Initial-stage Sintering Kinetics of Nanocrystalline Tungsten

Initial-stage sintering kinetics of nanocrystalline tungsten has been studied in the temperature range of 1273–1473 K (1000–1200 °C). Nanocrystalline tungsten sinters initially through a grain boundary diffusion mechanism. The calculated activation energy was 388 ± 11 kJ/mol at low temperatures (1273–1373 K (1000–1100 °C)) and 409 ± 7 kJ/mol at high temperatures (1373–1473 K (1100–1200 °C)), which are close to the experimentally measured activation energy for grain boundary diffusion (385 kJ/mol).     

A two dissimilar unit multi-component system with correlated failures and repairs

This paper investigates a two non-identical unit cold standby system model. Each unit is composed of n independent components arranged in a series configuration. A single repairman is available to repair a failed unit. The priority in operation is being given to the first unit, while in repair the priority is given to the second unit. The failure and repair times of the ith and jth component for the first and second unit, respectively, are jointly distributed as bivariate exponentials (B.V.E.) with different parameters. Using a regenerative point technique, various reliability characteristics have been analysed.     

Cost-benefit analysis of a two-unit standby system with a proviso of repair-machine failure

This paper deals with the cost analysis of a two-unit (priority and ordinary) cold standby system model under a very practicable assumption that the repair machine (R.M.) may also fail during the repair of a failed unit. Some important measures of system effectiveness are obtained by using the regenerative point technique (R.P.T.).     

The role of prior experience and task characteristics in object-oriented modeling: an empirical study

The object-oriented methodology for systems analysis and design has generated considerable interest recently. Object-orientation represents a fundamental shift in focus from the traditional process-oriented approaches that have dominated software development for over two decades. Although there is anecdotal evidence to suggest that systems analysts experienced in process-oriented modeling approaches will find it difficult to apply objective-oriented methodologies, there is no empirical work investigating the relationship between a procedural mindset and an ability to learn and apply object-oriented concepts. Prior research in human problem solving, however, suggests that the efficacy of a systems analysis and design methodology should be judged in the context of the task to which it is applied. To explore the effects of prior experience and task characteristics on performance in systems analysis and design, we conducted an experiment in which two groups of subjects applied the object-oriented methodology to two types of tasks, one process-oriented and the other object-oriented. One group had significant prior experience in process-oriented methodologies, while the other group had no formal experience. Both groups were provided identical training in object-oriented analysis and design prior to the experiment. The results of the study suggest that both prior experience and task characteristics play a role in determining performance. The implications that follow for research and practice are discussed.     

Nanoscaffold matrices for size-controlled, pulsatile transdermal testosterone delivery: nanosize effects on the time dimension

Pulsatile transdermal testosterone (T) has applications in hormone supplementation and male contraception. Pulsatile T delivery was achieved by assembling crystalline and nanoparticulate T in nucleation-inhibiting polymer matrices of controlled porosity. Different interference patterns observed from various polymeric films containing T were due to the various particle sizes of T present in the polymer matrices. Scanning electron microscopy was used to determine the size and shape of T crystals. Skin-adherent films containing T nanoparticles of any size between 10-500?nm could be prepared using pharmaceutically acceptable vinylic polymers. Drug release and skin permeation profiles were studied. The dissolution-diffusion behavior of nanoparticles differed from crystalline and molecular states. Nanosize may thus be used to engineer chronopharmacologically relevant drug delivery.     

In vitro release dynamics of model drugs from psyllium and acrylic acid based hydrogels for the use in colon specific drug delivery

Psyllium is medicinally important gel forming polysaccharides. Keeping in view, the pharmacological importance of psyllium and drug delivery devices based on hydrogels, psyllium, if suitably tailored to prepare the hydrogels, can act as the double potential candidates for the novel drug delivery systems. Therefore, it is an attempt to prepared psyllium and acrylic acid based pH sensitive novel hydrogels by using N,N'-methylenebisacrylamide (N,N-MBAAm) as crosslinker and ammonium persulfate (APS) as initiator for the use in colon specific drug delivery. The present paper discusses the swelling kinetics of the hydrogels and release dynamics of model drugs (tetracycline hydrochloride, insulin and tyrosine) from drug-loaded hydrogels, for the evaluation of the swelling mechanism and drug release mechanism from the polymeric networks .The effect of pH on the swelling kinetics and release pattern of drugs have been studied by varying the pH of the release medium. It has been observed that swelling and release of drugs from the hydrogels occurred through non-Fickian or anomalous diffusion mechanism in distilled water and pH 7.4 buffer. It shows that the rate of polymer chain relaxation and the rate of drug diffusion from these hydrogels are comparable.     

