Scalable Yielding of Highly Stable Polyelectrolyte-Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal-Chemotherapeutics

Photothermal-chemotherapeutic nanoparticles (NPs) are attracting increasing attention and becoming more widely used for cancer therapy in the clinic due to their noninvasiveness, notable tissue penetration abilities, and low systemic adverse effects. However, functional ligands are conventionally modified onto photothermal NPs to well stabilize the inorganic particles suffering from complex chemical modifications, low productivity, and batch-to-batch inconsistencies, and thus significantly restricting their clinical applications. Herein, flash nanoprecipitation (FNP) is taken advantage of to afford rapid and uniform mixing for generating local supersaturated CuS clusters for small and highly stable CuS NPs effectively stabilized by polyacrylic acid through a continuous strategy. It greatly reduces the complexity for CuS NPs synthesis and functionalization in a facile intensified mixing process. These as-synthesized particles are high-drug loading, scalable, and most importantly, it is easy to control their sizes and charges through external conditions. Toxicity and tumor inhibition experiments confirm the high cell toxicity and good suppression of tumor growth under near-infrared irradiation indicating a promising prospect of FNP in the large-scale and continuous yielding of highly stable and high-performing photothermal-chemotherapeutic NPs for cancer therapy.     

声品质技术探讨

伴随着中国的制造业发展,人们越发重视产品噪声对听众心理、生理的影响.从声品质遵照的心理声学理论基础、声品质常用的数据采集分析方法、声品质分析技术的实际应用及现阶段声品质技术的局限和相应的未来工作计划四个方面对声品质技术进行了探讨.     

Tuning a Solvation Structure of Lithium Ions Coordinated with Nitrate Anions through Ionic Liquid-Based Solvent for Highly Stable Lithium Metal Batteries

Rational design of promising electrolyte is considered as an effective strategy to improve the cycling stability of lithium metal batteries (LMBs). Here, an elaborately designed ionic liquid-based electrolyte is proposed that is composed of lithium bis(trifluoromethanesulfonyl)imide as the lithium salt, 1-ethyl-3-methylimidazolium nitrate ionic liquid ([EMIm][NO₃] IL) and fluoroethylene carbonate (FEC) as the functional solvents, and 1,2-dimethoxyethane (DME) as the diluent solvent. Using [EMIm][NO₃] IL as the solvent component facilitates a special Li⁺-coordinated NO₃⁻ solvation structure, which enables the continues electrochemical reduction of solvated NO₃⁻ and the formation of remarkably stable and conductive solid electrolyte interface. With FEC as another functional solvent and DME as the diluent solvent, the formulated electrolyte delivers high oxidative stability and ionic conductivity, and endows improved electrochemical reaction kinetics. Therefore, the formulated electrolyte demonstrates exceedingly reversible and stable Li stripping/plating behavior with high average Coulombic efficiency (98.8%) and ultralong cycling stability (3500 h). Notably, the high-voltage Li|LiNi_0.8Co_0.1Mn_0.1O₂ full cell with IL-based electrolyte exhibits enhanced cyclability with a capacity retention of 65% after 200 cycles under harsh conditions of low negative/positive ratio (3.1) and lean electrolyte (2.5 µL mg⁻¹). This study creates the first NO₃⁻-based ionic liquid electrolyte and evokes the avenue for practical high-voltage LMBs.     

具有负反馈的分段曲率校正CMOS带隙基准源

提出了一种新型带有负反馈的分段曲率校正带隙电压基准源,该基准源的主要特色是利用温度相关的电阻比技术获得一个分段曲率校正电流,校正了一阶带隙基准源的非线性温度特性. 该分段线性电流产生电路还形成了一个负反馈,以改善带隙基准源的电源抑制和线性调整率. 测试结果表明：在2.6V电源电压下,该基准源在没有采用校正的条件下,在-50~125℃温度范围内实现了最大21.2ppm/℃温度系数,电源抑制比为-60dB. 在2.6~5.6V电源电压下的线性调整率为0.8mV/V. 采用中芯国际（SMIC) 0.35μm 5V n阱数字CMOS工艺成功实现,有效芯片面积0.04mm2,其总功耗为0.18mW. 该基准源应用于3, 5V兼容的光纤接收跨阻放大器.     

ZnO纳米棒的图形化生长及其场发射特性

介绍了用氢离子注入技术和阳极腐蚀方法在硼掺杂p-(100)型硅晶片上制备图形化的纳米硅(SiNC)薄膜工艺,并在这种图形化衬底上成功生长了图形化的ZnO纳米棒.场发射测试表明制备的ZnO纳米棒具有良好的场发射性能,即具有较低的开启电场和阈值电场,较高的发射点密度.     

功率密度对VHF-PECVD制备μc-Si:H的影响

在不同功率密度下用甚高频化学气相沉积(VHF-PECVD)法制备了一系列微晶硅(μc-Si:H)薄膜,并对薄膜的微观结构进行了研究.重点研究了在较低的功率密度下,功率密度的改变对薄膜沉积速率和结晶状况的影响.结果表明,随着功率密度的提高,沉积速率逐渐加大,进一步提高功率密度时,沉积速率趋于饱和;与此同时,薄膜的孵化层厚度和形核密度随功率密度而变化.     

汇聚机房与其扩展机房互通优化方案

对老旧汇聚机房和它的扩展汇聚机房间互通光缆消耗过快的问题进行研究,通过对无源/有源波分设备、设备搬迁、光缆优化三种优化方案进行对比,并根据三种优化方案的特点给出适用的场景。     

环形切割器药型罩方案优化设计

在反舰导弹串联战斗部前级环形切割器的设计中优选药型罩材料。通过数值模拟,对铜、钨、铁三种单质药型罩,以及一定比例的两种铜钨复合药型罩的切割效果进行分析。结果表明,五种药型罩方案均能贯穿100mm靶板。铁药型罩和铜含量较少的复合药型罩在靶板底部形成射流堆积巢,钨药型罩和铜含量较多的复合药型罩贯穿后剩余速度较低,切割时间较长。最终确定以铜作为环形切割器的药型罩材料。该结论有助于新型串联战斗部的优化设计。     

基于双方最优控制的微分策略制导

为了提高导弹攻击大机动目标的制导能力,文中提出了双边最优的微分策略制导律。并针对数学上难于求解的两点边值问题,创新性的采用了伴随方法进行求解。在导弹和目标均为一阶时间延迟下推导出微分对策制导的公式,通过与扩展比例导引、单边最优制导的仿真比较,考察脱靶量和控制能量两个指标,得出微分策略制导在理论上的先进性。     

多总线融合式通用自动测试系统设计

为在一个测试系统上能满足更多的测试要求,避免资金浪费和重复性建设,基于PC/104主机设计了一种通用测试系统。该系统能融合多种总线,集成多种仪器,并考虑了网络化和构建大型分布式测试系统的需要,可根据实际需要灵活组配、构建自动测试系统。采用新一代IVI技术,能够较好地实现仪器的互换性,并设计了PC/104总线和MXI总线的转接口,解决了GPIB总线传输速度低的缺点,提高了测试速度。实验表明,PC/104总线和MXI总线间传输速度能达到10 MB/s以上,缩短了测试时间,且系统能够可靠稳定工作。