Magnetic properties and phase diagram of Ni50Mn50−xGax ferromagnetic shape memory alloys

We present the magnetic properties and the magnetic phase diagram of Ni₅₀Mn_50?xGa_x ferromagnetic shape memory alloys across a wide concentration range. Martensitic transformation, intermediate transformation, B2–L2₁ order–disorder transformation, Néel and Curie temperatures are determined for the prepared samples. The martensitic transformation temperature decreases with increasing Ga concentration and bends two times when crossing the Curie temperature and the intermediate-phase transformation temperature. Spontaneous magnetization and its composition dependence were also investigated. Composition dependence of the transformation temperatures and the spontaneous magnetization in the martensite phase of Ni₅₀Mn_50?xGa_x are compared with those of Ni₅₀Mn_50?xIn_x and Ni₅₀Mn_50?xSn_x, revealing a similarity in the NiMn-based alloy systems.     

PACVD-Beschichtung von Druckgußwerkzeugen unter ökonomischen und ökologischen Gesichtspunkten

Application of Wear Resistant PACVD-Coatings in Aluminium Diecasting under Economical and Ecological Aspects Aluminium pressure diecasting is a frequently applied manufacturing process for the near netshape production of precision parts. State of the art production techniques still demand considerable amounts of die lubricants. But the side effects of these lubricants include a decrease in surface quality of the cast part as well as a prolongation of the casting cycle time. The job quality decreases and the waste and exhaust disposal during production and application of lubricants is ecologically risky. In this study different wear resistant coating systems have been developed in order to minimize the use of die lubricants in the casting process while at the same time increasing the service life of the diecasting tools. Nitrides, carbides and borides of titanium were synthesized by means of DC-pulse-PACVD. The influence of the process parameters gas composition, pressure, voltage and pulse/pulse repetition ratio was investigated. Compositional analysis was performed by analytical methods such as XRD, EDS, WDS and SIMS. Hardness, adhesion and friction behaviour of the layers were determined in order to describe their mechanical properties. The wetting angle was determined and the corrosion resistance was evaluated in dip tests in aluminium melt. A selection of the best coatings was then compared in diecasting praxis tests under tightened-up conditions reducing the amount of lubricants. TiN, Ti(B,N), TiC and multilayers of the system Ti-C-N were deposited exhibiting a wide range of stoichiometry. The coatings reached hardness values of up to 4400 HK0.005 and the friction coefficient μ was in the range of 0.3. In the diecasting praxis test the amount of die lubricant could be reduced by 97%. Under most severe conditions all layer types led to a minimum increase in the lifetime of the tool of factor 60 compared to an untreated dummy. A strong dependence on the layer type and on its stoichiometry could be observed. Ti(B,N) as the most successful coating in this study has not yet shown any sign of failure and already achieved an increase in lifetime of 300 times.     

Porcine enamel matrix derivative enhances the formation of reparative dentine and dentine bridges during wound healing of amputated rat molars

We examined the biological effects of porcine enamel matrix derivative (EMD; Emdogain) on the formation of reparative dentine and dentine bridges in rat molars after pulp amputation. The pulp chambers of upper molars of Wistar rats were perforated and the amputated pulp surfaces were directly capped with either EMD or its carrier propylene glycol alginate (PGA) as control. The cavities were then restored with glass-ionomer cement. On post-amputation days 4-30, the dissected maxillae were examined by light and electron microscopy. In PGA-capped pulp, reparative dentine had been formed over the dentine walls under the prepared cavity on day 7 post-amputation and its thickness extended until day 30. On day 30, as well as reparative dentine formation, diffuse calcification had occurred beneath the amputated wound surfaces. Dentine bridge formation under the amputated coronal pulp surface was observed in 18.2% of amputated pulp on day 30. In EMD-capped pulp, reparative dentine had already been formed by odontoblast-like cells over the dentine walls, already on day 4 post-amputation, and its thickness extended until day 30. The Ca and P weight % and Ca/P ratio of reparative dentine matrix were similar to those of pre-existing dentine matrix, and these values were not different between PGA and EMD-capped pulp. Dentine bridge formation was observed in 27.3% of EMD-capped pulp on day 30. Our results suggest that EMD enhances the formation of both reparative dentine and dentine bridges during wound healing of amputated rat molar pulp.     