Biogenic gold nanoparticles as fotillas to fire berberine hydrochloride using folic acid as molecular road map

Use of biologically modified gold nanoparticles (GNPs) as molecular vehicle to ferry potential anti-cancer drug berberine hydrochloride (BHC) using folic acid (FA) as targeting molecule is reported in this work. A tropical fruit peel, Trapa bispinosa is used to fabricate highly monodispersed GNPs, passivated with essential functional groups which were used as linkers to attach FA and BHC via amide linkage. Flocculation Parameter (FP) of biologically synthesized GNPs was calculated under different salt concentrations which were found to be very ideal under a physiological condition. Various statistical models were used to find drug release profile out of which Higuchi was found to be the most ideal. GNP–FA–BHC complexes were found to be active against folic acid expressing HeLa cells.     

Thinning analysis for hot forming of single-piece hemispherical dish end using finite element simulation and its empirical modeling

Hot forming is an important forming method for production of small and medium sized single-piece pressure vessel dish ends. Thinning of the blank material with increased degree of forming is quite obvious. Present work shows finite element (FE) analysis of hot forming of single-piece hemispherical dish end (SPHDE) for predicting maximum thinning of blank during forming. Thinning analysis is performed for SPHDE of two different ferrous material grades SA-387 Gr22 and SA-516 as per ASME, Section II, Part A (2004). Percentage thinning results of FE analysis are verified with the practical material thinning data. Based on the thinning analysis, empirical relation for calculation of percentage thinning as a function of different dish ends′ geometry parameters is proposed. Empirically predicted percentage thinning is observed to be in good agreement with practical and FE simulation results. Thinning results obtained based on proposed FE simulation and empirical model can be helpful to design engineer in selecting thickness of developed blank considering thinning allowance for hot forming of SPHDE. Thinning analysis data can be used for optimizing the dish end geometrical parameters for minimum thinning during forming.     

Influence of calcitonin administration on ultimobranchial and parathyroid glands of pigeon,Columba livia

Pigeons were divided into two numerically equal groups (A and B) containing 30 specimens each. Birds from group A were intraperitoneally injected daily with 0.1 mL/100 g body wt of vehicle (0.1 M acetate buffer, pH 4.3 containing 0.1% gelatin). Specimens from group B were intraperitoneally injected daily with 1 μg/100 g body wt of salmon calcitonin. Six birds were sacrificed from each group 2 h after the last injection on 1st, 3rd, 5th, 10th, and 15th day of the experiment. After collection of blood samples, ultimobranchial and parathyroid glands were fixed for histological studies. In calcitonin-treated C. livia, the plasma calcium levels exhibit a progressive decline from day 1 till day 5. On day 15, the levels become more or less similar to the control value. No change has been noticed on day 1 in the plasma phosphate levels of calcitonin-treated C. livia. The levels decrease progressively from day 3 to day 5; thereafter, it exhibits an elevation so that on day 15, normal plasma phosphate levels is achieved. The ultimobranchial gland of C. livia exhibits no change up to day 5 following calcitonin treatment. The nuclear volume of ultimobranchial cells exhibits a decrease on day 10. This response progresses up to day 15. Few degenerating cells are also discerned following 15 days calcitonin treatment. The parathyroid gland of calcitonin-treated C. livia exhibits no histological alteration up to day 3. The nuclear volume of parathyroidal cells exhibits a progressive increase from day 3 till the close of the experiment (day 15). Moreover, the gland exhibits more compactness on day 10 and day 15. Few degenerating cells are encountered after day 15 following calcitonin treatment. Microsc. Res. Tech. 2009. © 2008 Wiley-Liss, Inc.