A coprecipitation technique to prepare Sro.5Bao.5Nb206

An aqueous mixture of ammonium oxalate and ammonium hydroxide was used to coprecipitate barium and strontium ions as oxalates and niobium ions as hydroxide under basic conditions. This precursor on calcining at 750°C yielded Sr_0.5Ba_0.5Nb₂O₆ phase. This is a much lower temperature than that prepared by traditional solid state method (1000°C) as reported for the formation of Sr_0.5Ba_0.5Nb₂0₆ (SBN). Transmission electron microscopic (TEM) investigations revealed that the average particle size was 80 nm for the calcined powders. The room temperature dielectric constant at 1 kHz was found to be 1100. The ferroelectric hysteresis loop parameters of these samples were also studied.     

Selective flocculation of iron oxide-kaolin mixtures using a modified polyacrylamide flocculant

High molecular weight polyacrylamides were synthesized and successfully modified to contain up to 8·3% hydroxamate functional groups. The selective flocculation tests carried out on 1:1 iron oxide/kaolin mixtures using parent polyacrylamide, polyacrylic acid and the modified polyacrylamide, confirm the possibility of enhancing selectivity through introduction of iron chelating functional groups in commercially available polymers. Starting with a feed grade of 35% iron, 92% recovery with acceptable grade of 60% iron has been achieved using the modified polyacrylamide. NCL communication No. 4415     

Preprocessing embedded actions

Some parser generators allow the user to attach actions, consisting of executable code, to syntax rules. Actions are usually in the local programming language, so they are simply copied into the generated parser. However, we show two situations in which it is convenient to allow actions to be in a different notation. A preprocessor is used to translate such notations into the local programming language. A preprocessor must know where to find actions and how to translate them. We show how these two activities can be programmed separately. Often, the user only has to worry about the second part: once the parser generator is known, the placement of the actions is known as well, so routines for finding actions can be separately compiled and linked in. Examples in the paper are based on the parser generator Yacc, but the approach is not limited to Yacc, or even to parser generators. Certain compositions of syntax-directed translations can be implemented by preprocessing actions.     

Cationic poly(lactide-co-glycolide) nanoparticles as efficient in vivo gene transfection agents

Poly(lactide-co-glycolide) (PLGA), a biocompatible and biodegradable polyester co-polymer of PLA and PGA, has been recognized for its ability to deliver genes. However, gene delivery by PLGA nanoparticles is limited by their negative charge and their poor transport through mucosal barriers. In this study, PLGA nanoparticles were surface modified with cationic chitosan in an effort to improve their gene delivery capability. PLGA nanoparticles were synthesized by emulsion-diffusion-evaporation technique using PVA-chitosan (PLGA1) or PVA-chitosan-PEG (PLGA2) blend as stabilizers. This method is reproducible and produces nanoparticles with hydrodynamic diameter <200 nm. The nanoparticles were characterized by zetasizer, photon correlation spectroscopy and atomic force microscopy. A549 epithelial cells were transfected in vitro with PLGA particles complexed with a reporter plasmid encoding green fluorescent protein. PLGA particles transferred EGFP gene, but were less efficient than the lipofectamine control. The nanoparticles were also tested for their ability to transport across the nasal mucosa in vivo in mice. The results show that both PLGA1 and PLGA2 facilitate gene delivery and expression in vivo with increased efficiency and without causing inflammation, as measured by IL-6. Together, these results indicate that chitosan-modified PLGA nanoparticles have greater potential as gene carriers.     

Relationship analysis in requirements engineering

This research addresses a major shortcoming in todays requirements analysis techniques—the lack of a rigorous and comprehensive process to explicitly capture the relationship structure of the problem domain. Whereas other analysis techniques lightly address the relationship discovery process, relationship analysis (RA) is a systematic, domain-independent analysis technique focusing exclusively on a domains relationship structure. This paper describes RAs taxonomy of relationship types and corresponding brainstorming questions for eliciting the relationship structure from a domain expert. A preliminary case study analysis of online bookstores using RA as well as a formal experiment have both confirmed RAs effectiveness in helping the analyst produce significantly higher quality requirements. RA should become an invaluable tool for analysts, irrespective of the software engineering approach taken during systems analysis.     

Socket Buffer Auto-Sizing for High-Performance Data Transfers

It is often claimed that TCP is not a suitable transport protocol for data intensive Grid applications in high-performance networks. We argue that this is not necessarily the case. Without changing the TCP protocol, congestion control, or implementation, we show that an appropriately tuned TCP bulk transfer can saturate the available bandwidth of a network path. The proposed technique, called SOBAS, is based on automatic socket buffer sizing at the application layer. In non-congested paths, SOBAS limits the socket buffer size based on direct measurements of the received throughput and of the corresponding round-trip time. The key idea is that the send window should be limited, after the transfer has saturated the available bandwidth in the path, so that the transfer does not cause buffer overflows (self-induced losses). A difference with other socket buffer sizing schemes is that SOBAS does not require prior knowledge of the path characteristics, and it can be performed while the transfer is in progress. Experimental results in several high bandwidth-delay product paths show that SOBAS provides consistently a significant throughput increase (20% to 80%) compared to TCP transfers that use the maximum possible socket buffer size. We expect that SOBAS will be mostly useful for applications such as GridFTP in non-congested wide-area networks.     

经济型19"机柜系统的选择

在"911"之后的经济环境条件下,设计工程师和系统集成者们在搭建一个经济型19"机柜系统时,总是要面对一个棘手的任务--如何找出蕴涵的价值.     

Si nanocolumns as novel nanostructured supports for enzyme immobilization

Silicon nanocolumns have been used as novel supports for the high-density immobilization of enzymes. Silicon nanocolumns with diameters of ca. 50-100 nm and a height of 1 micron were constructed using glancing angle deposition. The surfaces were successively treated with 3-aminopropyltriethoxysilane (APTES) and then with an amine reactive polymer, poly(ethylene-alt-maleic anhydride), to attach soybean peroxidase (SBP) to the support. Optimal coverage of APTES, polymer, and SBP was obtained for incorporation of enzyme onto the sidewalls of the nanocolumns. SBP immobilized on the silicon nanocolumns demonstrated an enhancement in biocatalytic activity of 160% over that of the enzyme immobilized on flat silicon wafers with the same projected area. The enzymatic activity decreased with progressive washes for both supports. This decrease in the activity of enzyme was found to be primarily due to the intrinsic deactivation of immobilized enzyme on the silicon surface. Designing nanocolumns with optimal dimensions, spacing, and surface chemistry may lead to the development of high-density arrays of proteins for applications in biotechnology.