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71.
Reza Samavi Eric Yu Thodoros Topaloglou 《Information Systems and E-Business Management》2009,7(2):171-198
Strategic reasoning about business models is an integral part of service design. In fast moving markets, businesses must be able to recognize and respond strategically to disruptive change. They have to answer questions such as: what are the threats and opportunities in emerging technologies and innovations? How should they target customer groups? Who are their real competitors? How will competitive battles take shape? In this paper we define a strategic modeling framework to help understand and analyze the goals, intentions, roles, and the rationale behind the strategic actions in a business environment. This understanding is necessary in order to improve existing or design new services. The key component of the framework is a strategic business model ontology for representing and analyzing business models and strategies, using the i* agent and goal oriented methodology as a basis. The ontology introduces a strategy layer which reasons about alternative strategies that are realized in the operational layer. The framework is evaluated using a retroactive example of disruptive technology in the telecommunication services sector from the literature. 相似文献
72.
Ali Nouri Qarahasanlou Reza Khalokakaie Mohammad Ataei Behzad Ghodrati 《Journal of Failure Analysis and Prevention》2017,17(1):56-67
When a system’s performance is inadequate, the concept of availability importance can be used to improve it. The availability of an item depends on the combined aspects of its reliability and maintainability. In a system consisting of many subsystems, the availability of some subsystems is more important to system performance than others. The availability measure determines the priority of availability across subsystems. Most researchers only consider operation time and ignore the influence of the operating environment; therefore, their estimations are not accurate enough. In contrast to previous research, we focus on the influence of the operating environment on the system/subsystem’s characteristics with a view to prioritizing them based on the importance of availability. The paper considers part of the mining fleet system of Sungun copper mine, including the wagon drill, loader, bulldozer, and dump truck subsystems. We identify an ordered list of possibilities for availability improvement and suggest changes or remedial actions for each item to either reduce its failure rate or reduce the time required to repair it. 相似文献
73.
Khondakar Kamil Reza Jing Wang Ramanathan Vaidyanathan Shuvashis Dey Yuling Wang Matt Trau 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(9)
Cancer diagnosis and patient monitoring require sensitive and simultaneous measurement of multiple cancer biomarkers considering that single biomarker analysis present inadequate information on the underlying biological transformations. Thus, development of sensitive and selective assays for multiple biomarker detection might improve clinical diagnosis and expedite the treatment process. Herein, a microfluidic platform for the rapid, sensitive, and parallel detection of multiple cancer‐specific protein biomarkers from complex biological samples is presented. This approach utilizes alternating current electrohydrodynamic‐induced surface shear forces that provide exquisite control over fluid flow thereby enhancing target–sensor interactions and minimizing non‐specific binding. Further, the use of surface‐enhanced Raman scattering‐based spectral encoding with individual barcodes for different targets enables specific and simultaneous detection of captured protein biomarkers. Using this approach, the specific and sensitive detection of clinically relevant biomarkers including human epidermal growth factor receptor 2 (HER2); Mucin 1, cell surface associated (MUC1); epidermal growth factor receptor; and Mucin 16, cell surface associated (MUC16) at concentrations as low as 10 fg mL?1 in patient serum is demonstrated. Successful target detection from patient samples further demonstrates the potential of this current approach for the clinical diagnosis, which envisages a clinical translation for a rapid and sensitive appraisal of clinical samples in cancer diagnostics. 相似文献
74.
Seyed Mohammad Reza Derakhshandeh Seyed Mohammad Mehdi Hadavi Mohammad Javad Eshraghi Masoumeh Javaheri Masoud Mozafari 《IET nanobiotechnology / IET》2017,11(6):656
In this study, hydrogenated amorphous carbon thin films, structurally similar to diamond‐like carbon (DLC), were deposited on the surface of untreated and plasma nitrocarburised (Nitrocarburizing‐treated) stainless steel medical implants using a plasma‐enhanced chemical vapour deposition method. The deposited DLC thin films on the nitrocarburising‐treated implants (CN+DLC) exhibited an appropriate adhesion to the substrates. The results clearly indicated that the applied DLC thin films showed excellent pitting and corrosion resistance with no considerable damage on the surface in comparison with the other samples. The CN+DLC thin films could be considered as an efficient approach for improving the biocompatibility and chemical inertness of metallic implants.Inspec keywords: tissue engineering, bone, biomedical materials, electrochemistry, amorphous state, carbon, hydrogen, thin films, plasma CVD, adhesion, corrosion resistance, surface hardeningOther keywords: electrochemical performance, plasma nitrocarburised stainless steel medical implants, hydrogenated amorphous carbon thin films, bone tissue engineering, plasma‐enhanced chemical vapour deposition method, adhesion, corrosion resistance, biocompatibility, chemical inertness, metallic implants, C:H 相似文献
75.
