu Patricia Salvador Yolanda Villacampa-Esteve 《控制论与系统》2013,44(8):697-724
This paper gives the theoretical setup so that an ecological model, as a particular mathematical model, can be considered a text written in a formal language (mathematics), and therefore, statistical linguistic laws can be applied to obtain information parameters in different semantic levels of the same model. The statistical laws will be useful to: a) compare semantic levels, submodels, and different models mutually; b) prove that information temperature parameter is an indirect measure of meaning: the significance or semantic component of information, opposed to significant, or comprehension, on the part of the observer (modeller) of the model text. We will apply these ideas in two practical examples. 相似文献
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Metal‐Organic Framework Surface Functionalization: GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness (Small 40/2018)
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Gallego-Durán Francisco J. Satorre-Cuerda Rosana Compañ-Rosique Patricia Villagrá-Arnedo Carlos J. Molina-Carmona Rafael Llorens-Largo Faraón 《Universal Access in the Information Society》2021,20(3):479-493
Universal Access in the Information Society - Learning to program is becoming a universally desired ability. Discovering better ways to teach programming and improving existing ones is essential to... 相似文献
129.
Municipal infrastructure for water supply and delivery often does not reach populations in rural and peri-urban areas. This article examines rainwater harvesting as a means of increasing water security in such areas, through the case of Guachtuq, a peri-urban community outside San Cristóbal, Alta Verapaz, Guatemala. The project team designed a rainwater harvesting system to improve three dimensions of water security: quantity, quality and access. The design was implemented for 12 households and evaluated for its contribution to water security and for the potential of expanding project coverage to the region and beyond. The system has improved water security. Several concerns remain, however, regarding the potential of expanding the project to other households in the region and beyond, including system cost, water quality and the individualization of public responsibility for water security. 相似文献
130.
Anthocyanin profile of red fruits and black carrot juices,purees and concentrates by HPLC‐DAD‐ESI/MS‐QTOF
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Patricia Garcia‐Herrera Maria‐Luisa Pérez‐Rodríguez Teresa Aguilera‐Delgado Maria‐Jose Labari‐Reyes Begoña Olmedilla‐Alonso Montana Camara Sonia de Pascual‐Teresa 《International Journal of Food Science & Technology》2016,51(10):2290-2300
A fast and reliable method for anthocyanin extraction and identification by HPLC‐DAD‐ESI/MS‐QTOF was used to analyse the anthocyanin composition of commercial red fruit juices (blackberry, redcurrant and pomegranate), purees (strawberry, cherry and raspberry) and concentrates (elderberry, blueberry and red grape). The anthocyanin profile of black carrot juice is also reported. The extraction and analysis method allowed us to detect and quantify a wide range of individual anthocyanins in a simple and rapid way. Pelargonidin‐3‐glucoside was detected in redcurrant for the first time and petunidin‐3‐galactoside quantified for the first time in blueberries. Considering the health benefits that have been associated with anthocyanin consumption, all these fruit and vegetables processed products could appear as a good source of this group of phytochemical compounds for their direct consumption or their use as ingredients for the design of new food product or food supplements. 相似文献