Functionalization of conducting polymer with novel Co(II) complex: Electroanalysis of ascorbic acid

We report for the first time the functionalization of a conducting polymer with a metal complex in order to develop a new type of catalytic material exhibiting better electronic communication through their delocalized π electrons. The Co(II) complex having hydroxyl group as functional moiety is chemically coupled with carboxyl group of polyanthranilic acid which itself is a self doped conducting polymer. The covalent linkage between Co(II) and –OH group is confirmed using UV–vis, FT-IR and NMR spectroscopic techniques. The Co(II) complex functionalized polymer does exhibit excellent redox behavior and stability with mixed properties of Co(II) complex and π-conjugated polymer. The material possesses potential benefits in sensors/biosensor applications and it is demonstrated for the electroanalysis of ascorbic acid at a level of nano molar concentration.     

Electrospray mass spectrometric characterization of bimetallic group 8 — Gold clusters

Bimetallic clusters containing gold in conjunction with Group 8 metals have been intensively studied as it is proposed that these compounds may find uses as catalysts or materials (or as precursors to catalysts/materials). These types of compounds are very difficult to characterize by the mass spectrometric techniques traditionally used to analyse transition metal clusters. In this paper we report a derivatization method employing electrospray ionization mass spectrometry that is reliable and informative for these types of compounds.     

Hot wire chemical vapor processing (HWCVP) — A prospective tool for VLSI

Today the Very Large Scale Industry (VLSI) is looking towards process solutions, which will avoid the problems associated with the conventional or presently employed technologies. This demand has become more intense with the VLSI industry extending their horizons towards Micro electro-mechanical systems (MEMS) based devices and Application-Specific Integrated Circuits ASICs). The areas of concern are development of high-k dielectric thin films, highly conducting polysilicon thin films, ultra thin diffusion barriers on low dielectric constant layers with electromigration resistant metal interconnects. Over the last few years, work carried out on the hot wire chemical vapor process (HWCVP) has shown that, this technique has great potential to yield the desired materials at low processing temperatures. This paper discusses the results we have obtained in the above areas and also the extension of application of this technique to areas like MEMS and ASICs.     

Response Time in Data Broadcast Systems: Mean,Variance and Tradeoff

Data broadcast has been suggested as a promising method of information dissemination [2,33]. In such an environment, the information server cannot afford to serve the requests from a large population of users individually. Instead, the server uses a broadcast channel to deliver information to all users. A single transmission of a data item satisfies all pending requests for that item. The response time of a request depends on the broadcast time of the desired data item, which is scheduled by the server according to the overall demands for various data items. Therefore, the response time may vary in a large range. We argue that, in addition to mean response time, the variance of response time should also be taken into account by the broadcast scheduler. In this paper, we address the issue of variance optimization in regard to response time. Building on our previous research on mean response time optimization, we propose an algorithm which can minimize the variance of response time. Furthermore, we evaluate an algorithm that facilitates a tradeoff between the mean and variance of response time. Numerical examples that illustrate the performance of our algorithms are also presented.     

Early Experiences in Cross‐Disciplinary Education in Biomedical Technology Innovation at Stanford University*

This paper describes two new educational programs at Stanford that address some of the unique issues in teaching medical technology innovation and design. The first is a team‐based medical device design and prototyping course that is based on clinical immersion and “hands‐on” device prototyping. Medical device innovation at Stanford is further encouraged by means of a series of university‐wide competitions, called Invention Challenges, to invent solutions to defined clinical problems with the potential for real‐world impact.     

A new method for reducing DNL in nuclear ADCs using an interpolation technique

The paper describes a new method for reducing the DNL associated with nuclear ADCs. The method named the “interpolation technique” is utilized to derive the quantisation steps corresponding to the last n bits of the digital code by dividing quantisation steps due to higher significant bits of the DAC, using a chain of resistors. Using comparators, these quantisation steps are compared with the analog voltage to be digitized, which is applied as a voltage shift at both ends of this chain. The output states of the comparators define the n bit code. The errors due to offset voltages and bias currents of the comparators are statistically neutralized by changing the polarity of quantisation steps as well as the polarity of analog voltage corresponding to last n bits) for alternate A/D conversion. The effect of averaging on the channel profile can be minimized. A 12 bit ADC was constructured using this technique which gives DNL of less than ±1% over most of the channels for conversion time of nearly 4.5 μs. Gatti's sliding scale technique can be implemented for further reduction of DNL. The interpolation technique has a promising potential of improving the resolution of existing 12 bit ADCs to 16 bit, without degrading the percentage DNL significantly.     

Mirna Expression in Glaucomatous and TGFβ2 Treated Lamina Cribrosa Cells

Glaucoma is a group of optic neuropathies that leads to irreversible vision loss. The optic nerve head (ONH) is the site of initial optic nerve damage in glaucoma. ONH-derived lamina cribrosa (LC) cells synthesize extracellular matrix (ECM) proteins; however, these cells are adversely affected in glaucoma and cause detrimental changes to the ONH. LC cells respond to mechanical strain by increasing the profibrotic cytokine transforming growth factor-beta 2 (TGFβ2) and ECM proteins. Moreover, microRNAs (miRNAs or miR) regulate ECM gene expression in different fibrotic diseases, including glaucoma. A delicate homeostatic balance between profibrotic and anti-fibrotic miRNAs may contribute to the remodeling of ONH. This study aimed to determine whether modulation of miRNAs alters the expression of ECM in human LC cells. Primary human normal and glaucoma LC cells were grown to confluency and treated with or without TGFβ2 for 24 h. Differences in expression of miRNAs were analyzed using miRNA qPCR arrays. miRNA PCR arrays showed that the miR-29 family was significantly decreased in glaucomatous LC cell strains compared to age-matched controls. TGFβ2 treatment downregulated the expression of multiple miRNAs, including miR-29c-3p, compared to controls in LC cells. LC cells transfected with miR-29c-3p mimics or inhibitors modulated collagen expression.