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排序方式: 共有771条查询结果,搜索用时 490 毫秒
41.
Alessia Costa Barbara Rani Thomaz F. S. Bastiaanssen Francesco Bonfiglio Eoin Gunnigle Gustavo Provensi Moira Rossitto Marcus Boehme Conall Strain Clara S. Martínez Patrizio Blandina John F. Cryan Sophie Lay Renato Corradetti Maria Beatrice Passani 《International journal of molecular sciences》2022,23(2)
Exposure to repeated social stress may cause maladaptive emotional reactions that can be reduced by healthy nutritional supplementation. Histaminergic neurotransmission has a central role in orchestrating specific behavioural responses depending on the homeostatic state of a subject, but it remains to be established if it participates in the protective effects against the insults of chronic stress afforded by a healthy diet. By using C57BL/6J male mice that do not synthesize histamine (Hdc−/−) and their wild type (Hdc+/+) congeners we evaluated if the histaminergic system participates in the protective action of a diet enriched with polyunsaturated fatty acids and vitamin A on the deleterious effect of chronic stress. Behavioural tests across domains relevant to cognition and anxiety were performed. Hippocampal synaptic plasticity, cytokine expression, hippocampal fatty acids, oxylipins and microbiota composition were also assessed. Chronic stress induced social avoidance, poor recognition memory, affected hippocampal long-term potentiation, changed the microbiota profile, brain cytokines, fatty acid and oxylipins composition of both Hdc−/− and Hdc+/+ mice. Dietary enrichment counteracted stress-induced deficits only in Hdc+/+ mice as histamine deficiency prevented almost all the diet-related beneficial effects. Interpretation: Our results reveal a previously unexplored and novel role for brain histamine as a mediator of many favorable effects of the enriched diet. These data present long-reaching perspectives in the field of nutritional neuropsychopharmacology. 相似文献
42.
Sangeetha Jayakumar T. Nandakumar M. Vadivel C. Thinaharan Rani P. George 《Journal of Adhesion Science and Technology》2020,34(7):713-743
AbstractWe report, here, the corrosion inhibition of mild steel specimen in 1?M HCl by tamarind fruit pulp aqueous (TFPA) extract. The inhibition property in the presence of TFPA extract is studied using weight loss, polarization measurement and electrochemical impedance spectroscopy (EIS). The inhibitor efficiency is found to vary from 74% to 88% (weight loss method) with TFPA concentration of 100–600?ppm. The reduction in Tafel slopes shows that TFPA acts as a mixed-type inhibitor. The adsorption of the inhibitor on the metal surface follows Langmuir isotherm. The standard Gibbs free energy of adsorption value of –40?kJ/mol suggests the chemisorption of inhibitor molecules via coordinate bond. AFM results exhibit a decrease in the surface roughness of mild steel, exposed to 1?M HCl from 299?±?12 to 154?±?6.6?nm, with increasing concentration of inhibitor from 0 to 600?ppm due to the uniform coverage of inhibitor molecules on the metal surface. X-ray photoelectron spectroscopy de-convoluted high resolution profiles of C 1?s (carbon) for mild steel exposed to 1?M HCl with 600?ppm inhibitor show major peaks corresponding to sp3 C–C/C–H (284.9?eV) and oxygen bondings in C–OH, C=O, COOH with a binding energy of 285.9, 286.9, 288.5?eV, respectively, thereby confirming the adsorption of organic moieties on mild steel surface. Fourier transform infrared spectroscopy further confirms the adsorption of inhibitor molecules on the metal surface. Therefore, tamarind fruit pulp extract is a potential corrosion inhibitor for mild steel, which is cost-effective, green and non-toxic. 相似文献
43.
