Aligning scan acquisition circles in optical coherence tomography images of the retinal nerve fibre layer

Optical coherence tomography (OCT) is widely used in the assessment of retinal nerve fibre layer thickness (RNFLT) in glaucoma. Images are typically acquired with a circular scan around the optic nerve head. Accurate registration of OCT scans is essential for measurement reproducibility and longitudinal examination. This study developed and evaluated a special image registration algorithm to align the location of the OCT scan circles to the vessel features in the retina using probabilistic modelling that was optimised by an expectation-maximization algorithm. Evaluation of the method on 18 patients undergoing large number of scans indicated improved data acquisition and better reproducibility of measured RNFLT when scanning circles were closely matched. The proposed method enables clinicians to consider the RNFLT measurement and its scan circle location on the retina in tandem, reducing RNFLT measurement variability and assisting detection of real change of RNFLT in the longitudinal assessment of glaucoma.     

Fast timing-based algorithms

Summary.  Concurrent systems in which there is a known upper bound Δ on memory access time are considered. Two prototypical synchronization problems, mutual exclusion and consensus, are studied, and solutions that have constant (i.e. independent of Δ and the total number of processes) time complexity in the absence of contention are presented. For mutual exclusion, in the absence of contention, a process needs only five accesses to the shared memory to enter its critical section, and in the presence of contention, the winning process may need to delay itself for 4 ⋅ Δ time units. For consensus, in absence of contention, a process decides after four accesses to the shared memory, and in the presence of contention, it may need to delay itself for Δ time units. Received: July 1993/Accepted: February 1996     

Conference report. Bioengineering in the millennium. National Institute of Health symposium bioengineering--building the future of biology and medicine

Reducing the Risk is a theory-based, sexuality education curriculum shown to influence the knowledge and behaviors of secondary students. This study determined whether the behavioral effects of the curriculum could be duplicated in a southern, rural state. In a quasiexperimental design, pretest and posttest inventories were administered to students in treatment and comparison groups to determine the influence of Reducing the Risk on sexual behaviors. Results of the 18-month study indicated students receiving the curriculum significantly delayed initiating sexual intercourse. Sexually active students in the treatment group were significantly more likely to protect themselves from STD/HIV and pregnancy than sexually active students in the comparison group. In addition, students receiving Reducing the Risk showed a significant increase in parent-child communication about sexual issues. These results reinforce previous research that found positive behavioral effects for students receiving the Reducing the Risk curriculum.     

Conservative Visibility and Strong Occlusion for Viewspace Partitioning of Densely Occluded Scenes

Computing the visibility of out-door scenes is often much harder than of in-door scenes. A typical urban scene, for example, is densely occluded, and it is effective to precompute its visibility space, since from a given point only a small fraction of the scene is visible. The difficulty is that although the majority of objects are hidden, some parts might be visible at a distance in an arbitrary location, and it is not clear how to detect them quickly. In this paper we present a method to partition the viewspace into cells containing a conservative superset of the visible objects. For a given cell the method tests the visibility of all the objects in the scene. For each object it searches for a strong occluder which guarantees that the object is not visible from any point within the cell. We show analytically that in a densely occluded scene, the vast majority of objects are strongly occluded, and the overhead of using conservative visibility (rather than visibility) is small. These results are further supported by our experimental results. We also analyze the cost of the method and discuss its effectiveness.     

Tight bounds for shared memory systems accessed by Byzantine processes

We provide efficient constructions and tight bounds for shared memory systems accessed by n processes, up to t of which may exhibit Byzantine failures, in a model previously explored by Malkhi et al. [21]. We show that sticky bits are universal in the Byzantine failure model for n ≥ 3t + 1, an improvement over the previous result requiring n ≥ (2t + 1)(t + 1). Our result follows from a new strong consensus construction that uses sticky bits and tolerates t Byzantine failures among n processes for any n ≥ 3t + 1, the best possible bound on n for strong consensus. We also present tight bounds on the efficiency of implementations of strong consensus objects from sticky bits and similar primitive objects. Research supported in part by a grant from the Israel Science Foundation, and by the Hermann Minkowski Minerva Center for Geometry at Tel Aviv University. This work was partially completed while at AT&T Labs and while visiting the Institute for Advanced Study, Princeton, NJ. Research supported in part by US-Israel Binational Science Foundation Grant 2002246. This work was partially completed while visiting AT&T Labs. This work was partially completed while at AT&T Labs. Research supported in part by the National Science Foundation under Grant No. CCR-0331584. A preliminary version of the results presented in this paper appeared in [23].     

