In this study, first time a nanoformulation, saponin-loaded SBA-15 has been developed for an improved and continuous release. The SBA-15 nanopowder was synthesized by a hydrothermal process. Saponin was introduced into the mesoporous channels of SBA-15 and its concentration in SBA-15 was measured by UV–visible spectrophotometry. The pristine SBA-15 and saponin-loaded SBA-15 were characterized by small-angle XRD, FESEM, HRTEM, TGA, FTIR. N2 adsorption–desorption isotherms were used to measure the specific surface area and pore channel structure parameters of pristine and loaded SBA-15. Saponin release was studied in phosphate buffered saline (pH 7.4), which revealed that the release rate could be effectively controlled. The controlled drug release is highly desired for cancer treatment. The cytotoxicity of pristine and loaded SBA-15 was analyzed on Panc-I cancer cells. Both the pristine SBA-15 and saponin-loaded SBA-15 nanoparticles showed specific toxicity on the cancer cells. The preliminary results showed that saponin-loaded SBA-15 could be an effective therapeutic agent for Panc-I cancer cells. 相似文献
Cultural computing is mainly viewed as the integration of computing technology with the culture. Being inherently interdisciplinary and multidimensional, it requires an explicit comprehension as the way it developed as well as expanded from the history of technological areas. This article addresses the need for cultural computing as well as comprehensively studies existing cultural computing approaches and models from different perspectives. An insight towards dynamics of mind and its incorporation in the virtual world of Internet and social computing has been provided. The article concludes with a summary providing useful suggestions for future developments. 相似文献
Energy conservation in wireless sensor networks (WSNs) is a fundamental issue. For certain surveillance applications in WSN, coverage lifetime is an important issue and this is related to energy consumption significantly. In order to handle these two interlinked aspects in WSN, a new scheme named Weight based Coverage Enhancing Protocol (WCEP) has been introduced. The WCEP aims to obtain longer full coverage and better network life time. The WCEP is based on assigning different weight values to certain governing parameters which are residual energy, overlapping degree, node density and degree of sensor node. These governing parameters affect the energy and coverage aspects predominantly. Further, these four different parameters are prime elements in cluster formation process and node scheduling mechanisms. The weight values help in selection of an optimal group of Cluster Heads and Cluster Members, which result in enhancement of complete coverage lifetime. The simulation results indicate that WCEP performs better in terms of energy consumption also. The enhancement of value 24% in full coverage lifetime has been obtained as compared to established existing techniques.
Energy consumption is one of the important issues in wireless sensor network that rely on non chargeable batteries for power. Also, the sensor network has to maintain a desired sensing coverage area along with periodically sending of the sensed data to the base station. Therefore, coverage and the lifetime are the two important issues that need to be addressed. Effective deployment of wireless sensors is a major concern as the coverage and lifetime of any wireless sensor network depends on it. In this paper, we propose the design of a Probability Density Function (PDF) targeting the desired coverage, and energy efficient node deployment scheme. The suitability of the proposed PDF based node distribution to model the network architecture considered in this work has been analyzed. The PDF divides the deployment area into concentric coronas and provides a probability of occurrence of a node within any corona. Further, the performance of the proposed PDF is evaluated in terms of the coverage, the number of transmissions of packets and the lifetime of the network. The scheme is compared with the existing node deployment schemes based on various distributions. The percentage gain of the proposed PDF based node deployment is 32\(\%\) more than that when compared with the existing schemes. Thus, the simulation results obtained confirm the schemes superiority over the other existing schemes. 相似文献
This paper presents a robust digital video-watermarking system for copyright and copy protection. The proposed method applies the combination of discrete wavelet transform (DWT) and scene-change-detector. For better understanding, this approach can be presented in the form of four stages. The first stage is finding the frame where the watermark is to be inserted. The analysis of watermarking using the level-3 decomposition of LL subband withDWTis described in the second stage. Transparency and the robustness have been analyzed under fifteen different attacks in the third stage. Improvement in the robustness and transparency, as compare to watermarking using different levels of LL subband is calculated in terms of the normalized correlation and the structural similarity index in the fourth stage. The experimental result reveal that the proposed method yields the extracted watermark image and watermarked video of good quality and can sustain different image processing, JPEG compression and geometrical attacks. Empirical results prove the improvement in the performance as the decomposition level increases from level-1 to level-3. Comparative analysis with the existing schemes proves the improved robustness, better imperceptibility and the reduced computational time of the proposed scheme. 相似文献