Yew Joon Tam Morvarid Akhavan Rezaei Mohd Lila Mohd Azmi Abdul Rani Bahaman Sewn Cen Lo 《分离科学与技术》2016,51(5):816-829
Univariate screening on factors affecting the purification performance of recombinant hepatitis B surface antigen (HBsAg) on ion exchange chromatography (IEC) and size exclusion chromatography (SEC) and the establishment of a two-step purification strategy were performed. Amongst four IEC adsorbents examined, the use of Q Sepharose XL IEC adsorbent under optimized conditions together with optimized SEC purification was able to efficiently purify HBsAg. An established purification strategy comprising the two techniques further demonstrated adaptability for scale-up operations with a final total purification factor (PF) of 94.82 ± 16.20, HBsAg purity of 95.48% and recovery yield of 78.07%. 相似文献
44.
Galvanic black anodizing on Mg-Li alloys 总被引:7,自引:0,他引:7
A. K. Sharma R. Uma Rani H. Bhojaraj H. Narayanamurthy 《Journal of Applied Electrochemistry》1993,23(5):500-507
A process of galvanic black anodizing on Mg-Li alloys was studied. The influence of various operating parameters, namely galvanic current density, voltage, pH, electrolyte concentration, operating temperature, anodizing time and heat treatment on the anodic film formation have been investigated to optimize the process. The deposits were characterized by optical and scanning electron microscopy, adhesion tests, corrosion studies, thickness measurement and microhardness evaluation. The space worthiness of the coatings has been evaluated by humidity, thermal cycling and thermovacuum tests and measurement of optical properties. The results of all these studies are clearly indicative that the black anodizing process described herein is extremely suitable for ground, as well as space, applications.Nomenclature s
Solar absorbance
- ir
Infrared emittance
-
VHN
Vickers hardness number 相似文献
45.
Poonam Sharma Praveen Kumar Dinesh Deva Rohit Shrivastav Sahab Dass Vibha R. Satsangi 《International Journal of Hydrogen Energy》2010
Nanostructured semiconductor thin films of Zn-Fe2O3 modified with underlying layer of Fe-TiO2 have been synthesized and studied as photoelectrode in photoelectrochemical (PEC) cell for generation of hydrogen through water splitting. The Zn-Fe2O3 thin film photoelectrodes were designed for best performance by tailoring thickness of the Fe-TiO2 film. A maximum photocurrent density of 748 μA/cm2 at 0.95 V/SCE and solar to hydrogen conversion efficiency of 0.47% was observed for 0.89 μm thick modified photoelectrode in 1 M NaOH as electrolyte and under 1.5 AM solar simulator. To analyse the PEC results the films were characterized for various physical and semiconducting properties using XRD, SEM, EDX and UV–Visible spectrophotometer. Zn-Fe2O3 thin films modified with Fe-TiO2 exhibited improved visible light absorption. A noticeable change in surface morphology of the modified Zn-Fe2O3 film was observed as compared to the pristine Zn-Fe2O3 film. Flatband potential values calculated from Mott–Schottky curves also supported the PEC response. 相似文献
46.
Marshall B. Elam Matthew A. von Wronski Lauren Cagen Fayanne Thorngate Poonam Kumar Murray Heimberg Henry G. Wilcox 《Lipids》1999,34(8):809-816
We previously demonstrated increased apolipoprotein B (apoB) mRNA editing, elevated levels of mRNA for the catalytic component
of the apoB mRNA editing complex, apobec-1, and increased secretion of the product of the edited mRNA, apoB48, in very low
density lipoproteins (VLDL) in primary cultures of Sprague-Dawley rat hepatocytes following insulin treatment. In order to
determine the effect of in vivo hyperinsulinemia on these processes, we determined apoB mRNA editing, apobec-1 expression, hepatic expression of mRNA for
apoB and other VLDL apoproteins, and the quantity and composition of plasma VLDL in the hyperinsulinemic fatty Zucker rat.
