Integral-based filtering of continuous glucose sensor measurements for glycaemic control in critical care

Hyperglycaemia is prevalent in critical illness and increases the risk of further complications and mortality, while tight control can reduce mortality up to 43%. Adaptive control methods are capable of highly accurate, targeted blood glucose regulation using limited numbers of manual measurements due to patient discomfort and labour intensity. Therefore, the option to obtain greater data density using emerging continuous glucose sensing devices is attractive. However, the few such systems currently available can have errors in excess of 20-30%. In contrast, typical bedside testing kits have errors of approximately 7-10%. Despite greater measurement frequency larger errors significantly impact the resulting glucose and patient specific parameter estimates, and thus the control actions determined creating an important safety and performance issue. This paper models the impact of the continuous glucose monitoring system (CGMS, Medtronic, Northridge, CA) on model-based parameter identification and glucose prediction. An integral-based fitting and filtering method is developed to reduce the effect of these errors. A noise model is developed based on CGMS data reported in the literature, and is slightly conservative with a mean Clarke Error Grid (CEG) correlation of R=0.81 (range: 0.68-0.88) as compared to a reported value of R=0.82 in a critical care study. Using 17 virtual patient profiles developed from retrospective clinical data, this noise model was used to test the methods developed. Monte-Carlo simulation for each patient resulted in an average absolute 1-h glucose prediction error of 6.20% (range: 4.97-8.06%) with an average standard deviation per patient of 5.22% (range: 3.26-8.55%). Note that all the methods and results are generalizable to similar applications outside of critical care, such as less acute wards and eventually ambulatory individuals. Clinically, the results show one possible computational method for managing the larger errors encountered in emerging continuous blood glucose sensors, thus enabling their more effective use in clinical glucose regulation studies.     

基于知识网格的电子商务推荐系统设计*

提出电子商务网站、知识网格节点和虚拟知识网格服务社区三级结构模型,建立自动实现商品知识获取、聚合和智能推荐的运作机制,设计了基于知识网格的电子商务智能推荐系统结构。     

实值离散ＧＡＢＯＲ变换及其最优双正交分析窗函数特性

Ｇabor变换在信号、图像处理中是一非常有用的工具。本文首先回顾了作者曾提出的实值离散Gabor变换方法,然后着重讨论了在已知综合窗函数的条件下,双正交分析窗函数的最优解特性,指出在许多情况下,这些最优解（如最小范数解与最优正交解）都是相同的,并讨论了采用奇异值分解（SVD）理论求解双正交分析窗函烽的方法。文末还给出了计算机求解实例。     

Molecular dynamics simulations of oscillatory flows in microfluidic channels

In this paper we apply the direct non-equilibrium molecular dynamics technique to oscillatory flows of fluids in microscopic channels. Initially, we show that the microscopic simulations resemble the macroscopic predictions based on the Navier–Stokes equation very well for large channel width, high density and low temperature. Further simulations for high temperature and low density show that the non-slip boundary condition traditionally used in the macroscopic equation is greatly compromised when the fluid–wall interactions are the same as the fluid–fluid interactions. Simulations of a system with very narrow channel width confirm earlier findings of Poiseuille flow, namely, that the velocity profiles are modulated. We find that these modulations cannot be explained by the local area density model.

Stream segregation algorithm for pattern matching in polyphonic music databases

As music can be represented symbolically, most of the existing methods extend some string matching algorithms to retrieve musical patterns in a music database. However, not all retrieved patterns are perceptually significant because some of them are, in fact, inaudible. Music is perceived in groupings of musical notes called streams. The process of grouping musical notes into streams is called stream segregation. Stream-crossing musical patterns are perceptually insignificant and should be pruned from the retrieval results. This can be done if all musical notes in a music database are segregated into streams and musical patterns are retrieved from the streams. Findings in auditory psychology are utilized in this paper, in which stream segregation is modelled as a clustering process and an adapted single-link clustering algorithm is proposed. Supported by experiments on real music data, streams are identified by the proposed algorithm with considerable accuracy.

企业门户Web资源整合及其实现的研究*

讨论了企业门户Web资源整合中的关键问题,分析并给出了相关整合技术方案。提出了一种特殊的远程门户组件Web服务（WSRP）实现机制WA2WP（Web Application to WSRP Portlet）,可将普通Web网站映射封装为虚拟门户组件发布;给出了改进的跨域单点登录机制SSO4EPI（Single Sign On for Enterprise Portal Integration）,可提供开放的接口形式和对跨安全域异构性的良好支持。最后结合应用实例说明以上方法的可行性和推广价值。     

DNA计算求解连续空间优化问题

首先构造了二进制编码的网络空间,其两个节点连接权的四条边对应到DNA编码,设计了相应的算子起到DNA计算酶的作用,该算法设计使得DNA计算能够求解连续空间优化问题。通过测试函数表明该算法具有较好的收敛速度和稳定性,求解结果非常好。     

基于Agent技术的敏捷虚拟企业信息系统的结构及其原型系统研究*

在分析敏捷虚拟企业定义、特征的基础上,提出了基于Agent技术的敏捷虚拟企业信息系统框架结构,并证明智能体技术在构建敏捷虚拟企业信息系统中的有效性。     

MASCARA中的调度算法—PRADOS

WAND（Wireless ATM Network Demonstrate）是欧洲ACTS（Advanced Communication Technologies and Services）支持的项目之一。在WAND中采用一种基于集线器式、自适应TDMA方式的MAC协议—MASCARA,它通过预约与竞争相结合的方法,为无线ATM（WATM）终端提供具有QoS保证的宽带无线接入。文章着重分析了MASCARA中基于时延的优先权调节调度（PRADOS）算法,并给出了几种不同情况下的算法性能仿真结果。     

对重催I/A'S系统三冲量控制回路的探讨

本文主要对广州石油化工总厂重油催化裂化装置的复杂回路——三冲量控制在I/A'S系统的实现进行探讨和实施。