Effect of impact energy on the shape of granular heaps

We study experimentally the shape of a granular heap formed pouring a granular material into a vertical Hele-Shaw cell and analyze the effect of the grain impact energy. We propose a continuous model for the steady profile of the heap that explicitly considers energy dissipation of flowing grains through inelastic collisions. We solve the model analytically and analyze the resulting height profile as a function of several parameters, such as the restitution coefficient of the grains and their impact energies. We find good agreement between theory and experiments. Received: 9 June 1999     

Alignment of 3-D optical coherence tomography scans to correct eye movement using a particle filtering

Eye movement artifacts occurring during 3-D optical coherence tomography (OCT) scanning is a well-recognized problem that may adversely affect image analysis and interpretation. A particle filtering algorithm is presented in this paper to correct motion in a 3-D dataset by considering eye movement as a target tracking problem in a dynamic system. The proposed particle filtering algorithm is an independent 3-D alignment approach, which does not rely on any reference image. 3-D OCT data is considered as a dynamic system, while the location of each A-scan is represented by the state space. A particle set is used to approximate the probability density of the state in the dynamic system. The state of the system is updated frame by frame to detect A-scan movement. The proposed method was applied on both simulated data for objective evaluation and experimental data for subjective evaluation. The sensitivity and specificity of the x-movement detection were 98.85% and 99.43%, respectively, in the simulated data. For the experimental data (74 3-D OCT images), all the images were improved after z-alignment, while 81.1% images were improved after x-alignment. The proposed algorithm is an efficient way to align 3-D OCT volume data and correct the eye movement without using references.     

Improved Thermoelectric Properties of Se-Doped n-Type PbTe1−x Se x (0 ≤ x ≤ 1)

Enhancement of the thermoelectric figure of merit is of prime importance for any thermoelectric material. Lead telluride has received attention as a potential thermoelectric material. In this work, the effect of Se substitution has been systematically investigated in PbTe_1?x Se _x . The thermoelectric properties of synthesized alloys were measured in the temperature range of 300 K to 873 K. For the particular composition of x = 0.5, α was highest at ~292 μV/K, while k was lowest at ~0.75 W/m-K, resulting in the highest dimensionless figure of merit of ZT ≈ 0.95 at 600 K. The increase in thermopower for x = 0.5 can be attributed to the high distortion in the crystal lattice which leads to the formation of defect states. These defect states scatter the majority charge carriers, leading to high thermopower and high electrical resistivity. The dramatic reduction of the thermal conductivity for x = 0.5 can be attributed to phonon scattering by defect states.     

Atmospheric Fine and Coarse Mode Aerosols at Different Environments of India and the Bay of Bengal During Winter-2014: Implications of a Coordinated Campaign

In this paper, we present mass concentrations of particulate matter [PM_2.5, PM₁₀ size fractions and total suspended particulates (TSP)] measured simultaneously over land stations (Kullu, Patiala, Delhi, Ajmer, Agra, Lucknow, Varanasi, Giridih, Kolkata, Darjeeling, Jorhat, Itanagar, Imphal, Bhubaneswar, and Kadapa), mostly distributed across the Indo-Gangetic plain (IGP) of India as well as in the marine atmosphere over Bay of Bengal (BoB) in the period from 20 January to 3 February, 2014. The main objective of this study was to quantify the continental outflow of particulates (PM_2.5, PM₁₀ and TSP) from IGP and associated regions into the BoB along with low level north-east wind flow during winter monsoon period. The present study provides a glimpse of the aerosol loading over the IGP region. During this campaign, the highest average PM_2.5 (187.8 ± 36.5 µg m^?3, range 125.6–256.2 µg m^?3), PM₁₀ (272.6 ± 102.9 µg m^?3, range 147.6–520.1 µg m^?3) and TSP (325.0 ± 71.5 µg m^?3, range 220.4–536.6 µg m^?3) mass concentrations were recorded at Varanasi, Kolkata and Lucknow over middle and lower IGP regions. The PM_2.5 (average 41.3 ± 11.9 µg m^?3; range 15.0–54.4 µg m^?3), PM₁₀ (average 53.9 ± 18.9 µg m^?3; range 30.1–82.1 µg m^?3) and TSP (average 78.8 ± 29.7 µg m^?3; range 49.1–184.5 µg m^?3) loading over BoB were found to be comparable to land stations and suggests possible continental outflow. Over the continental region, the highest PM_2.5/PM₁₀ ratio was recorded at Delhi (0.87). The PM_2.5/PM₁₀ ratio over BoB (0.77) was found to be quite high and comparable to Varanasi (0.80) and Agra (0.79).     

Interrelation of Chemistry and Process Design in Biodiesel Manufacturing by Heterogeneous Catalysis

The pros and cons of using heterogeneous catalysis for biodiesel manufacturing are introduced, and explained from a chemistry and engineering viewpoint. Transesterification reactions of various feed types are then compared in batch and continuous process operation modes. The results show that the reaction chemistry and process kinetics characterising a particular feedstock are determinant factors for obtaining high-grade biodiesel. When using heterogeneous catalysis, the biodiesel quality of a particular feed can be controlled by customising the process design and operation conditions.