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21.
Compared to other fields of engineering, in mechanical engineering, the Discrete Element Method (DEM) is not yet a well known
method. Nevertheless, there is a variety of simulation problems where the method has obvious advantages due to its meshless
nature. For problems where several free bodies can collide and break after having been largely deformed, the DEM is the method
of choice. Neighborhood search and collision detection between bodies as well as the separation of large solids into smaller
particles are naturally incorporated in the method. The main DEM algorithm consists of a relatively simple loop that basically
contains the three substeps contact detection, force computation and integration. However, there exists a large variety of
different algorithms to choose the substeps to compose the optimal method for a given problem. In this contribution, we describe
the dynamics of particle systems together with appropriate numerical integration schemes and give an overview over different
types of particle interactions that can be composed to adapt the method to fit to a given simulation problem. Surface triangulations
are used to model complicated, non-convex bodies in contact with particle systems. The capabilities of the method are finally
demonstrated by means of application examples.
Commemorative Contribution. 相似文献
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Theophylline pellets were coated with Eudragit RS 30 D in a miniature fluid-bed pan coater called MiniWiD developed recently. The dispersions were plasticized with varying amounts of triethyl citrate (TEC), dibutyl phthalate (DBP), and polyethylene glycol 6000 (PEG) and applied at different temperatures ranging from 25 to 45 °C. Theophylline release was tested by dissolution using the USP Apparatus 2 (paddle) in 0.1 N hydrochloric acid under sink conditions over 6 hours.
At a coating level of 4 % (0.7 mg/cm2) sustained-release profiles were obtained from dispersions plasticized with TEC or DBP. By reducing the amount of plasticizer from 20 to 10%, films with higher permeabilities were obtained. This effect was compensated by tempering the pellets at 50 deg;C for 24 hours. The coating temperature had little effect on the dissolution profiles of TEC-plasticized films and no effect on films with DBP.
Coatings plasticized with 20% PEG were applied at temperatures ranging from 25 to 45 °C. These films required a coating level of about 18 % (3.3 mg/cm2) to provide comparable sustained-release properties. In contrast to DBP and TEC, a strong influence of the coating temperature on the release rates was observed in which higher temperatures led to slower release rates. This behavior can be explained by the minimum film-forming temperature (MFT). Since PEG does not lower the MFT of Eudragit RS 30 D, the application of these films below the MFT of 45 °C is associated with a lower degree of film formation. 相似文献
At a coating level of 4 % (0.7 mg/cm2) sustained-release profiles were obtained from dispersions plasticized with TEC or DBP. By reducing the amount of plasticizer from 20 to 10%, films with higher permeabilities were obtained. This effect was compensated by tempering the pellets at 50 deg;C for 24 hours. The coating temperature had little effect on the dissolution profiles of TEC-plasticized films and no effect on films with DBP.
Coatings plasticized with 20% PEG were applied at temperatures ranging from 25 to 45 °C. These films required a coating level of about 18 % (3.3 mg/cm2) to provide comparable sustained-release properties. In contrast to DBP and TEC, a strong influence of the coating temperature on the release rates was observed in which higher temperatures led to slower release rates. This behavior can be explained by the minimum film-forming temperature (MFT). Since PEG does not lower the MFT of Eudragit RS 30 D, the application of these films below the MFT of 45 °C is associated with a lower degree of film formation. 相似文献
26.
Peter Fleischmann Ingo Janiszczak 《Applicable Algebra in Engineering, Communication and Computing》1996,7(3):221-234
In this paper an algorithm is presented to determine the number of semisimple conjugacy classes for a given centralizertype for the Chevalley groupsSL
n(q) andSU
n(q). Moreover we give the exact number of regular semisimple classes of this groups and a summary of results on the generic classnumber of exceptional Chevalley groups of adjoint type.The first author acknowledges financial support by a grant of the Deutsche Forschungsgemeinschaft 相似文献
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Management practices for irrigation schemes can often be improved by modelling the behaviour of a scheme and by evaluating its efficiency statistics. However, looking at an irrigation scheme without regard for other water uses within the river basin may not be effective. Efficiencies computed in this way are local and, since water may be used many times within the same basin, may not be realistic. Changes in water uses (e.g. irrigation, industrial, power production, urban water supply, navigation, environmental, recreational) will often have effects on other uses; and changes in irrigation schemes (management,structural, crop pattern) may affect other users within the basin. In addition, all water users will be affected by external changes such as changes in land cover or in climate. As demand for water increases, these links become more important until, at some stage, there is insufficient water for all users and hard choices must be made. Hydrological modelling is a tool that can be used to relate irrigation schemes to the other water uses within a river basin and can help in assessing real productivities and in evaluating alternative patterns of water usage. This paper discusses the techniques available to simulate irrigation schemes within overall basin water resources using, as an example, an intensively utilized basin in western Turkey. 相似文献
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Michael E. G. Ferguson Peter L. Spedding 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1995,63(3):262-278
Experimental data for air–water two-phase co-current flow in two different pipe diameters were used to test the prediction of pressure drop by a number of existing theories and correlations. Several models are shown to be useful for prediction, particularly with the stratified regimes which have proved difficult to handle in the past. The model suggested by Olujic proved to be of particular value. 相似文献