Lipopolysaccharide and its analog antagonists display differential serum factor dependencies for induction of cytokine genes in murine macrophages

Monocytes/macrophages play a central role in mediating the effects of lipopolysaccharide (LPS) derived from gram-negative bacteria by the production of proinflammatory mediators. Recently, it was shown that the expression of cytokine genes for tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interferon-inducible protein-10 (IP-10) by murine macrophages in response to low concentrations of LPS is entirely CD14 dependent. In this report, we show that murine macrophages respond to low concentrations of LPS (相似文献   

Long-term results of fasting. Results from 132 consecutive patients after 1-6 1/2 years

132 consecutive patients were reexamined 1-6.5 years (m = 2.8) after total fasting in hospital. 37 patients had continued to lose weight, 20 patients had maintained their fasting result (+/-2 kg) and 7 patients had slightly regained (less than 1/3 of their weight loss during fast). These 3 groups, totalling 64 patients (48%), were considered successful. Their mean overweight was diminished from 57 to 29%, corresponding to a 60% reduction of mortality in certain age groups. On the other hand, 63 patients (48%) had regained more than 1/3 of their original weight loss. Five patients (4%) were lost to follow-up. Selection of patients and long-term follow-up appeared to have a decisive bearing on long-term results of fasting, whereas factors such as age, sex, degree of overweight, onset of overweight in childhood and sports were without significant effect. From the long-term results presented, it is concluded that under certain conditions fasting in hospital is warranted. Behaviour therapy is a possible alternative in the treatment of obesity.     

Zusammenhang zwischen physikalischer struktur und textilen eigenschaften von faserneuentwicklungen

By means of a series of methods of investigations, especially of X-ray wide and small angle scattering, the so-called supermolecular structure of synthetic fibres can be detected. From aromatic polyamides on the oné hand mainly amorphous fibres with a high water absorption can be produced while on the other hand fibres with an extremely high elastic modulus are obtainable. Polypropylene and polypivalolactone filaments show elastomeric character due to a special micromorphological lamellar structure.     

Rehaltersbestimmung bei unterschiedlicher Backenzahnabnutzung

Ohne Zusammenfassung     

Measurement of experimentally induced affects.

This article describes the development of a Multiple Affect Adjective Check List designed to measure day to day changes in three affects: anxiety, depression, and hostility. Empirical criteria were used to select items and the scales were validated in several types of experimental situations. A stressful film resulted in significant increases in the Anxiety and Depression scales in females, but not in males. A "surprise exam" threat resulted in significant increases in all scales, but the greatest increase was on Hostility. Prior to an expected examination only the Anxiety scale was significantly elevated. All 3 scales responded significantly to an induced failure situation. Group means were stable over base-line days and high split-half reliabilities were found for all scales. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Gas diffusion and electrolyte penetration in porous gas diffusion electrodes

Gas diffusion and electrolyte penetration in wetproofed gas diffusion electrodes were studied using layers of PTFE-bonded carbon. Minor variations in fabrication and testing procedures resulted in very large variations in catalyst layer wetting characteristics and permeability for gases. The results indicate that the flooded agglomerate model satisfactorily explains the essential features of such electrodes. Apparently contradictory behavior is the result of variations in the state of the PTFE in such structures but does not, however, require a different model.     

X-ray protection zones during x-ray examens in intensive care (author's transl)]

For x-ray examens in intensiv care units is shown that in a distance of 1,5 m or 2,0 m the registered doses are so low that the x-ray protection zones could be limeted to this area.