Study of local intracellular signals regulating axonal morphogenesis using a microfluidic device

The establishment and maintenance of axonal patterning is crucial for neuronal function. To identify the molecular systems that operate locally to control axonal structure, it is important to manipulate molecular functions in restricted subcellular areas for a long period of time. Microfluidic devices can be powerful tools for such purposes. In this study, we demonstrate the application of a microfluidic device to clarify the function of local Ca²⁺ signals in axons. Membrane depolarization significantly induced axonal branch-extension in cultured cerebellar granule neurons (CGNs). Local application of nifedipine using a polydimethylsiloxane (PDMS)-based microfluidic device demonstrated that Ca²⁺ entry from the axonal region via L-type voltage-dependent calcium channels (L-VDCC) is required for branch extension. Furthermore, we developed a method for locally controlling protein levels by combining genetic techniques and use of a microfluidic culture system. A vector for enhanced green fluorescent protein (EGFP) fused to a destabilizing domain derived from E. coli dihydrofolate reductase (ecDHFR) is introduced in neurons by electroporation. By local application of the DHFR ligand, trimethoprim (TMP) using a microfluidic device, we were able to manipulate differentially the level of fusion protein between axons and somatodendrites. The present study revealed the effectiveness of microfluidic devices to address fundamental biological issues at subcellular levels, and the possibility of their development in combination with molecular techniques.     

NEW APPROACH FOR ESTIMATION OF ΔJ AND FOR MEASUREMENT OF CRACK GROWTH AT ELEVATED TEMPERATURE

Abstract— The ACPD-method was used to measure crack growth in low cycle fatigue tests at elevated temperature. The material which was investigated at T = 550°C was the ferritic steel 2.25Cr–1Mo. Characteristic values of representative hysteresis loops were determined. The crack growth data were correlated with the effective part of the fracture mechanics parameter Δ J. A new method for the calculation of Δ J is proposed.     

Investigation of the voltage life of mica-alumina composite insulation at high temperatures

Experiments and investigations were carried out on the voltage life of a bar-coil model with a nickel-plated copper conductor covered with mica-alumina composite insulation at a temperature range of 550–850 °C. Diffusion of copper into the insulation layer was observed on the specimens aged for a long period. Insulation with mica paper gave faster diffusion speed and shorter voltage life than insulation with mica flake. The diffusion speed became higher with an increase in temperature. The ac current gradually increased with aging time and increased rapidly just before breakdown. There was the relationship I = aEⁿ (a, n: constants) between ac current I and applied stress E, and n was approximately equal to 1 in the region where thermal unbalance did not occur. Arrhenius's law held in the relationship between ac current and aging time. Therefore, the breakdown mechanism might be that the effective insulation thickness decreased due to copper diffusion into the insulation layer and the ac current increased gradually until thermal breakdown in the last stage. If copper diffuses into the insulation layer, even with no voltage application, the aging time required to decrease the breakdown voltage to a certain level (the voltage life) obeys Arrhenius's law. If the voltage life is dominated by diffusion into the insulation layer, the activation energy for voltage life in the aging test becomes twice that for diffusion, both with and without voltage application. © 1999 Scripta Technica, Electr Eng Jpn, 129(4): 24–31, 1999     

The effect of small dose of topiroxostat on serum uric acid in patients receiving hemodialysis

