On deformation and tearing of stiffened and un-stiffened square plates subjected to underwater explosion—a numerical study

In modern combat operations warships can be subjected to underwater blast loads capable of causing considerable structural damage. Research in the field of underwater explosion effects on structures has seen systematic developments since world war-I (WW-I) with the increased awareness that the possible underwater explosions and threats from the hunter killer “U” boats could now be countered. Most of the earlier investigations were conducted by military and these were classified. Cole [1] established empirical relations to model the underwater explosion (UNDEX) loading, which were the outcome of numerous experimental investigations done by the military agencies. In the present study the UNDEX load profile has been modeled as an exponentially decaying shock wave, which varies spatially and transiently. The failure modes in high strength (HS) and WELDOX Steel rectangular plates was predicted using an elasto-plastic model with isotropic hardening, strain rate effects and fracture criterion under clamped edge conditions. These models were implemented in the nonlinear finite element code ABAQUS/Explicit. The present study predicts and establishes the failure modes using a 3D FE analysis.     

Distribution Network Assessment using EPANET for Intermittent and Continuous Water Supply

Drawbacks of intermittent water supply system and inability to shift to continuous supply mode is the main challenge in developing countries. The suitability of the infrastructure laid over past two to three decades to meet the 24/7 demand of todays population is the issue for many water mangers. The present study addresses this issue using EPANET software for a pilot study area in Nagpur city, India. GIS maps, field survey data, remote sensing data and in-situ measurements of pressure and water quality are used in model simulation study. Total 96 artificial reservoirs are inserted into the network which replicate the end-user practices of excess water withdrawal. Reservoirs are assumed connected to damand nodes with equivalent diameter pipes for intermittent supply simulation. For continuous supply, demand multipliers are derived using Monte Carlo simulation. Bulk decay coefficient 0.17 day^?1 for residual chlorine is used in water quality simulation. Simulation scenario of intermittency indicates existing network is not suitable to maintain desired headloss, and pressure in most of the pipes is very low (<1 m). Water age and water quality problems reveal that rehabilitation of distribution mains and critical pipes in the central part is primarily important before implementing 24/7 water supply scheme in the study area.     

Serotonin 5-HT2 receptors in schizophrenia: a PET study using [18F]setoperone in neuroleptic-naive patients and normal subjects

BACKGROUND: In the FRISC trial, dalteparin 120 IU/kg body weight twice daily for unstable coronary artery disease was safe and reduced the risk of new coronary events. This risk reduction was maintained during the following extended treatment with a fixed dose of 7500 IU dalteparin once daily. METHODS AND RESULTS: Minor bleeding was more frequent in women compared with men: relative risk (CI) 2.88 (1.78 to 4.67) during the weight-adjusted and 2.36 (1.37 to 2.63) during the fixed dose treatment. The anti-Xa activity determined in samples (n = 175) obtained during the acute phase treatment was higher in women compared with men (P <.001) and in nonsmokers compared with smokers (<.001) in multiple regression analysis. Also, during the fixed-dose treatment (n = 131) an independent relation between anti-Xa activity and sex (P <.001), but not smoking habits, persisted. CONCLUSION: To improve future low-molecular-weight heparin dose regimens for the treatment of acute coronary syndromes, it might be important to consider the influence of sex and smoking habits.     

Architectural considerations for next-generation file systems

Integration – supporting multiple application classes with heterogeneous performance requirements – is an emerging trend in networks, file systems, and operating systems. We evaluate two architectural alternatives – partitioned and integrated – for designing next-generation file systems. Whereas a partitioned server employs a separate file system for each application class, an integrated file server multiplexes its resources among all application classes; we evaluate the performance of the two architectures with respect to sharing of disk bandwidth among the application classes. We show that although the problem of sharing disk bandwidth in integrated file systems is conceptually similar to that of sharing network link bandwidth in integrated services networks, the arguments that demonstrate the superiority of integrated services networks over separate networks are not applicable to file systems. Furthermore, we show that: an integrated server outperforms the partitioned server in a large operating region and has slightly worse performance in the remaining region; the capacity of an integrated server is larger than that of the partitioned server; and an integrated server outperforms the partitioned server by a factor of up to 6 in the presence of bursty workloads.     

Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia

OBJECTIVE: Dopamine D2 receptor occupancy measurements provide a valid predictor of antipsychotic response, extrapyramidal side effects, and elevation of prolactin levels. The new antipsychotics clozapine, risperidone, and olanzapine obtain antipsychotic response with few extrapyramidal side effects and little prolactin elevation. The purpose of this study was to compare the D2 and serotonin 5-HT2 receptor occupancies of these drugs in patients receiving multiple-dose, steady-state regimens. METHOD: Forty-four patients with schizophrenia (16 taking risperidone, 2-12 mg/day; 17 taking olanzapine, 5-60 mg/day; and 11 taking clozapine, 75-900 mg/day) had their D2 and 5-HT2 occupancies determined with the use of [11C]raclopride and [18F]setoperone, respectively, and positron emission tomography imaging. RESULTS: Clozapine showed a much lower D2 occupancy (16%-68%) than risperidone (63%-89%) and olanzapine (43%-89%). Risperidone and olanzapine gave equal D2 occupancies at doses of 5 and 20 mg/day, respectively. All three drugs showed greater 5-HT2 than D2 occupancy at all doses, although the difference was greatest for clozapine. CONCLUSIONS: Clozapine, at doses known to be effective in routine clinical settings, showed a D2 occupancy clearly lower than that of typical antipsychotics, while risperidone and olanzapine at their usual clinical doses gave the same level of D2 occupancy as low-dose typical antipsychotics. The results also suggest that some previous clinical comparisons of antipsychotics may have been confounded by different levels of D2 occupancy. Clinical comparisons of these drugs, matching for D2 occupancy, may provide a better measure of their true "atypicality" and will help in understanding the contribution of non-D2 receptors to antipsychotic effects.     

Poly(methyl methacrylate) and polyacrylonitrile dispersions stabilized by gelatin

Methyl methacrylate was polymerized in an aqueous medium in the presence of gelatin using potassium persulfate as initiator. The dispersion mode of polymerization, when the monomer is completely miscible with water, was investigated and compared with an emulsion process, which proceeds at higher monomer concentration. Spherical and relatively uniform polymer particles were formed. Macroscopic precipitation of polymer is prevented by combination of the steric stabilization by grafted gelatin and of repulsive electrostatic interactions from the initiator residues attached to the particle surface. Static and dynamic light scattering have been used to determine the molar mass (molar mass of the whole dispersion particle, M_wD ～ 10⁸-10⁹ g mol^?1) and hydrodynamic radius (R_hD ～ 50-120 nm) of the particles. The number of particles per unit volume does not depend on overall monomer concentration, and it is higher, and therefore the particle size is smaller, than that observed for the soapless emulsion polymerization. The addition of gelatin may be thus used to modify the particle size. Acrylonitrile dispersions were prepared under similar conditions. Unlike methyl methacrylate, this monomer does not swell the polymer particles. While poly(methyl methacrylate) particles are spherical and relatively uniform, the polyacrylonitrile dispersions consist of polydisperse aggregates of tiny polymer particles.     

Diamniotic placentation associated with omphalopagus conjoined twins: implications for a contemporary model of conjoined twinning

We have studied omphalopagus conjoined twins with a diamniotic monochorionic placenta. Although conjoined twins usually present in a single amniotic sac, one other example of diamniotic placenta has been reported in omphalopagus twins [Weston et al., 1990: Am J Med Genet 37:558-561]. Most theories concerning the pathogenesis of conjoined twinning exclude the possibility of diamniotic placentation. However, Spencer [1992: Teratology 45:591-602] recently elaborated a model for conjoined twinning based on duplication of organizing centers (primitive streaks) during gastrulation. We have considered the fate of embryonic membranes according to this model of omphalopagus twinning and show that diamniotic placentation is a predictable outcome.     

Analysis of thrust bearings for thermal variations

The interaction between radial and rotational inertia and density-viscosity variations due to temperature changes in a thrust bearing was investigated and a procedure for the optimum design for the load capacity and friction torque was developed.     

A Coordinated Framework of DG Allocation and Operating Strategy in Distribution System for Configuration Management under Varying Loading Patterns

Abstract

The distributed generation (DG) planning with the varying pattern of the practical load is difficult as it calls for the frequent changes in DG size and system configuration, which is neither feasible nor permissible. Rather such a DG size and a configuration, which can be utilized over a wider load pattern, are more acceptable. This work presents a coordinated approach for DG planning and system reconfiguration. While to operate a particular DG size and the system configuration over a wide range of loading pattern, the configurations are ranked under different probabilistic loading patterns. Based upon the ranking of the new configuration, the energy performance of the coordinated planning is evaluated. Further, the observations from coordinated planning are imposed on coordinated operation using harmony search algorithm (HSA). The proposed approach is tested for single as well as multi-objectives on a 33-node system. A significant improvement in the computational efforts and energy performance of the resulting configuration have been observed where losses have reduced to 81.11 and 53.77?kW with single DG and multi-DG allocation respectively.     

On allocation of resources during testing phase of a modular software

To provide reliable software, it is tested over a wide range of testing environment. In the process, testing resources such as time, testing personnel etc. are used. These resources are not infinitely large and therefore need to be used judiciously. In this article, we discuss the testing resource allocation problem among modules to maximize the total fault removal from software consisting of several independent components (modules). For the resulting optimization problem, we define marginal testing effort function (MTEF), where the testing resource consumption is represented in terms of fault removal. The three MTEFs proposed in this article account for both exponential and S-shaped growth curves, which are commonly used in software reliability analysis. Results are illustrated numerically using different data sets.