Network on chip (NoC) is the solution to solve the problem of larger system on chip and bus based communication system. NoC provides scalable, highly reliable and modular approach for on chip communication and related problems. The wireless communication technologies such as IEEE 802.15.4 Zigbee technology follow mesh, star and cluster tree topology. The paper focuses on the development of machine learning model for design and FPGA synthesis of mesh, ring and fat tree NoC for different cluster size (N = 2, 4, 8, 16, 32, 64, 128 and 256). The fat-tree based topologies incorporate more links near the root of the tree, in order to fulfill the requirement for higher communication demand closer to the root of the tree, as compared to its leafs. It is an indirect topology in which not all routers are identical in terms of number of ports connecting to other routers or elements in the network. The research article presents the use of machine learning techniques to predict the FPGA resource utilization for NoC in advance. The present study helps in NoC chip planning before designing the chip itself by taking into account known hardware design parameters, memory utilization and timing parameters such as minimum and maximum period, frequency support etc. The machine learning is carried out based on multiple linear regression, decision tree regression and random forest regression which estimate the accuracy of the design and good performance. The interprocess communication among nodes is verified using Virtex-5 FPGA, in which data flows in packets and can vary up to ‘n’ bit. The designs are developed in Xilinx ISE 14.2 and simulated in Modelsim 10.1b with the help of VHDL programming language. The developed model has been validated and has performed well on independent test data. 相似文献
The paper describes a theoretical study concerning the performance of an externally pressurized multirecess hydrostatic/hybrid flexible journal bearing system by varying the geometric shape of recess and using the membrane flow valve restrictor as a compensating element. The four different recess geometries of the bearing studied in the present study are a square recessed bearing, a circular recessed bearing, an elliptical recessed bearing and a triangular recessed bearing. The equation governing the flow of lubricant in a journal bearing together with 3D elasticity equation and restrictor flow equation are solved by using the Finite Element Method. The study describes the effect of recess shape, bearing flexibility and a method of compensation on the performance characteristics of a hydrostatic/hybrid journal bearing system. A comparative performance of the membrane compensated hydrostatic/hybrid journal bearing system has also been studied vis-à-vis capillary, orifice and constant flow valve restrictors. The results presented in this study amply demonstrate that the shape of recess/pocket of a hydrostatic/hybrid flexible journal bearing system affects the performance of the bearing quite appreciably and a proper selection of recess shape along with a suitable compensating device is needed to get an improved performance from the bearing. 相似文献
To explore the potential of aporphine alkaloids, a novel series of functionalized aporphine analogues with alkoxy (OCH3, OC2H5, OC3H7) functional groups at C1/C2 of ring A and an acyl (COCH3 and COPh) or phenylsulfonyl (SO2Ph and SO2C6H4‐3‐CH3) functionality at the N6 position of ring B of the aporphine scaffold were synthesized and evaluated for their arachidonic acid (AA)‐induced antiplatelet aggregation inhibitory activity and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free‐radical‐scavenging antioxidant activity, with acetylsalicylic acid and ascorbic acid as standard references, respectively. The preliminary structure–activity relationship related to AA‐induced platelet aggregation inhibitory activity results showed that the aporphine analogues 1‐[1,2,9,10‐tetramethoxy‐6a,7‐dihydro‐4H‐dibenzo[de,g]quinolin‐6(5H)‐yl]ethanone and 1‐[2‐(benzyloxy)‐1,9,10‐trimethoxy‐6a,7‐dihydro‐4H‐dibenzo[de,g]quinolin‐6(5H)‐yl]ethanone to be the best compounds of the series. Moreover, the DPPH free‐radical‐scavenging antioxidant activity results demonstrated that the aporphine analogues 1,2,9,10‐tetramethoxy‐6‐(methylsulfonyl)‐5,6,6a,7‐tetrahydro‐4H‐dibenzo[de,g]quinoline, 2‐ethoxy‐1,9,10‐trimethoxy‐6‐(methylsulfonyl)‐5,6,6a,7‐tetrahydro‐4H‐dibenzo[de,g]quinoline, 1‐ethoxy‐2,9,10‐trimethoxy‐6‐(methylsulfonyl)‐5,6,6a,7‐tetrahydro‐4H‐dibenzo[de,g]quinoline, 2,9,10‐trimethoxy‐6‐(methylsulfonyl)‐1‐propoxy‐5,6,6a,7‐tetrahydro‐4H‐dibenzo[de,g]quinoline, and 1‐(benzyloxy)‐2,9,10‐trimethoxy‐6‐(methylsulfonyl)‐5,6,6a,7‐tetrahydro‐4H‐dibenzo[de,g]quinoline were the best compounds of the series. Moreover, in silico molecular docking simulation studies of the active analogues were also performed. 相似文献
We have investigated the effect of C60 concentration on the performance of poly[2-methoxy-5-(2′-ethylhexoxy-p-phenylene vinylene] (MEH-PPV):C60 blend-based Schottky barrier-based devices. Incorporation of C60 in MEH-PPV leads to a red shift and the reduction of intensity in MEH-PPV absorption spectra. The appearance of a C60 characteristic band in the Raman spectra of the composites indicates the presence of C60 in the blends. A FESEM study reveals that the addition of C60 significantly modifies the surface morphology of the blend films. However, higher concentrations (>?5 wt.%) results in agglomeration of C60 particles. Dark I–V measurements allow us to extract various diode parameters including barrier height, ideality factor, and saturation current. Profound variations have been observed in the dominant charge carrier transport mechanism for different C60 concentrations. A photoresponse study demonstrates the enhancement in the photocurrent with the increase in the C60 concentration up to 5 wt.%. Beyond this concentration, agglomeration impedes exciton dissociation and charge transport, which results in a decrease in the photocurrent. Finally, an impedance spectroscopy analysis has been extensively carried out to estimate the internal device parameters, such as junction resistance, capacitance and carrier lifetime. The correlation between these parameters and I–V curves has been established. 相似文献