Introduction : Topiroxostat, a recently developed xanthine oxidase inhibitor, is expected to have fewer adverse effects than allopurinol because it has different mechanism of action from alloprinol. However, its dosage, usage and safety have not been established in patients with impaired renal function or those undergoing dialysis at the development since no studies was conducted in these patients. Methods : Cross over clinical trial using 3 months of allopurinol and topiroxostat on 27 maintain Japanese HD patients were carried out. The effects on oxidative stress status of both drugs were also evaluated by measuring oxidation reduction potential. Findings : Twenty‐five of twenty‐seven patients completed study. The mean serum uric acid levels in the topiroxostat‐treated arm was significantly lower than it in the allopurinol‐treated arm time‐dependently (P < 0.0001). Corrected oxidative stress ratio defined as biological antioxidant potential/diacron reactive oxygen metabolites was significantly increased in topiroxostat‐arm (*P = 0.0035), but not in allopurinol‐arm (P = 0.1429). No significant difference was seen in diacron reactive oxygen metabolites, biological antioxidant potential, static oxidation‐reduction potential, and capacity oxidation‐reduction potential between pre and post treatment of both drugs. Discussion : It is suggested that a low dose of topiroxostat decreased serum uric acid sufficiently to maintain it below 7.0 mg/dL in patients receiving hemodialysis.     

配电线路线损管理系统的应用及功能完善

通过分析营销配电线损管理系统应用现状,发现线损管理系统功能及系统应用过程中存在供电量和售电量调整不规范、调整电量方式未控制、调整电量未参与对网线损统计、未与综合线损统计同步等问题,提出规范调整供电量行为、严格控制调整电量的方式、设置调整电量参与对网线损统计等完善措施以解决问题。     

Optimizing PSMA Radioligand Therapy for Patients with Metastatic Castration-Resistant Prostate Cancer. A Systematic Review and Meta-Analysis

The aim of the review was to evaluate patient and treatment characteristics for patients with metastatic castration-resistant prostate cancer (mCRPC) treated with PSMA radioligand therapy (PRLT) associated with above-average outcome. The systematic review and meta-analysis followed recommendations by the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA). We searched for publications in PubMed, Embase, and ClinicalTrials.gov up to 31 September 2020. Thirty-six publications and four duplicates reported 2346 patients. Nearly two-thirds of the patients had bone metastases. Median overall survival (OS) was 16 months. Asymptomatic patients and patients with only lymph node metastases lived longer than symptomatic patients and patients with more extensive metastases. Patients treated with an intensified schedule of ¹⁷⁷Lu PRLT lived longer than those treated with a conventional schedule. Half of the patients obtained a PSA decline ≥ 50% and these patients lived longer than those with less PSA decline. Approximately 10% of the patients developed hematologic toxicity with anemia grade 3 as the most severe adverse effect. Characteristics for patients, cancer, restaging, and PRLT predict above average overall survival following treatment with PRLT.     

Lipid distribution on cotton textiles in relation to washing with cellulase

Enzymes are used widely as effective additives to laundry detergents for improved detergency on soiled fabric. They have potential for cleaning of “dingy” soils in addition to the stain removal benefits. Cellulases contribute to the overall whiteness of cotton-containing textiles when worn and washed several times, meaning that their cleaning is not associated solely with the regions characterized by high amounts of fatty material, e.g., collars/cuffs. The focus of this research was to study further the performance of cellulases for whiteness maintenance of cotton textiles. Cotton garments soiled by multiple wearings and washed using a cellulase treatment were evaluated using scanning electron microscopy and X-ray microanalysis. Washing with cellulase significantly reduced residual soil concentrations at all morphological locations on the cotton fibers for each set of matched garments. The relative concentrations of residual soil on the fabrics agreed well with the color differences measured at 440 nm. Cellulase affected removal of oily soil from within the cotton fiber secondary wall, resulting in residual oil concentrations similar to those at morphological locations that were more accessible for detergency such as the fiber surface and crenulations. Since cellulase hydrolyzes cellulose, it was expected that the effect would be within the structure of the fiber, i.e., secondary wall. The cellulase effect on redeposition garments was similar to garments worn and washed. As with lipase, the enhanced removal of soil from the interior bulk structure of the cotton fiber with use of cellulase is unique, since most other detergent components have higher functionality at fabric, yarn, and fiber surfaces. We think that cellulase is functioning by hydrolyzing cellulose from the internal surfaces of fibrils within the secondary wall, opening up the pore structure for enhanced detergency and forming a new surface with each washing.