Change Point Estimation in the Mean of Multivariate Linear Profiles with No Change Type Assumption via Dynamic Linear Model
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Mona Ayoubi Reza Baradaran Kazemzadeh Rassoul Noorossana 《Quality and Reliability Engineering International》2016,32(2):403-433
Change point estimation is a useful concept that helps quality engineers to effectively search for assignable causes and improve quality of the process or product. In this paper, the maximum likelihood approach is developed to estimate change point in the mean of multivariate linear profiles in Phase II. After the change point, parameters are estimated through filtering and smoothing approaches in dynamic linear model. The proposed change point estimator can be applied without any prior knowledge about the change type against existing estimators which assume change type is known in advance. Besides, sporadic change point can be identified as well. Simulation results show the effectiveness of the proposed estimators to estimate step, drift and monotonic, as well as sporadic changes in small to large shifts. In addition, effect of different values of the Multivariate Exponentially Weighted Moving Average (MEWMA) control chart smoothing coefficient on the performance of the proposed estimator is investigated presenting that the smoothing estimator has more uniform performance. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
76.
Faranak Mavandadnejad Mohammad Hossein Yazdi Seyed Mehdi Hassanzadeh Mehdi Mahdavi Mohammad Ali Faramarzi Hamidreza PazokiToroudi Ahmad Reza Shahverdi 《IET nanobiotechnology / IET》2018,12(1):57
Conventional hepatitis B vaccine contains alum but is less effective to induce Th1 response. Selenium nanoparticles and Bacillus Calmette–Guerin were reported as immune modulators. In this study, SeNPs were extracted from Mycobacterium bovis and characterised. SeNPs were mixed with HBs‐Ag and administered to the mice to investigate he immune response pattern. With an addition of Se ions at a sub‐inhibitory concentration to the Sauton medium broth after 24 h, SeNPs were extracted from M. bovis and characterised by Fourier transform infrared spectroscopy, dynamic light scattering, atomic forcemicroscopy, energy dispersive X‐ray spectrum, transmission electron microscopy, and thermogravimetric analysis. Furthermore, female inbred BALB/c mice were injected subcutaneously on the first, 14th, 28th day with 100 and 200 µg doses of that SeNPs supplemented with HBs‐Ag vaccine. Later, the total antibody, isotypes of Immunoglobulin G1, Interlukin 4, and interferon‐γ were measured by enzye‐linked immunosorbent assay. The size of the SeNPs was <150 nm. Level of total antibody and immunoglobulin G2a increased significantly in the group that received 200 µg/ml nano selenium extracted from M. bovis. SeNPs in dose of 200 µg coated with organic materials of M. bovis could induce an influential immune response in relation to the conventional HBs‐Ag vaccine.Inspec keywords: selenium, nanoparticles, nanofabrication, microorganisms, Fourier transform spectra, infrared spectra, light scattering, atomic force microscopy, X‐ray chemical analysis, transmission electron microscopy, thermal analysis, nanomedicineOther keywords: biosynthesis, selenium nanoparticles, Mycobacterium bovis, enhnced immune response, HBs antigens, Bacillus Calmette‐Guerin, immune modulators, biogenic SeNPs, immune response pattern, Sauton medium broth, Fourier transform infrared spectroscopy, dynamic light scattering, atomic force microscopy, energy dispersive X‐ray spectrum, transmission electron microscopy, thermogravimetric analysis, female inbred BALB/c mice, antibody, IgG1 isotype, IgG2a isotype, IL4 isotype, interferon‐γ, enzyme‐linked immunosorbent assay, bacterium, time 24 h, time 14 day, time 28 day, Se 相似文献
77.
