Advances in the Therapeutic Effects of Apoptotic Bodies on Systemic Diseases

Apoptosis plays an important role in development and in the maintenance of homeostasis. Apoptotic bodies (ApoBDs) are specifically generated from apoptotic cells and can contain a large variety of biological molecules, which are of great significance in intercellular communications and the regulation of phagocytes. Emerging evidence in recent years has shown that ApoBDs are essential for maintaining homeostasis, including systemic bone density and immune regulation as well as tissue regeneration. Moreover, studies have revealed the therapeutic effects of ApoBDs on systemic diseases, including cancer, atherosclerosis, diabetes, hepatic fibrosis, and wound healing, which can be used to treat potential targets. This review summarizes current research on the generation, application, and reconstruction of ApoBDs regarding their functions in cellular regulation and on systemic diseases, providing strong evidence and therapeutic strategies for further insights into related diseases.     

Wave-induced flow of pore fluid in a cracked porous solid containing penny-shaped inclusions

An aim of current study is to analyze the contribution of reflected longitudinal waves to wave-induced fluid flow(WIFF)in the cracked porous solid.Initially,we ...     

A near-optimum detector with reduced out-of band response fornarrowband signals

Reduced spectral response in adjacent spectral bins is very desirable for detectors since it gives capability to detect narrowband signals in the presence of unknown interference and colored noise. Conventionally, this is achieved by applying a smoothing window on the signal at the cost of detection performance. In this correspondence, a new method of detecting narrowband signals that uses a close approximation to the matched filter and the extrapolated input signal is proposed. The filter used has a frequency response that is very closely equal to that of the matched filter within a Doppler bin and nearly zero response outside it     

Generalized form of optimal teleportation witnesses

We propose a generalized form of optimal teleportation witness to demonstrate their importance in experimental detection of the larger set of entangled states useful for teleportation in higher dimensional systems. The interesting properties of our witness reveal that teleportation witness can be used to characterize mixed state entanglement using Schmidt numbers. Our results show that while every teleportation witness is also a entanglement witness, the converse is not true. Also, we show that a hermitian operator is a teleportation witness iff it is a decomposable entanglement witness. In addition, we analyze the practical significance of our study by decomposing our teleportation witness in terms of Pauli and Gell-Mann matrices, which are experimentally measurable quantities.     

Purification and identification of antioxidant peptide from black pomfret, <Emphasis Type=Italic>Parastromateus niger</Emphasis> (Bloch, 1975) viscera protein hydrolysate

To utilize fish waste, black pomfret, Parastromateus niger viscera was analysed for its proximate and amino acid composition followed by hydrolysis using various proteases to extract antioxidant peptide. Antioxidant activities of the crude hydrolysate was evaluated using DPPH (54%), metal chelating (78.6%) at a concentration of 1 mg/mL, whereas the reducing power assay was done with different concentration (0.5–2.5 mg/mL) and the activity also increased with increasing concentration (0.021–0.068). Furthermore, the hydrolysate was purified by diethylaminoethyl (DEAE) ion-exchange and Sephadex G-25 gel filtration chromatography. Finally, the purified peptide had a mass of 701.9 Da, and the amino acid sequence was identified as Ala-Met-Thr-Gly-Leu-Glu-Ala using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). Moreover, the protection ability of the peptide toward hydroxyl radical-induced oxidative DNA damage and inhibiting lipid peroxidation was evaluated and compared with natural antioxidant α-tocopherol.