Total apoB mRNA content of the livers of the fatty rats and lean littermates did not differ, however, edited apoB message
coding for hepatic apo B48, and abundance of mRNA for the catalytic subunit of the apoB mRNA editing complex, apobec-1, was
increased by 1.7-and 3.3-fold, respectively, in fatty rats. ApoCIII mRNA abundance was increased in livers of fatty rats as
well, but the abundance of hepatic apoE mRNA in the fatty animal was not different from that of the lean rat. Hepatic apoAI
mRNA abundance was also increased in the fatty rats. Associated with increased apoB mRNA editing, was the 1.7-fold increase
in the fraction of apoB in plasma as apoB48 in fatty rats. VLDL-triglyceride and-apoB in plasma were 15-and 3-fold higher,
respectively, in fatty Zucker rats compared to lean littermates, indicating both enrichment of VLDL with triglycerides and
increased accumulation of VLDL particles. Increased hepatic expression of mRNA for apoCIII and apoAI was associated with increased
content of apoC (and relative depletion of apoE) in VLDL of fatty rats, and plasma apoAI was increased in fatty Zucker rats,
primarily in the HDL fraction. The current study provides further evidence that chronic exposure to high levels of insulin
influences both the quantity of and lipid/apoprotein composition of VLDL in plasma. The increased apoC and decreased apoE
(as well as increased triglyceride) content of VLDL in the fatty Zucker rat observed in the current study may affect VLDL
clearance and therefore may be a factor in the observed accumulation of VLDL in the plasma of the fatty hyperinsulinemic Zucker
rats. 相似文献
47.
The research reported in this paper is concerned with gaining a better understanding of human factors issues in machining and the automation of manufacturing tasks. Mismatches between operators' performance and the requirements of machining tasks were experimentally studied with respect to the relationships with various human characteristics, including skill, age, work experience, self-confidence and trust. Twelve hypotheses concerning interrelationships between these characteristics were evaluated and important relationships established. It is considered that this increased knowledge of the rate of mismatches and an understanding of the causes is essential for the successful design of new working environments, machines and tasks. Much of this change to the working environment is likely to involve some degree of automation of the operators' tasks and so a second and important aspect of the study was designed to establish the extent to which preferred levels of automation were related to the same human characteristics. Four further hypotheses relating preferred levels of automation to skill, age, work experience, self-confidence and trust were tested with results that, in some cases, were unexpected and in others contradict the findings of previous research. 相似文献
48.
Sachin D. Kore P. P. Date S. V. Kulkarni Satendra Kumar Dolly Rani M. R. Kulkarni S. V. Desai R. K. Rajawat K. V. Nagesh D. P. Chakravarty 《The International Journal of Advanced Manufacturing Technology》2011,54(9-12):949-955
The ability to manufacture a product using different metal combinations greatly increases flexibility in design and production. Joining of dissimilar metal combinations like Copper-to-Stainless Steel (Cu-to-SS) is, however, a challenging task owing to the large differences in physical and chemical properties. The application of electromagnetic (EM) impact technique is demonstrated for welding copper (Cu) to stainless steel (SS) sheets. The welding Cu-to-SS is accomplished by using Al drivers to accelerate Cu and SS work sheets. The tensile shear strength test and the metallographic studies are carried out for Cu-to-SS EM welds. 相似文献
49.
50.
Studies on the growth and stability of silver nanoparticles synthesized by electron beam irradiation
Manjunatha Pattabi Rani M. Pattabi Ganesh Sanjeev 《Journal of Materials Science: Materials in Electronics》2009,20(12):1233-1238
Stable Ag nanoparticles have been synthesized by irradiating an aqueous solution of AgNO3 and Poly-vinyl alcohol (PVA) with 8 MeV electrons from a Microtron. The rate of formation of nanoparticles could be controlled by changing either the irradiation dosage or the relative concentration of the precursors. The size, shape, and the rate of formation of the nanoparticles depend on the final dosage, as well as the weight ratio of AgNO3 and PVA. The formation of Ag nanoparticles and their size were established through UV–Vis spectroscopy and Transmission electron microscopy (TEM) analysis, respectively. Increasing the irradiation dosage seem to favour the formation of polygonal nanostructures. Differential scanning calorimetry (DSC) measurements show that there exists a strong interaction between the PVA matrix and the Ag nanoparticles. 相似文献