Magnetic nanoparticles (NPs) were functionalised with soy protein isolate (SPI) and bovine serum albumin (BSA) for inulinase immobilisation. The results revealed the nanomagnetite size of about 50 nm with a polydispersity index (PDI) of 0.242. The average size of the SPI NPs prepared by using acetone was 80–90 nm (PDI, 0.277), and SPI–BSA NPs was 80–90 nm (PDI, 0.233), and their zeta potential was around −34 mV. The mean diameter of fabricated Fe3 O4 @SPI–BSA NPs was <120 nm (PDI, 0.187). Inulinase was covalently immobilised successfully through glutaraldehyde on Fe3 O4 @SPI–BSA NPs with 80% enzyme loading. Fourier transform infrared spectra, field emission scanning electron microscopy, and transmission electron microscopy images provided sufficient proof for enzyme immobilisation on the NPs. The immobilised inulinase showed maximal activity at 45°C, which was 5°C higher than the optimum temperature of the free enzyme. Also, the optimum pH of the immobilised enzyme was shifted from 6 to 5.5. Thermal stability of the enzyme was considerably increased to about 43% at 75°C, and K m value was reduced to 25.4% after immobilisation. The half‐life of the enzyme increased about 5.13‐fold at 75°C as compared with the free form. Immobilised inulinase retained over 80% of its activity after ten cycles.Inspec keywords: magnetic particles, nanoparticles, proteins, molecular biophysics, nanofabrication, enzymes, Fourier transform spectra, infrared spectra, scanning electron microscopy, field emission ion microscopy, transmission electron microscopy, pH, biochemistry, nanobiotechnology, biomagnetism, electrokinetic effects, iron compoundsOther keywords: magnetic nanoparticles, soy protein isolate, bovine serum albumin, inulinase immobilisation, nanomagnetite, polydispersity index, SPI‐BSA NP, zeta potential, inulinase, glutaraldehyde, enzyme loading, Fourier transform infrared spectra, field emission scanning electron microscopy, transmission electron microscopy images, enzyme immobilisation, pH, size 80 nm to 90 nm, temperature 45 degC, temperature 75 degC, Fe3 O4 相似文献
78.
Ali Reza Allafchian Seyed Amir Hossein Jalali Farzane Aghaei Hamid Reza Farhang 《IET nanobiotechnology / IET》2018,12(5):574
The metal nanoparticles, due to interesting features such as electrical, optical, chemical and magnetic properties, have been investigated repeatedly. Also, the mentioned nanoparticles have specific uses in terms of their antibacterial activity. The biosynthesis method is more appropriate than the chemical method for producing the nanoparticles because it does not need any special facilities; it is also economically affordable. In the current study, the silver nanoparticles (AgNPs) were obtained by using a very simple and low‐cost method via Glaucium corniculatum (L.) Curtis plant extract. The characteristics of the AgNPs were investigated using techniques including: X‐ray diffraction, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy. The SEM and TEM images showed that the nanoparticles had a spherical shape, and the mean diameter of them was 53.7 and 45 nm, respectively. The results of the disc diffusion test used for measuring the anti‐bacterial activity of the synthesised nanoparticles indicated that the formed nanoparticles possessed a suitable anti‐bacterial activity.Inspec keywords: silver, nanoparticles, antibacterial activity, nanomedicine, nanofabrication, X‐ray diffraction, transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectraOther keywords: green synthesis, silver nanoparticles, Glaucium corniculatum Curtis extract, antibacterial activity, metal nanoparticles, biosynthesis method, X‐ray diffraction, transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, SEM, TEM, spherical shape, disc diffusion test, Ag 相似文献
79.
In this article, the design and realization of waveguide filter with improved stop‐band response is presented. By inserting transversal slots at the proper position of cavities, without disturbing the field distribution of the dominant mode, the second longitudinal resonant modes are radiated out. This caused the out‐of‐band frequency response of the filter to be improved. The validity of the proposed technique is confirmed by comparison between measurement values and simulation results from the finite element method through the commercial software (high frequency structure simulator). Also, to assure electromagnetic compatibility the slot surfaces are covered by absorbing material. © 2011 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2011. 相似文献
80.
Bus terminal assignment with the objective of maximizing public transportation service is known as bus terminal location problem (BTLP). We formulate the BTLP, a problem of concern in transportation industry, as a p-uncapacitated facility location problem (p-UFLP) with distance constraint. The p-UFLP being NP-hard (Krarup and Pruzan, 1990), we propose evolutionary algorithms for its solution. According to the No Free Lunch theorem and the good efficiency of the distinctive preserve recombination (DPX) operator, we design a new recombination operator for solving a BTLP by new evolutionary and memetic algorithms namely, genetic local search algorithms (GLS). We also define the potential objective function (POF) for the nodes and design a new mutation operator based on POF. To make the memetic algorithm faster, we estimate the variation of the objective function based on POF in the local search as part of an operator in memetic algorithms. Finally, we explore numerically the performance of nine proposed algorithms on over a thousand randomly generated problems and select the best two algorithms for further testing. The comparative studies show that our new hybrid algorithm composing the evolutionary algorithm with the GLS outperforms the multistart simulated annealing algorithm. 相似文献